Abstract
Considerable effort has been expended to unravel the details of the mechanisms that allow a cell to respond in a predetermined manner to the arrival of a ligand at the external surface of its plasma membrane. Although it is well accepted that the proteins residing in these membranes function as receptors or channels, it is reasonable to assume that the lipids present in this lipid enriched environment also play a role in these mechanisms. This is illustrated by the polyphosphoinositides which are cleaved by a specific phospholipase C and are the source of the phosphorylated inositols responsible for the release of calcium from intracellular stores (Hokin, 1985). A decade ago it was fashionable to investigate the involvement of the phospholipid N-methyl transferases that were proposed to be important for signal transmission across biological membranes (Hirata and Axelrod, 1980).
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© 1993 Springer-Verlag Berlin Heidelberg
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Singh, I., McCartney, D., Massarelli, R., Kanfer, J.N. (1993). Phospholipid Metabolism in a Human Cholinergic Cell Line — Possible Involvement of the Base Exchange Enzyme Activities. In: Massarelli, R., Horrocks, L.A., Kanfer, J.N., Löffelholz, K. (eds) Phospholipids and Signal Transmission. Nato ASI Series, vol 70. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-02922-0_24
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DOI: https://doi.org/10.1007/978-3-662-02922-0_24
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