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CDPcholine, CDPethanolamine, Lipid Metabolism and Disorders of the Central Nervous System

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Phospholipids and Signal Transmission

Part of the book series: Nato ASI Series ((volume 70))

Abstract

CDPamines are essential precursors for the biosynthesis de novo of phosphatidylcholine and phosphatidylethanolamine. The phosphoamine moiety is enzymically transferred to the diacylglycerol or other diradylglycerol by the choline or ethanolami ne specific phosphotransferase. As described in the following sections, CDPamines, especially CDPcholine, have been used to reverse increases in fatty acid levels following ischemia. CDPcholine has been used successfully to treat several types of central nervous system diseases including ischemia, Parkinson disease, cerebrovascular disease, senile dementia, and tardive dyskinesia. CDPcholine effects in these diseases may be related in part to its ability to increase dopamine levels.

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Authors and Affiliations

  1. Dept. of Medical Biochemistry and Neuroscience Program, The Ohio State University, Columbus, Ohio, 43210, USA

    Eric J. Murphy & Lloyd A. Horrocks

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  1. Eric J. Murphy
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  2. Lloyd A. Horrocks
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Editors and Affiliations

  1. CNRS, Centre de Neurochimie, Strasbourg, France

    Raphaël Massarelli (Director of Research) (Director of Research)

  2. Department of Medical Biochemistry, College of Medicine, The Ohio State University, Columbus, Ohio, USA

    Lloyd A. Horrocks (Professor Emeritus) (Professor Emeritus)

  3. Department of Biochemistry and Molecular Biology, The University of Manitoba, Winnipeg, Manitoba, Canada

    Julian N. Kanfer (Professor) (Professor)

  4. Department of Pharmacology, University of Mainz, Mainz, Germany

    Konrad Löffelholz (Professor) (Professor)

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© 1993 Springer-Verlag Berlin Heidelberg

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Murphy, E.J., Horrocks, L.A. (1993). CDPcholine, CDPethanolamine, Lipid Metabolism and Disorders of the Central Nervous System. In: Massarelli, R., Horrocks, L.A., Kanfer, J.N., Löffelholz, K. (eds) Phospholipids and Signal Transmission. Nato ASI Series, vol 70. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-02922-0_28

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  • DOI: https://doi.org/10.1007/978-3-662-02922-0_28

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-02924-4

  • Online ISBN: 978-3-662-02922-0

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