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Y Chromosome Function in Spermatogenesis

  • Conference paper
Spermatogenesis — Fertilization — Contraception

Part of the book series: Schering Foundation Workshop ((SCHERING FOUND,volume 4))

Abstract

In mammals a function of the Y chromosome during spermatogenesis has long been hidden by the sex determining function of the Y chromosome in this species class. In contrast to Drosophila, where a X,O-karyotype is compatible with a normal viable male, although sterile, in humans the same karyotype is related to a female with sterility and different phenotype abnormalities commonly known as Turner’s syndrome (Turner 1938). This state of affairs persisted until 1976, when Tiepolo and Zuffardi (1976) presented clear evidence that the human Y chromosome also must have a function in spermatogenesis. Analyzing a terminal deletion in the Y chromosome of six sterile males with a normal phenotype but azoospermia, they suggested a male fertility gene complex called azoospermia factor (AZF), and located to the distal region of the euchromatic part of the long Y arm (Yg11).

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References

  • Alvesalo L, de la Chapelle A (1981) Tooth size in two males with deletions of the long arm of the Y chromosome. Ann Hum Genet 54: 49–54

    Google Scholar 

  • Andersson M, Page DC, Brown LG, Elfving K, de la Chapelle A (1988a) Characterization of a (Y;4) translocation by DNA hybridization. Hum Genet 78: 377–381

    PubMed  CAS  Google Scholar 

  • Andersson M, Page DC, Pettay D, Subrt I, Turleau C, Grouchy J, de la Chapelle A (1988b) Y;autosome translocations and mosaicism in the aetiology of 45,X maleness: assignment of fertility factor to distal Yq l 1. Hum Genet 79: 2–7

    PubMed  CAS  Google Scholar 

  • Arnemann J, Jakubiczka S, Thüring S, Schmidtke J (1991) Cloning and sequence analysis of human Y chromosome-derived, testicular cDNA, TSPY. Genomics 11: 108–114

    Google Scholar 

  • Ballabio A, Carrozzo R, Gil A, Gillard B, Affara N, Ferguson-Smith MA, Fraser N, Craig I, Rocchi M, Romeo G, Andria G (1989) Molecular characterization of human X/Y translocations suggests their aetiology through aberrant exchange between homologous sequences on Xp and Xq. Ann Hum Genet 53: 9–14

    PubMed  CAS  Google Scholar 

  • Bandmann HJ, Breit R (1984) Klinefelter’s syndrome. Springer Verlag, Heidelberg

    Google Scholar 

  • Bardoni B, Zuffardi O, Guioli S, Ballabio A, Simi P, Cavalli P, Grimoldi G, Fraccaro M, Camerino G (1991) A deletion map of the human Ygil region: Implications for the evolution of the Y chromosome and tentative mapping of a locus involved in spermatogenesis. Genomics 11: 443–451

    Google Scholar 

  • Bernstein R (1985) X;Y chromosome translocations and their manifestations. In: Sandberg AA (ed) The Y chromosome, Part B: Clinical aspects of Y chromosome abnormalities (Alan R. Liss, Inc., New York ) p 171–206

    Google Scholar 

  • Beverstock GC, Macfarlane JD, Veenema H, Hoekman H, Goodfellow PJ (1989) Y chromosome specific probes identify breakpoint in a 45,X/46,X,del(Y)(pter-811.1:) karyotype of an infertile male. J Med Genet 26: 330–342

    PubMed  CAS  Google Scholar 

  • Billingham RE, Hings IM (1981) The H-Y antigen and its role in natural transplantation. Hum Genet 58: 9–17

    PubMed  CAS  Google Scholar 

  • Bishop CE, Hatat D (1987) Molecular cloning and sequence analysis of a mouse Y chromosome RNA transcript expressed in the testis. Nucleic Acids Res 15: 2959–2969

    PubMed  CAS  Google Scholar 

  • Bishop C, Guellaen G, Geldwerth D, Fellous M, Weissenbach J (1984) Extensive sequence homologies between the Y and other human chromosomes. J Mol Biol 173: 403–417

    PubMed  CAS  Google Scholar 

  • Bobrow M, Pearson PL, Pike MC, El-Alfi OS (1971) Length variation in the quinacrine-binding segment of human Y chromosomes of different sizes. Cytogenetics 10: 190–198

    PubMed  CAS  Google Scholar 

  • Bourgoyne P (1982) Genetic homology and crossing over in the X and Y chromosomes of mammals. Hum Genet 61: 85–90

    Google Scholar 

  • Bourgoyne P (1991) Y chromosome function in mammalian development. Adv in Developmental Biology vol 1: 1–29

    Google Scholar 

  • Brown SW (1966) Heterochromatin, Science 151: 418–425

    Google Scholar 

  • Bühler EM, Müller H, Müller J, Stalder GR (1971) Variant of the fluorescence pattern in an abnormal human Y chromosome. Nature 234: 348

    PubMed  Google Scholar 

  • Cantrell MA, Simpson E, Bicknell JN, Pagon RA, Walker DC, Thuline HC, Graham JM, Disteche CM (1989) Absence of H-Y antigen expression in a patient with deletion of the long arm of the Y chromosome and isolation of new DNA probes for region 6 of the Y chromosome. Am J Hum Genet 45: A134

    Google Scholar 

  • Caspersson T, Zech L, Johansson J, Lindsten J, Therkelsen A, Zech L (1971) Translocations causing non-fluorescent Y chromosomes in human XO/XY mosaics. Hereditas 68: 281–304

    Google Scholar 

  • Chandley A (1989) Asymmetry in chromosome pairing: a major factor in de novo mutation and the production of genetic disease in man. J Med Genet 26: 546–552

    PubMed  CAS  Google Scholar 

  • Chandley AC, Edmond P (1971) Meiotic studies on a subfertile patient with a ring Y chromosome. Cytogenetics 10: 295–304

    PubMed  CAS  Google Scholar 

  • Chandley A, Maclean N, Edmond P, Fletcher J, Watson GS (1976) Cytogenetics and infertility in man. II. Testicular histology and meiosis. Ann Hum Genet 40: 165–176

    Google Scholar 

  • Chandley A, Goetz P, Hargreave TB, Joseph AM, Speed RM (1984) On the nature and extent of XY pairing at meiotic prophase in man. Cytogenet Cell Genet. 38: 241–247

    PubMed  CAS  Google Scholar 

  • Chandley AC, Ambros P, McBeath S, Hargreave TB, Kilanowski F, Spowart G (1986) Short arm dicentric Y chromosome with associated statural defects in a sterile man. Hum Genet 73: 350–353

    PubMed  CAS  Google Scholar 

  • Coyne JA (1985) The genetic basis of Haldane’s rule. Nature 314: 736–738

    PubMed  CAS  Google Scholar 

  • Daiger SP, Wildin RS, Su T-S (1982) Sequences on the human Y chromosome homologous to the autosomal gene for argininosuccinate synthetase. Na-ture 298: 682–684

    CAS  Google Scholar 

  • Daniel A (1985) Y isochromosomes and rings. In: Sandberg AA (ed) The Y chromosome, Part B: Clinical aspects of Y chromosome abnormalities. Alan R. Liss, Inc., New York, pp 105–135

    Google Scholar 

  • de Kretser DM, Burger HG, Hudson B (1974) The relationship between germinal cells and serum FSH levels in males with infertility. Clin Endocrinol Metab 38: 787–793

    CAS  Google Scholar 

  • de la Chapelle A (1981) The etiology of maleness in XX men. Hum Genet 58: 105–116

    PubMed  Google Scholar 

  • de la Chapelle A, Page DC, Brown L, Kaski U, Parvinen T, Tippett A (1986) The origin of 45,X males. Am J Hum Genet 38: 330–340

    PubMed  Google Scholar 

  • Disteche CM, Brown L, Saal H, Friedman C, Thuline HC, Hoar DI, Pagon RA, Page DC (1986a) Molecular detection of a translocation (Y;15) in a 45,X male. Hum Genet 74: 372–377

    PubMed  CAS  Google Scholar 

  • Disteche CM, Casanova M, Saal H, Friedman C, Sybert V, Graham J, Thuline H, Page DC, Fellous M (1986b) Small deletions of the short arm of the Y chromosome in 46,XY females. Proc Natl Acad Sci USA 83: 7841–7844

    PubMed  CAS  Google Scholar 

  • Donlon TA, Müller U (1991) Deletion mapping of DNA segments from the Y chromosome long arm and their analysis in an XX male. Genomics 10: 51–56

    PubMed  CAS  Google Scholar 

  • Evans HJ, Gosden JR, Mitchell AR, Buckland RA (1974) Location of human satellite DNAs on the Y chromosome. Nature 251: 346–347

    CAS  Google Scholar 

  • Ferguson-Smith MA, Affara NA, Magenis RE (1987) Ordering of Y specific sequences by deletion mapping and analysis of X-Y interchange males and females. Development 101 (Supplement): 41–50

    PubMed  Google Scholar 

  • Fernandez-Piqueras J, Ludefia P, De Cabo SF, Velazquez M, Sentis C (1991) Longitudinal differentiation of the human Yq heterochromatin as revealed by the restriction enzyme TaqI. Cytogenet Cell Genet 57: 78–81

    PubMed  CAS  Google Scholar 

  • Fisher EMC, Alitalo T, Luoh S-W, de la Chapelle A, Page DC (1990a) Human sex-chromosome-specific repeats within a region of pseudoautosomal/Yq homology. Genomics 7: 625–628

    PubMed  CAS  Google Scholar 

  • Fisher EMC, Beer-Romero P, Brown LG, Ridley A, McNeil JA, Lawrence JB, Willard HF, Bieber FR, Page DC (1990b) Homologous ribosomal protein genes on the human X and Y chromosomes: Escape from X inactivation and possible implications for Turner syndrome. Cell 63: 1205–1218

    Google Scholar 

  • Fryns JP, Cassiman JJ, Van den Berghe H (1978) Unusual in vivo rearrangments of the Y chromosome with mitotic instability in vitro. Hum Genet 44: 349–355

    PubMed  CAS  Google Scholar 

  • Fryns P, Kleczkowska A, Van den Berghe H (1985) Clinical manifestations of Y/autosome translocations in man. In: Sandberg AA (ed) The Y chromosome, Part B: Clinical aspects of Y chromosome abnormalities Alan R. Liss, Inc., New York pp 213–243

    Google Scholar 

  • Gabriel-Robez O, Rumpler Y, Ratomponirina C, Petit C, Levilliers J, Croquette MF, Couturier J (1990) Deletion of the pseudoautosomal region and lack of sex-chromosome pairing at pachytene in two infertile men carrying an X;Y translocation. Cytogenet Cell Genet 54: 38–42

    PubMed  CAS  Google Scholar 

  • Gal A, Weber B, Neri G, Serra A, Müller U, Schempp W, Page DC (1987) A 45,X male with Y-specific DNA translocated onto chromosome 15. Am J Hum Genet 40: 477–488

    PubMed  CAS  Google Scholar 

  • Giraud F, Mattei JF, Lucas C, Mattai MG (1977) Four new cases of dicentric Y chromosomes. Hum Genet 36: 249–260

    PubMed  CAS  Google Scholar 

  • Gomez-Pedrozo M, Mohandas T, Sparkes R, Shaw J-P, Hess JF, Ayres TM, Shen C-KJ (1987) Evolution of human cytoplasmic actin gene sequences: chromosome mapping and structural characterizations of three cytoplasmic actin-like pseudogenes including one on the Y chromosome. J Hum Evol 16: 215–230

    Google Scholar 

  • Goodfellow PJ, Darling SM, Thomas NS, Goodfellow PN (1986) A pseudoautosomal gene in man. Science 234: 740–742

    PubMed  CAS  Google Scholar 

  • Gough NM, Gearing DP, Nicola NA, Baker E, Pritchard M, Callen DF, Sutherland GR (1990) Localization of the human GM-CSF receptor gene to the X-Y pseudoautosomal region. Nature 345: 734–736

    PubMed  CAS  Google Scholar 

  • Hartung M, Devictor M, Codaccioni JL, Stahl A (1988) Yq deletion and failure of spermatogenesis. Ann Genet 31: 21–26

    PubMed  CAS  Google Scholar 

  • Henke A, Wapenaar M, van Ommen GJ, Maraschio P, Camerino G, Rappold G (1991) Deletions within the pseudoautosomal region help map three new markers and indicate a possible role of this region in linear growth. Am J Hum Genet 49: 811–819

    PubMed  CAS  Google Scholar 

  • Jalal SM, Pfeiffer RA, Pathak S, Hsu TC (1974) Subdivision of the human Y chromosome. Humangenetik 24: 59–65

    PubMed  CAS  Google Scholar 

  • Johnson MD, Tho SPT, Behzadian A, McDonough PG (1989) Molecular scanning of Yg11 (interval 6) in men with Sertoli-cell-only syndrome. Am J Obstet Gynecol 161: 1732–1737

    PubMed  CAS  Google Scholar 

  • Jutley JK, Stewart AD (1985) Genetic analysis of the Y chromosome of the mouse: evidence for two loci affecting androgen metabolism. Genet Res Camb 47: 29–34

    Google Scholar 

  • Kay GF, Ashworth A, Penny GD, Dunlop M, Swift S, Brockdorff N, Rastan S (1991) A candidate spermatogenesis gene on the mouse Y chromosome is homologous to ubiquitin-activating enzyme El. Nature 354: 486–489

    PubMed  CAS  Google Scholar 

  • Kelberman L, Barlow P, Vosa CG (1970) The Y chromosome in human spermatozoa. Nature 226: 961–962

    Google Scholar 

  • Knowlton RG, Nelson CA, Brown VA, Page DC, Donis-Keller H (1989) An extremely polymorphic locus on the short arm of the human X chromosome with homology to the long arm of the Y chromosome. Nucl Acid Res 17: 423–437

    CAS  Google Scholar 

  • Koopman P, Ashworth A, Lovell-Badge R (1991) The ZFY gene family in humans and mice. T I G 7: 132–136

    CAS  Google Scholar 

  • Kosztolanyi G, Trixler M (1983) Yq deletion with short stature, abnormal male development, and schizoid character disorder. J Med Genet 20: 393–394

    PubMed  CAS  Google Scholar 

  • Lau YFC, Chan K (1989) The putative testis-determining factor and related genes are expressed as discrete-sized transcripts in adult gonadal and somatic tissues. Am J Hum Genet 45: 942–952

    PubMed  CAS  Google Scholar 

  • Leroy P, Seboun E, Mattei MG, Fellous M, Bishop CE (1987) Testis-specific transcripts detected by a human Y-DNA-derived probe. Development 101 (Supplement), 177–183

    PubMed  CAS  Google Scholar 

  • Levy ER, Burgoyne PS (1986) The fate of XO germ cells in the testes of XO/XY and XO/XY/XYY mouse mosaics: evidence for a spermatogenesis gene on the mouse Y chromosome. Cytogenet Cell Genet 42: 208–213

    PubMed  CAS  Google Scholar 

  • Limon J, Gibas Z, Kaluzewski B, Moruzgala T (1979) Demonstration of two different regions of lateral asymmetry in human Y chromosomes. Hum Genet 51: 247–252

    PubMed  CAS  Google Scholar 

  • Lucotte G, Ngo NY (1985) p49f, a highly polymorphic probe, that detects TaqI RFLPs on the human Y chromosome. Nucl Acid Res 13: 8285

    Google Scholar 

  • Lukusa T, Fryns JP, van den Berghe H (1986) Gonadoblastoma and Y-chro-mosome fluorescence. Clin Genet 29: 311–316

    PubMed  CAS  Google Scholar 

  • Ma K, Sharkey A, Kirsch S, Vogt P, Hargreave TB, McBeath S, Chandley AC (1992) Towards the molecular localization of the AZF locus: mapping of microdeletions in azoospermic men within 14 subintervals of interval 6 of the human Y chromosome. submitted

    Google Scholar 

  • Magenis E, Donlon T (1982) Nonfluorescent Y chromosomes. Cytological evidence of origin. Hum Genet 60: 133–138

    Google Scholar 

  • Malaspina P, Persichetti F, Novelletto A, lodice C, Terrenato L, Wolfe J, Ferraro M, Prantera G (1990) The human Y chromosome shows a low level of DNA polymorphism. Ann Hum Genet 54: 297–305

    PubMed  CAS  Google Scholar 

  • Mikelsaar A-vN, Tüür SJ Käosaar ME (1973) Human karyotype polymorphism. I. Routine and fluorescence microscopic investigation of chromosomes in a normal adult population. Humangenetik 20: 89–101

    Google Scholar 

  • Mitchell MJ, Woods DR, Tucker PK, Opp JS, Bishop CE (1991) Homology of a candidate spermatogenic gene from the mouse Y chromosome to the ubiquitin-activating enzyme El. Nature 354: 483–486

    PubMed  CAS  Google Scholar 

  • Müller U, Fontaine D, Adinolfi M, Fraccaro M and Lalande M (1989) Analysis of complex Y chromosome aberrations using a single DNA probe (Y367). Cytogenet Cell Genet 50: 161–164

    PubMed  Google Scholar 

  • Müller U, Lalande M (1990) A physical map of the human Y chromosome short arm. Genomics 7: 517–523

    PubMed  Google Scholar 

  • Nagamine CM, Chan K, Kozak CA and Lau Y-F (1989) Chromosome mapping and expression of a putative testis-determing gene in mouse. Science 243: 80–83

    PubMed  CAS  Google Scholar 

  • Nakahori Y, Takenaka O, Nakagome Y (1991) A human X-Y homologous region encodes “amelogenin”. Genomics 9: 264–269

    PubMed  CAS  Google Scholar 

  • Neu RL, Matthew MS, Barlow Jr MD, Gardner LI (1973) A 46,XYq-male with aspermia. Fertil Steril 24: 811–813

    PubMed  CAS  Google Scholar 

  • Ngo KY, Vergnaud G, Johnsson C, Lucotte G, Weissenbach J (1986) A DNA probe detecting multiple haplotypes of the human Y chromosome. Am J Hum Genet 38: 407–418

    PubMed  CAS  Google Scholar 

  • North M, Sargent C, O’Brien J, Taylor K, Wolfe J, Affara NA, Ferguson-Smith MA (1991) Comparison of ZFY and ZFX gene structure and analysis of alternative 3’untranslated regions of ZFY. Nucl Acid Res 19: 2579–2586

    CAS  Google Scholar 

  • Ohno S, Nagai Y, Ciccarese S, Iwata H (1979) Testis-organizing H-Y antigen and the primary sex-determining mechanism of mammals. Recent Prog Horm Res 35: 449–476

    PubMed  CAS  Google Scholar 

  • Oosthuizen CJJ, Herbert JS, Vermaak LK, Brusnicky J, Fricke J, du Plessis L, Retief AE (1990) Deletion mapping of 39 random isolated Y chromosome DNA fragments. Hum Genet 85: 205–210

    PubMed  CAS  Google Scholar 

  • Page DC (1987) Hypothesis: a Y chromosomal gene causes gonadoblastoma in dysgenetic gonads. Development 101 (Supplement): 151–155

    PubMed  Google Scholar 

  • Page DC, Harper ME, Love J, Botstein D (1984) Occurrence of a transposition from the X-chromosome long arm to the Y-chromosome short arm during human evolution. Nature 311: 119–123

    PubMed  CAS  Google Scholar 

  • Page DC, Mosher R, Simpson EM, Fisher EMC, Mardon G, Pollack J, McGillivray B, de la Chapelle A, Brown LG (1987) The sex-determining region of the human Y chromosome encodes a finger protein. Cell 51: 1091–1104

    PubMed  CAS  Google Scholar 

  • Pearson PL, Bobrow M, Vosa CG (1970) Technique for Identifying Y chromosomes in human interphase nuclei. Nature 226: 78–80

    PubMed  CAS  Google Scholar 

  • Pedicini A, Camerino G, Avarello R, Guioli S, Zuffardi O (1991) Probe St35239 (DXYS64) reveals homology between the distal ends of Xq and Yq. Genomics 11: 482–483

    PubMed  CAS  Google Scholar 

  • Pfeiffer RA, Lambertz B, Friederiszick FK, Distel H, Pawlowitzki IH, Nicole R, Ober KG, Ruckes J (1968) Die nosologische Stellung des X0/XY-Mosaizismus. Archiv f Gynäkologie 206: 369–410

    CAS  Google Scholar 

  • Petit C, de la Chapelle A, Levilliers J, Castillo S, Noel B, Weissenbach J (1987) An abnormal terminal X-Y interchange accounts for most but not all cases of human XX maleness. Cell 49: 595–602

    PubMed  CAS  Google Scholar 

  • Pohlschmidt M, Rappold G, Krause M, Ahlert D, Hosenfeld D, Weissenbach J, Gal A (1991) Ring Y chromosome: molecular characterization by DNA probes. Cytogenet Cell Genet 56: 65–68

    PubMed  CAS  Google Scholar 

  • Rappold G and Lehrach H (1988). A long range restriction map of the pseudoautosomal region by partial digest PFGE analysis from the telomere. Nucl Acids Res 16: 5361–5377

    PubMed  CAS  Google Scholar 

  • Reitalu J (1973) A familial Y-22 translocation in man. Hereditas 74: 155–160

    PubMed  CAS  Google Scholar 

  • Rouyer F, Simmler M-C, Johnsson C, Vergnaud G, Cooke HJ, Weissenbach J (1986). A gradient of sex linkage in the pseudoautosomal region of the human sex chromosomes. Nature 319: 291–295

    PubMed  CAS  Google Scholar 

  • Schempp W (1985) High resolution replication of the human Y chromosome. In: Sandberg AA (editor) The Y chromosome Part A: Basic characteristics of the Y chromosome. Alan R. Liss, New York, pp 357–371

    Google Scholar 

  • Schneider-Gädicke A, Beer-Romero P, Brown LG, Mardon G, Luoh S-W, Page DC (1989) Putative transcription activator with alternative isoforms encoded by human ZFX gene. Nature 342: 708–711

    PubMed  Google Scholar 

  • Scully RE (1970) Gonadoblastoma: a review of 74 cases. Cancer 25: 1340–1356

    PubMed  CAS  Google Scholar 

  • Seboun E, Leroy P, Casanova M, Magenis E, Boucekkine C, Disteche C, Bishop C, Fellous M (1986) A molecular approach to the study of the human Y chromosome and anomalies of sex determination in man. Cold Spring Harbor Symp: Molecular biology of homo sapiens. Vol 51: 237–248

    Google Scholar 

  • Simpson E, Chandler P, Goulmy E, Page DC, Disteche C, Ferguson-Smith MA (1987) Separation of the genetic loci for the H-Y antigen and testis determination on human Y chromosome. Nature 326: 876–878

    PubMed  CAS  Google Scholar 

  • Sinclair AH, Berta P, Palmer MS, Hawkins JR, Griffiths BL, Smith MJ, Foster JW, Frischauf A, Lovell-Badge R, Goodfellow PN (1990) A gene from the human sex determining region encodes a protein with homology to a conserved DNA-binding motif. Nature 346: 240–244

    PubMed  CAS  Google Scholar 

  • Smith A, Fraser IS, Elliot G (1979) An infertile male with balanced Y;19 translocation. Review of Y;autosome translocations. Ann Genet 22: 189194

    Google Scholar 

  • Smith KD, Young KE, Talbot CC, Schmeckpeper BJ (1987) Repeated DNA of the human Y chromosome. Development 101 (Suplement): 77–92.

    PubMed  CAS  Google Scholar 

  • Sohval AR (1964) Hermaphroditism with “atypical” or “mixed” gonadal dys-genesis. Amer J Med 36: 281–292

    PubMed  CAS  Google Scholar 

  • Solari AJ (1980) Synaptonemal complexes and associated structures in micro-spread human spermatocytes. Chromosoma 81: 315–337

    PubMed  CAS  Google Scholar 

  • Soudek D, Langmuir V, Stewart DJ (1973) Variation in the nonfluorescent segment of long Y chromosome. Humangenetik 18: 285–290

    PubMed  CAS  Google Scholar 

  • Speed RM, Chandley AC (1990) Prophase of meiosis in human spermatocytes analysed by EM microspreading in infertile men and their controls and comparisons with human oocytes. Hum Genet 84: 547–554

    PubMed  CAS  Google Scholar 

  • Speed RM, Faed MJW, Batstone PJ, Baxby K, Barnetson W (1991) Persistence of two Y chromosomes through meiotic prophase and metaphase I in an XYY man. Hum Genet 87: 416–420

    PubMed  CAS  Google Scholar 

  • Sperling K, Lackmann I (1971) Large human Y chromosome with two fluorescent bands. Clinical Genetics 2: 352–355

    PubMed  CAS  Google Scholar 

  • Spurdle AB, Morris DJ, Jenkins T (1989) Y-chromosome probe p49f detects new TaqI variants and complex PvuII haplotypes. Cytogenet Cell Genet 51: 1084

    Google Scholar 

  • Stahl A, Hartung M, Devictor M, Berge’-Lefranc J-L (1984) The association of the nucleolus and the short arm of acrocentric chromosomes with the XY pair in human spermatocytes: its possible role in facilitating sex-chromosome acrocentric translocations. Hum Genet 68: 173–180

    PubMed  CAS  Google Scholar 

  • Steinbach P, Fabry H, Scholz W (1979) Unstable ring Y chromosome in an aspermic male. Hum Genet 47: 227–231

    PubMed  CAS  Google Scholar 

  • Stewart AD (1983) The role of the Y chromosome in mammalian sexual differentiation. In: Johnson MH (ed) Development in mammals, Elsevier, Amsterdam, pp 321–367

    Google Scholar 

  • Sutcliffe MJ, Bourgoyne PS (1989) Analysis of the testes of H-Y negative XOSxrb mice suggests that the spermatogenesis gene ( Spy) acts during the differentiation of the A spermatogonia. Development 107: 373–380

    Google Scholar 

  • Tiepolo L, Zuffardi 0 (1976) Localization of factors controlling spermatogenesis in the nonfluorescent portion of the human Y chromosome long arm. Hum Genet 34: 119–124

    CAS  Google Scholar 

  • Turner HH (1938) A syndrome of infantilism, congenital webbed neck and cubitus valgus. Endocrinology 23: 566–574

    Google Scholar 

  • Tyler-Smith C, Taylor L (1988) Structure of a hypervariable tandemly repeated DNA sequence on the short arm of the human Y chromosome. J Mol Biol 203: 837–848

    PubMed  CAS  Google Scholar 

  • Tyrkus M, Postellon D, Hoffman WH, Bawle E, Wooley PV (1979) Evidence for male determining loci on the Y chromosome. Am J Hum Gen 31: 113A

    Google Scholar 

  • Vergnaud G, Page DC, Simmler M-C, Brown L, Rouyer F, Noel B, Botstein D, de la Chapelle A, Weissenbach J (1986) A deletion map of the human Y chromosome based on DNA hybridization. Am J Hum Genet 38: 109–124

    PubMed  CAS  Google Scholar 

  • Vogt P (1992) Wurde die genetische Funktion des Y Chromosoms während der männlichen Keimzell-Entwicklung bisher unterschätzt ? Dt Ärztebl 89 (5A1): 294–295

    Google Scholar 

  • Vogt P, Keil R, Köhler MD, Lengauer C, Lewe D, Lewe G (1991a) Selection of DNA sequences from interval 6 of the human Y chromosome with homology to a Y chromosomal fertility gene sequence of Drosophila hydei. Hum Gen 86: 341–349

    CAS  Google Scholar 

  • Vogt P, Chandley AC, Hargreave TB, Keil R, Ma K, Sharkey A (199 lb) Towards the molecular localization of AZF, a male fertility gene on the human Y chromosome by cooperative mapping of microdeletions in the Y chromosome of men with idiopathic infertility. Am J Hum Genet 49: supplement

    Google Scholar 

  • Vogt P, Keil R, Köhler M, Tariverdian G, Chandley AC, Kun M, Sharkey A, Hargreave TB, Wegner R (1991c) In: Collins J, Driesel AJ (eds) Genome analysis: From sequence to function. Adv in Mol Gen 4: 277–280

    Google Scholar 

  • Vogt P, Chandley AC, Hargreave TB, Keil R, Ma K, Sharkey A (1992) Micro-deletions in interval 6 of the Y chromosome of azoospermic males points to a disruption of AZF, a human spermatogenesis gene. (submitted)

    Google Scholar 

  • Wachtel SS (1983) H-Y antigen and the biology of sex determination. Grune & Stratton, New York

    Google Scholar 

  • Wahlström J (1985) Y/Y translocations and their cytologic and clinical manifestations. In: Sandberg AA (ed) The Y chromosome, Part B: Clinical Aspects of Y chromosome abnormalities Alan R. Liss, New York pp 207–212

    Google Scholar 

  • Weissenbach J, Goodfellow PN (1990) Report of the committee on the genetic constitution of the Y chromosome. Cytogenet Cell Genet 55: 314–320

    PubMed  CAS  Google Scholar 

  • Weissenbach J, Goodfellow PN, Smith KD (1989) Report of the committee on the genetic constitution of the Y chromosome. Cytogenet Cell Genet 51: 438–449

    PubMed  CAS  Google Scholar 

  • Wiberg UH (1987) Facts and considerations about sex-specific antigens. Hum Genet 76: 207–219

    PubMed  CAS  Google Scholar 

  • Willison K, Ashworth A (1987) Mammalian spermatogenic gene expression. T I G 3: 351–355

    Google Scholar 

  • Wilson MG, Stein RB, Towner JW (1976) Ring Y chromosome without mosaicism. Birth Defects 12, 105–112

    PubMed  CAS  Google Scholar 

  • Yamada K, Nanko S, Hattori S, Isurugi K (1982) Cytogenetic studies in a Yto-X translocation observed in three members of one family, with evidence of infertility in male carriers. Hum Genet 60: 85–90

    PubMed  CAS  Google Scholar 

  • Yen PH, Marsh B, Allen E, Tsai SP, Ellison J, Conolly L, Neiswanger K, Shapiro LJ (1988) The human X-linked steroid sulfatase gene and a Y encoded pseudogene: evidence for an inversion of the Y chromosome during primate evolution. Cell 55: 1123–1135

    PubMed  CAS  Google Scholar 

  • Yunis E, Garcia-Conti L, Torres de Caballero OM, Giraldo A (1977) Yq deletion, aspermia, and short stature. Hum Genet 39: 117–122

    PubMed  CAS  Google Scholar 

  • Yunis JJ, Ball DW, Sawyer JR (1979) G-banding patterns of high-resolution human chromosomes 6–22,X, and Y. Hum Genet 49: 291–306

    PubMed  CAS  Google Scholar 

  • Zenzes MT, Wolf U, Engel W (1978) Organization in vitro of ovarian cells into testicular structures. Hum Genet 44: 333–338

    PubMed  CAS  Google Scholar 

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Authors
  1. Peter Vogt
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Editors and Affiliations

  1. Institute of Reproductive Medicine of the University, Steinfurter Str. 107, 4400, Münster, Germany

    Eberhard Nieschlag

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© 1992 Springer-Verlag Berlin Heidelberg

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Vogt, P. (1992). Y Chromosome Function in Spermatogenesis. In: Nieschlag, E., Habenicht, UF. (eds) Spermatogenesis — Fertilization — Contraception. Schering Foundation Workshop, vol 4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-02815-5_10

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  • DOI: https://doi.org/10.1007/978-3-662-02815-5_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-02817-9

  • Online ISBN: 978-3-662-02815-5

  • eBook Packages: Springer Book Archive

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