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Endocytosis by Trypanosoma Brucei: Proteases and Their Possible Role in the Degradation of Anti-VSG Antibodies

  • J. D. Lonsdale-Eccles
  • D. J. Grab
  • D. C. W. Russo
  • P. Webster
Part of the NATO ASI Series book series (volume 74)

Abstract

African trypanosomes can evade the immune system of their host by changing their variable surface glycoproteins (VSGs). Although healthy parasites do not normally release VSG (Black et al. 1982; Lonsdale-Eccles & Grab, 1986), they can remove surface-bound, VSG-specific antibodies (Seyfang, 1990). We have, therefore, looked for alternative explanations for the disappearance of antibody-VSG complexes such as their possible uptake into the endocytic network of the parasites (Webster, 1989).

Keywords

Cysteine Protease Trypanosoma Brucei Anti Pain Bloodstream Form Variable Surface Glycoprotein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

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Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • J. D. Lonsdale-Eccles
    • 1
  • D. J. Grab
    • 1
  • D. C. W. Russo
    • 1
  • P. Webster
    • 1
  1. 1.ILRADNairobiKenya

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