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Intracellular Transport and Post-Translational Modifications of a Secretory Heat Shock Protein of Saccharomyces Cerevisiae

  • M. Simonen
  • M. Wikström
  • B. Walse
  • M. Makarow
Conference paper
Part of the NATO ASI Series book series (volume 74)

Abstract

Several heat shock proteins serve as molecular chaperons, assisting in protein maturation by reducing malfoding, mostly in the cytoplasm, nucleus or mitochondria. Some of them, like the BiP protein, which belongs to the 70 kD heat shock proteins, are resident ER-proteins. We have cloned and characterized the first gene, the HSP150 gene of S. cerevisiae which codes for a heat shock protein which is secreted to the exterior of the cell. The function of the protein is as yet unknown, however, it is conserved in divergent yeasts (Russo et al., 1992).

Keywords

Heat Shock Protein HSP150 Gene Hsp150 Protein Heat Shock Gene Protein Maturation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Russo P, Kalkkinen N, Sareneva H, Paakkola J and Makarow M (1992) A heat shock gene from Saccharomyces cerevisiae encoding a secretory glycoprotein. Proc. Natl. Acad. Sci USA 89, 3671–3675.Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • M. Simonen
    • 1
  • M. Wikström
    • 1
    • 2
  • B. Walse
    • 1
    • 2
  • M. Makarow
    • 1
  1. 1.Institute of BiotechnologyUniversity of HelsinkiHelsinkiFinland
  2. 2.Department of Physical ChemistryUniversity of LundSweden

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