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G Protein Regulation of Vesicular Transport Through the Exocytic Pathway

  • W. E. Balch
  • H. Plutner
  • R. Schwaninger
  • E. J. Tisdale
  • H. W. Davidson
  • J. Bourne
  • S. Pind
  • F. Peter
Conference paper
Part of the NATO ASI Series book series (volume 74)

Abstract

A central problem in cell biology is to understand the molecular basis for the transport of itinerant soluble and membrane-associated macromolecules through multiple compartments of the exocytic and endocytic pathways of eukaryotic cells. Transport involves a multiplicity of components which facilitate the formation of coat protein complexes leading to vesicle budding, and protein complexes involved in vesicle targeting and fusion to downstream compartments. Many gene products involved have been identified through genetic studies in yeast (reviewed in Hicke and Schekman, 1990) and through biochemical approaches (reviewed in Balch, 1990b; Mellman and Simon, 1992; Rothman, 1992), although an understanding of the enyzmological mechanisms involved are largely unknown.

Keywords

Vesicular Transport Endocytic Pathway Vesicular Trafficking Vesicular Stomatitis Virus Glycoprotein Golgi Transport 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • W. E. Balch
    • 1
  • H. Plutner
    • 1
  • R. Schwaninger
    • 1
  • E. J. Tisdale
    • 1
  • H. W. Davidson
    • 1
  • J. Bourne
    • 1
  • S. Pind
    • 1
  • F. Peter
    • 1
  1. 1.Departments of Cell and Molecular BiologyThe Scripps Research InstituteLa JollaUSA

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