Tacrine (Tetrahydroaminoacridine) and the Metabolism of Acetylcholine and Choline

  • Stanislav Tuček
  • Vladimír Doležal
Conference paper
Part of the Nato ASI Series book series (NATO ASI, volume 70)


Tacrine (9-amino-1,2,3,4-tetrahydroacridine) is a reversible noncompetitive inhibitor of cholinesterases (Shaw and Bentley, 1953; Heilbronn, 1961; Patocka et al., 1976; Bajgar et al., 1979; Marquis, 1990) which has been described to have a marked positive effect in the treatment of patients with Alzheimer’s disease (Summers et al., 1986). Since the attempts to treat such patients with other potent inhibitors of cholinesterases had been less successful or not successful at all, the possibility appears likely that tacrine acts not only by inhibiting cholinesterases, but also by producing some additional pharmacological effects.


Choline Oxidase Choline Ester Choline Acetyl False Transmitter Sodium Tetraphenylboron 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • Stanislav Tuček
    • 1
  • Vladimír Doležal
    • 1
  1. 1.Institute of PhysiologyCzechoslovak Academy of SciencesPragueCzechoslovakia

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