Selective Association with Golgi of ADP-Ribosylation Factors, 20-kDa Guanine Nucleotide-Binding Protein Activators of Cholera Toxin
ADP-ribosylation factors are 20-kDa GTP-binding proteins initially identified as factors required for cholera toxin-catalyzed ADP-ribosylation of G9, the stimulatory GTP-binding protein of the adenylyl cyclase system (Kahn and Gilman, 1984; Bobak et al., 1990). The GTP-dependent ARFs enhance activity of the toxin with all of its substrates, and are believed physiologically to participate in protein transport by Golgi (Tsai et al., 1988; Donaldson et al., 1991).
KeywordsCholera Toxin Bovine Brain Selective Association Organelle Fraction Adenylyl Cyclase System
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