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Resisting Memory Storage: Activating Endogenous Protein Kinease C Inhibitors

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Phospholipids and Signal Transmission

Part of the book series: Nato ASI Series ((volume 70))

Abstract

We have recently proposed a model of long-term potentiation (LTP), a physiological model of memory storage in the brain, that has as its major theme the view that signal transduction mechanisms on both sides of the synapse leads to the enhanced synaptic communication of LTP (Colley and Routtenberg, 1992). This involves a sequence of events requiring bidirectional communication, the first signal being presynaptic transmitter release. A modified version of this model is shown in Figure 1. In the present chapter I will first review the model and then discuss the likely control points in the sequence and the synergistic relation between messengers and retrograde signals.

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Author information

Authors and Affiliations

  1. Cresap Neuroscience Laboratory, Northwestern University, 2021 Sheridan Road, Evanston, Illinois, 60208, USA

    Aryeh Routtenberg

Authors
  1. Aryeh Routtenberg
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Editor information

Editors and Affiliations

  1. CNRS, Centre de Neurochimie, Strasbourg, France

    Raphaël Massarelli (Director of Research) (Director of Research)

  2. Department of Medical Biochemistry, College of Medicine, The Ohio State University, Columbus, Ohio, USA

    Lloyd A. Horrocks (Professor Emeritus) (Professor Emeritus)

  3. Department of Biochemistry and Molecular Biology, The University of Manitoba, Winnipeg, Manitoba, Canada

    Julian N. Kanfer (Professor) (Professor)

  4. Department of Pharmacology, University of Mainz, Mainz, Germany

    Konrad Löffelholz (Professor) (Professor)

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© 1993 Springer-Verlag Berlin Heidelberg

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Routtenberg, A. (1993). Resisting Memory Storage: Activating Endogenous Protein Kinease C Inhibitors. In: Massarelli, R., Horrocks, L.A., Kanfer, J.N., Löffelholz, K. (eds) Phospholipids and Signal Transmission. Nato ASI Series, vol 70. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-02922-0_13

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  • DOI: https://doi.org/10.1007/978-3-662-02922-0_13

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-02924-4

  • Online ISBN: 978-3-662-02922-0

  • eBook Packages: Springer Book Archive

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