Intracellular Transport and Post-Translational Modifications of a Secretory Heat Shock Protein of Saccharomyces Cerevisiae
Several heat shock proteins serve as molecular chaperons, assisting in protein maturation by reducing malfoding, mostly in the cytoplasm, nucleus or mitochondria. Some of them, like the BiP protein, which belongs to the 70 kD heat shock proteins, are resident ER-proteins. We have cloned and characterized the first gene, the HSP150 gene of S. cerevisiae which codes for a heat shock protein which is secreted to the exterior of the cell. The function of the protein is as yet unknown, however, it is conserved in divergent yeasts (Russo et al., 1992).
KeywordsHeat Shock Protein HSP150 Gene Hsp150 Protein Heat Shock Gene Protein Maturation
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