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Lipid Synthesis and Targeting to the Mammalian Cell Surface

  • Conference paper
Phospholipids and Signal Transmission

Part of the book series: Nato ASI Series ((volume 70))

Abstract

Eukaryotic cells are surrounded by a plasma membrane that delimits their cytoplasm, which itself is filled with numerous intracellular membranes sometimes enclosing yet other membranous systems. It is well-organized that the various organelles subsume different functions and possess unique protein and lipid composition. A fundamental questions is how the dynamic interplay between local synthesis, modification and degradation on the one hand, and the various modes of lipid traffic with their inherent sorting potential on the other hand, result in the stable intracellular lipid heterogeneity so similar among the different cell types. This review summarizes our knowledge on lipid traffic, addresses the localization of the sorting events, and provides some working hypotheses on the mechanisms of lipid sorting with primary emphasis on the appearance of lipids at the cell surface. Cellular lipid traffic will undoubtedly be more complicated than the schemes provided here. However, the complications may turn out to be variations on a common theme.

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  1. Alex Sandra

    Present address: Dept. of Anatomy, College of Medicine, University of Iowa, Iowa City, IA, 52242, USA

Authors and Affiliations

  1. Department of Cell Biology, AZU H02.314, Medical School, University of Utrecht, Heidelberglaan 100, 3584, CX, Utrecht, USA

    Alex Sandra, Wouter van’t Hof, Ida van Genderen & Gerrit van Meer

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  1. Alex Sandra
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  2. Wouter van’t Hof
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Editors and Affiliations

  1. CNRS, Centre de Neurochimie, Strasbourg, France

    Raphaël Massarelli (Director of Research) (Director of Research)

  2. Department of Medical Biochemistry, College of Medicine, The Ohio State University, Columbus, Ohio, USA

    Lloyd A. Horrocks (Professor Emeritus) (Professor Emeritus)

  3. Department of Biochemistry and Molecular Biology, The University of Manitoba, Winnipeg, Manitoba, Canada

    Julian N. Kanfer (Professor) (Professor)

  4. Department of Pharmacology, University of Mainz, Mainz, Germany

    Konrad Löffelholz (Professor) (Professor)

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Sandra, A., van’t Hof, W., van Genderen, I., van Meer, G. (1993). Lipid Synthesis and Targeting to the Mammalian Cell Surface. In: Massarelli, R., Horrocks, L.A., Kanfer, J.N., Löffelholz, K. (eds) Phospholipids and Signal Transmission. Nato ASI Series, vol 70. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-02922-0_2

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