Endosomes and Cell Signalling

  • Barry I. Posner
  • John J. M. Bergeron
Conference paper
Part of the NATO ASI Series book series (volume 74)

Abstract

The biological responses to many peptide hormones and growth factors are currently under intense investigation. The main area of uncertainty encompasses the transducing events which link initial events at the cell surface to those processes influencing the proteins (egs. enzymes, transporters) effecting the biological response. We have pursued the study of insulin and EGF action by examining the events following ligand-receptor complex formation at the cell surface. Along with others we have observed that these complexes undergo rapid internalization (Posner et al.,1982; Bergeron et al., 1985). In the case of the EGF and insulin receptor this process is accompanied by activation of their respective receptor tyrosine kinases (Cohen et al., 1985; Kay et al., 1986; Khan et al., 1986; Posner et al., 1987).

Keywords

Tyrosine Electrophoresis Sorting Rosen Transferrin 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • Barry I. Posner
    • 1
  • John J. M. Bergeron
    • 2
  1. 1.Depts of MedicineMcGill University and the Royal Victoria HospitalWest MontrealCanada
  2. 2.Depts of AnatomyMcGill University and the Royal Victoria HospitalWest MontrealCanada

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