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Y Chromosome Function in Spermatogenesis

  • Peter Vogt
Part of the Schering Foundation Workshop book series (SCHERING FOUND, volume 4)

Abstract

In mammals a function of the Y chromosome during spermatogenesis has long been hidden by the sex determining function of the Y chromosome in this species class. In contrast to Drosophila, where a X,O-karyotype is compatible with a normal viable male, although sterile, in humans the same karyotype is related to a female with sterility and different phenotype abnormalities commonly known as Turner’s syndrome (Turner 1938). This state of affairs persisted until 1976, when Tiepolo and Zuffardi (1976) presented clear evidence that the human Y chromosome also must have a function in spermatogenesis. Analyzing a terminal deletion in the Y chromosome of six sterile males with a normal phenotype but azoospermia, they suggested a male fertility gene complex called azoospermia factor (AZF), and located to the distal region of the euchromatic part of the long Y arm (Yg11).

Keywords

Sertoli Cell Sterile Male Chromosome Function Cytogenet Cell Pseudoautosomal Region 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer-Verlag Berlin Heidelberg 1992

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  • Peter Vogt

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