Regulation of Early Endosome Fusion In Vitro

  • Olivia Steele-Mortimer
  • Michael J. Clague
  • Leo Thomas
  • Jean-Pierre Gorvel
  • Jean Gruenberg
Conference paper
Part of the NATO ASI Series book series (volume 74)


It is well known that molecules entering the cell do so via the early endosome. Within five minutes of internalization into animal cells, lipids, solutes and trans-membrane proteins (including receptors and their bound ligands), appear in early endosomes located predominately at the cell periphery (Griffiths and Gruenberg, 1991; Murphy, 1991). Molecules which return to the plasma membrane, in particular cell surface receptors, are rapidly recycled from the early endosome. In contrast, molecules destined for degradation are transported to the perinuclear late endosomes, and eventually to the lysosomes. The endocytic pathway is also connected, via vesicular traffic, to the biosynthetic pathway (Kornfeld and Mellman, 1989).


Membrane Transport Early Endosome Late Endosome Endocytic Pathway Transport Vesicle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • Olivia Steele-Mortimer
    • 1
  • Michael J. Clague
    • 1
  • Leo Thomas
    • 1
  • Jean-Pierre Gorvel
    • 1
  • Jean Gruenberg
    • 1
  1. 1.European Molecular Biology LaboratoryHeidelbergGermany

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