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Selective Association with Golgi of ADP-Ribosylation Factors, 20-kDa Guanine Nucleotide-Binding Protein Activators of Cholera Toxin

  • S.-C. Tsai
  • R. Adamik
  • R. Haun
  • J. Moss
  • M. Vaughan
Conference paper
Part of the NATO ASI Series book series (volume 74)

Abstract

ADP-ribosylation factors are 20-kDa GTP-binding proteins initially identified as factors required for cholera toxin-catalyzed ADP-ribosylation of G9, the stimulatory GTP-binding protein of the adenylyl cyclase system (Kahn and Gilman, 1984; Bobak et al., 1990). The GTP-dependent ARFs enhance activity of the toxin with all of its substrates, and are believed physiologically to participate in protein transport by Golgi (Tsai et al., 1988; Donaldson et al., 1991).

Keywords

Cholera Toxin Bovine Brain Selective Association Organelle Fraction Adenylyl Cyclase System 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Bobak DA, Tsai S-C, Moss J, Vaughan M (1990) Enhancement of cholera toxin ADPribosyltransferase activity by guanine nucleotide-dependent ADP-ribosylation factors. In: Moss J, Vaughan M (eds) ADP-ribosylating toxins and G proteins: Insights into signal transduction. American Society for Microbiology, Washington, DC, pp 439–456Google Scholar
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  6. Price SR, Welsh CF, Haun RS, Stanley SJ, Moss J, Vaughan M (1992) Effects of phospholipid and GTP on recombinant ADP-ribosylation factors (ARFs). Molecular basis for differences in requirements for activity of mammalian ARFs. J Biol Chem, in pressGoogle Scholar
  7. Tsai S-C, Noda M, Adamik R, Chang P, Chen H-C, Moss J, Vaughan M (1988) Stimulation of choleragen enzymatic activities by GTP and two soluble proteins purified from bovine brain. J Biol Chem 263: 1768–1772PubMedGoogle Scholar
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Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • S.-C. Tsai
    • 1
  • R. Adamik
    • 1
  • R. Haun
    • 1
  • J. Moss
    • 1
  • M. Vaughan
    • 1
  1. 1.Laboratory of Cellular Metabolism, National Heart, Lung, and Blood InstituteNational Institutes of HealthBethesdaUSA

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