A Common Structural Pattern among Many Biologically Active Compounds of Both Natural and Synthetic Origin — A Novel Approach to the Design of Antineoplastic Agents

  • C. C. Cheng
Conference paper

Abstract

A tricyclic chemical structural pattern, consisting of a phenyl ring attached to the 2-position of a naphthalene nucleus, or composed of various heterocyclic units with similar molecular structural arrangements, is observed among a large number of biologically and pharmacologically active compounds. Possible relationships between this structural pattern and certain essential biomolecules are discussed. The pattern per se is not sufficient for attaining biological activity. It is believed that with proper substituents attached to specific positions of both ring units, compounds with desired biological activity could be rationally designed.

Keywords

Estrogen Anthracene Quinoline Benz Carbazole 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • C. C. Cheng
    • 1
  1. 1.Drug Development Laboratory and Department of PharmacologyToxicology & Therapeutics University of Kansas Medical CenterKansas CityUSA

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