Tacrine (Tetrahydroaminoacridine) and the Metabolism of Acetylcholine and Choline
Tacrine (9-amino-1,2,3,4-tetrahydroacridine) is a reversible noncompetitive inhibitor of cholinesterases (Shaw and Bentley, 1953; Heilbronn, 1961; Patocka et al., 1976; Bajgar et al., 1979; Marquis, 1990) which has been described to have a marked positive effect in the treatment of patients with Alzheimer’s disease (Summers et al., 1986). Since the attempts to treat such patients with other potent inhibitors of cholinesterases had been less successful or not successful at all, the possibility appears likely that tacrine acts not only by inhibiting cholinesterases, but also by producing some additional pharmacological effects.
KeywordsCholine Oxidase Choline Ester Choline Acetyl False Transmitter Sodium Tetraphenylboron
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- Gardiner IM, de Belleroche J (1990) Modulation of gamma-aminobutyric acid release in cerebral cortex by fluoride, phorbol ester, and phosphodiesterase inhibitors: differential sensitivity of acetylcholine release to fluoride and K+ channel blockers. J Neurochem 54:1130–1135PubMedCrossRefGoogle Scholar