Can Animal Models Be Used to Predict the Hemostasiologic Effect of Steroid Hormones in Man?

  • Andreas Süßmilch
  • Rupprecht Zierz
  • Karsten Parczyk
  • Krzystof Chwalisz
  • Karl-Heinrich Fritzemeier
  • Berthold Baldus
Conference paper
Part of the Schering Foundation Workshop book series (SCHERING FOUND, volume 5)

Abstract

Epidemiologic studies indicate an increased risk of thrombosis for users of oral contraceptives (OC) which is dose-dependent for the estrogen component (Böttiger et al. 1980; Melis et al. 1988; Gerstman et al. 1991). In order to evaluate this association, most clinical studies have concentrated on the assessment of plasmatic factors to demonstrate changes in the hemostatic system caused by OC.

Keywords

Catheter Estrogen Aspirin Glucocorticoid Bentonite 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Aronson DL, Thomas DP (1985) Experimental studies on venous thrombosis: effect of coagulants, procoagulants and vessel contusion. Thromb Haemost 54: 866–870PubMedGoogle Scholar
  2. Beato M (1989) Gene regulation by steroid hormones. Cell 56: 335–344PubMedCrossRefGoogle Scholar
  3. Beller FK, Ebert C (1985) Effects of oral contraceptives on blood coagulation: a review. Obstet Gynecol Sury 40: 425–436CrossRefGoogle Scholar
  4. Boettiger LE, Boman G, Eklund G, Westerholm B (1980) Oral contraceptives and thromboembolic disease: effects of lowering oestrogen content. Lancet 5: 1097–1101CrossRefGoogle Scholar
  5. Boisclair MD, Ireland H, Lane DA (1990) Assessment of hypercoagulable states by measurement of activation fragments and peptides. Blood Rev 4: 25–40PubMedCrossRefGoogle Scholar
  6. Bonnar J, Sabra AM (1986) Oral contraceptives and blood coagulation. J Repr Med 31: 551–556Google Scholar
  7. Burch JBE, Evans MI, Friedman TM, O’Malley PJ (1988) Two functional estrogen response elements are located upstream of the major chicken vitellogenin gene. Mol Cell Biol 8: 1123–1131PubMedGoogle Scholar
  8. Bush LR, Shebuski RJ (1990) In vivo models of arterial thrombosis and thrombolysis. FASEB J 4: 3087–3098PubMedGoogle Scholar
  9. Clauss VA (1957) Gerinnungsphysiologische Schnellmethode zur Bestimmung des Fibrinogens. Acta Haematol 17: 237–246PubMedCrossRefGoogle Scholar
  10. Daly L, Bonnar J (1990) Comparative studies of 30 µg ethinyl estradiol combined with gestodene and desogestrel on blood coagulation, fibrinolysis and platelets. Am J Obstet Gynecol 163: 430–437PubMedGoogle Scholar
  11. Emms H, Lewis GP (1985) The effect of synthetic ovarian hormones on an in vivo model of thrombosis in the rat. Br J Pharmacol 84: 243–248PubMedGoogle Scholar
  12. Feldmer M, Kaling M, Takahashi S, Mullins JJ, Ganten D (1991) Glucocorticoid-and estrogen-responsive elements in the 5’-flanking region of the rat angiotensinogen gene. J Hypertens 9: 1005–1012PubMedCrossRefGoogle Scholar
  13. Ganten D, Hellmann W, Klett C, Weimar-Ehl T, Feldmer M, Hackenthal E, Ryffel GU (1990) Differential actions of steroid hormones on the expression of the angiotensinogen gene expression. Eur J Pharmacol 183: 690CrossRefGoogle Scholar
  14. Gerstman BB, Piper JM, Tornita DK, Ferguson WJ, Stadel BV, Lundin FE (1991) Oral contraceptive estrogen dose and the risk of deep venous thromboembolic disease. Am J Epidemiol 133: 32–37PubMedGoogle Scholar
  15. Hladovec J (1986) Antithrombotics in view of thrombosis models. Thromb Res 43: 545–551PubMedCrossRefGoogle Scholar
  16. Inauen W, Baumgartner HR, Haeberli A, Straub PW (1987) Excessive deposition of fibrin, platelets and platelet thrombi on vascular subendothelium during contraceptive drug treatment. Thromb Haemost 57: 306–109PubMedGoogle Scholar
  17. Jespersen J, Petersen KR, Skouby SO (1990) Effects of newer oral contraceptives on the inhibition of coagulation and fibrinolysis in relation to dosage and type of steroid. Am J Obstet Gynecol 163: 396–403PubMedGoogle Scholar
  18. Kambuyashi J, Sakon M, Yokato M, Shiba E, Kawasaki T, Mori T (1990) Activation of coagulation and fibrinolysis during surgery, analyzed by molecular markers. Thromb Res 60: 157–167CrossRefGoogle Scholar
  19. Klein-Hitpaß L, Schorpp M, Wagner U, Ryffel GU (1986) An estrogen-responsive element derived from the 5’ flanking region of the Xenopus vitellogenin A2 gene functions in transfected human cells. Cell 46: 1053–1061PubMedCrossRefGoogle Scholar
  20. Kooistra T, Bosma PJ, Jespersen J, Kluft C (1990) Studies on the mechanism of action of oral contraceptives with regard to fibrinolytic variables. Am J Obstet Gynecol 163: 404–413PubMedGoogle Scholar
  21. Mammen EF (1982) Oral contraceptives and blood coagulation: a critical review. Am J Obstet Gynecol 142: 781–790PubMedGoogle Scholar
  22. Melis GB, Fruzzetti F, Paoletti AM, Carmassi F, Fioretti P (1984) Fibrinopeptide A plasma levels during low-estrogen oral contraception treatment. Thromb Res 30: 575–583Google Scholar
  23. Melis GB, Fruzetti F, Ricci C, Carmassi F, Fioretti P (1988) Oral contraceptives and venous thromboembolic disease: the effect of the oestrogen dose. Maturitas Suppl 1: 131–139CrossRefGoogle Scholar
  24. Murphy LJ, Friesen HG (1988) Differential effects of estrogen and growth hormone on uterine and hepatic insulin-like growth factor I gene expression in the ovariectomized hypophysectomized rat. Endocrinology 122: 325–332PubMedCrossRefGoogle Scholar
  25. Nawroth PP, Stern DM (1989) Das Endothel als zentrale Schaltstelle der Gerinnungskaskade. Z Kardiol 78: Suppl 6, 16–24Google Scholar
  26. Nawroth PP, Ziegler R (1991) Die Antibaby-Pille als Risikofaktor einer Thrombose: sind molekulare Mechanismen bekannt? Klin Wochenschr 69: 335–339PubMedCrossRefGoogle Scholar
  27. Millet J, Theveniaux J, Pascal M (1987) A new experimental model of venous thrombosis in rats involving partial stasis and slight endothelium alterations. Thromb Res 45: 123–133PubMedCrossRefGoogle Scholar
  28. Reel JR, McKenzie JS, Collins DW, Edgren RA (1983) Steroid-induced thrombogenesis in rats. Int J Fert 28: 169–172Google Scholar
  29. Reyers I, Mussoni L, Donati MB, deGaetano G (1989) Failure of aspirin at different doses to modify experimental thrombosis in rats. Thromb Res 18: 669–674CrossRefGoogle Scholar
  30. Skjonsberg OH, Kierulf P, Fagerhol MK, Godal HC (1986) Thrombin gener ation during collection and storage of blood. Vox Sang 50: 33–37PubMedCrossRefGoogle Scholar
  31. Smith JR, White AM (1982) Fibrin, red cell and platelet interactions in an ex perimental model of thrombosis. Br J Pharmacol 77: 029–033CrossRefGoogle Scholar
  32. Theiss W, Beller FK (1973) Stilbestrol-augmented disseminated intravascular coagulation in rats after infusion of endotoxin. Am J Obstet Gynecol 115: 775–782PubMedGoogle Scholar
  33. Thorogood M, Vessey MP (1990) An epidemiologic survey of cardiovascular disease in women taking oral contraceptives. Am J Obstet Gynecol 163: 274–281PubMedGoogle Scholar
  34. Virchow RLK (1856) Gesammelte Abhandlungen zur wissenschaftlichen Medizin. Meidinger, Frankfurt/MainGoogle Scholar
  35. Walenga JM, Fareed J, Mariani G, Messmore HL, Bick RL, Emanuele RM (1984) Diagnostic efficacy of a simple radioimmunoassay test for fibrinogen/fibrin fragments containing the B1315–42 sequence. Sem Thromb Haemost 10: 252–263CrossRefGoogle Scholar
  36. Wessler S (1989) The issue of animal models of thrombosis. Ann NY Acad Sci 556: 366–370PubMedCrossRefGoogle Scholar
  37. Wessler S, Connelly MT (1952) Studies in intravascular coagulation. I. Coagu lation changes in isolated venous segments. J Clin Invest 31: 1011–1014Google Scholar
  38. Winkler UH, Bühler K, Oberhoff C, Koslowski S, Hölscher T, Schindler AE (1991) Cyclic variation of haemostatic activities during the menstrual cycle: Modulation by low dose oral contraceptives. Abstract 1262, X III Congress of the International Society on Thrombosis and Haemostasis, AmsterdamGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • Andreas Süßmilch
  • Rupprecht Zierz
  • Karsten Parczyk
  • Krzystof Chwalisz
  • Karl-Heinrich Fritzemeier
  • Berthold Baldus

There are no affiliations available

Personalised recommendations