Abstract
Platelet-activating factor (PAF), an ether phospholipid, is recognized as being an effective and potent modulator of secretory processes in various cell types (Snyder, 1982). Physio-pathological studies have shown that PAF participates in inflammatory processes and in immune functions (Braquet et al., Res. Pharmacol. Rev., 1987). In the central nervous system, PAF has been isolated from bovine cerebral tissues (Tokumura and Tsukatani, 1986) and Francescangeli and Goracci (1989) demonstrated that rat brain synthesizes PAF under resting conditions. Moreover, Kumar et al. (1988) reported that the rat cerebrum produces PAF in response to convulsive stimuli.
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References
Braquet P, Touqui L, Shen TY, Vargaftig BB (1987) Perspectives in platelet-activating factor research. Pharmacol Rev 39:97–145
Fafeur V, Gouin E, Dray F (1985) Growth hormone releasing factor (GRF) stimulates PGE2 production in rat anterior pituitary. Evidence of a PGE2 involvement in GRF-induced GH release. Biochem Biophys Res Commun 126:725
Francescangeli E and Goracci G (1989) The de novo biosynthesis of PAF in rat brain. Biochem Biophys Res Commun 161:107–112
Junier MP, Tiberghien C., Rougeot C., Fafeur V, Dray F (1988) Inhibitory effect of PAF on LHRH and SRIF release from rat median eminence in vitro correlated with the characterization of specific PAF receptor sites in rat hypothalamus. Endocrinology 123:72–80
Kumar R, Harvey, SA, Kester M, Hanahan DJ and Olson MS (1988) Production and effects of platelet-activating factor in the rat brain. Biochim Biophys Acta 963:375–383
Louis JC, Rougeot C., Bepoldin O, Vulliez B, Mandel P, Dray F (1983) Presence of somatostatin, enkephalins and substance P-like peptides in cultured neurons from embryonic chick cerebral hemispheres. J Neurochem 41:930
Negro-Vilar A, Ojeda SR, McCann SH (1979) Catechol aminergic modulation of LHRH release by median eminence terminals in vitro. Endocrinology 104:1749
Porter JC (1975) Methods for studying pituitary-hypothalamic axis in situ. Methods in Enzymology. Academic Press New York 39:166–183.
Rougeot C., Guillaume V, Junier MP, Fafeur V, Oliver C and Dray F (1986) Prostaglandin E2 does not stimulate GRF release in vivo and in vitro studies. Program of the 6th International Conference on Prostaglandins and Related Compounds, Florence, Italy, p 115 (Abstract)
Rougeot C., Junier M-P, Everaere S, Braquet P, Dray F (1988) PAF-acether stimulates CRF and β-endorphin release. In: Braquet P (ed) The Role of Platelet-Activating Factor in Immune Disorders. New Trends Lipid Mediators Res. vol 2. Karger, Basel, pp 79–84
Rougeot C., Junier MP, Minary P, Weidenfeld J, Braquet P, Dray F (1990) Intracerebroventricular injection of PAF induces secretion of ACTH, β-endorphin and corticosterone in conscious rats. A possible link between the immune and nervous systems. Neuroendocrinology 51:267–275
Rougeot C., Trivers GE, Harris CC, Dray F (1983) ACTH immunoassays: Development of ultrasensitive and specific procedures for the measurement in biological materials. In: Avrameas S, Druet P, Masseyeff R, Feldmann G (eds), Immunoenzymatic Techniques, Developments in Immunology, Vol. 18, Elsevier, Amsterdam, pp 179–191
Snyder F (1982) Platelet-activating factor (PAF), a novel type of phospholipid with diverse biological properties. In: Cordes E. (ed), Annual Reports in Medicinal Chemistry, vol 17, p 243
Tokumura A, Tsukatani M (1986) Determination of molecular species of platelet-activating factor in bovine brain lipid extract. Program 2nd Int. Conf. on PAF, Gatlinburg, p 37
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© 1993 Springer-Verlag Berlin Heidelberg
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Dray, F., Rougeot, C., Tiberghien, C., Junier, MP. (1993). PAF and Hypothalamic Secretions in the Rat. In: Massarelli, R., Horrocks, L.A., Kanfer, J.N., Löffelholz, K. (eds) Phospholipids and Signal Transmission. Nato ASI Series, vol 70. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-02922-0_30
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DOI: https://doi.org/10.1007/978-3-662-02922-0_30
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