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Stimulus Barrier Model of Schizophrenia: Convergence of Neurobiological and Developmental-Psychological Factors

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Schizophrenia and Youth

Abstract

A continuing problem in schizophrenia research concerns the interaction of genetic and environmental factors. Wynne and Cole (1985) published a diagrammatic representation of the interaction of these factors in relation to the possible risk for schizophrenia (Fig. 1).

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References

  • Ainsworth MDS, Bell SM (1969) Some contemporary patterns of mother-infant interaction in the feeding situation. In: Ambrose A (ed) Stimulation in early infancy. Academic, London

    Google Scholar 

  • Ainsworth MDS, Blehar M, Waters E, Wall S (1978) Patterns of attachment. A psychological study of the strange situation. Erlbaum, Hillsdale

    Google Scholar 

  • Averback P (1981) Lesion of the nucleus ansa peduncularis in neuropsychiatric disease. Arch Neurol 38: 230–235

    Article  PubMed  CAS  Google Scholar 

  • Benedetti G (1972) Ausgewählte Aufsätze zur Schizophrenielehre. Vandenhoeck & Ruprecht, Gottingen

    Google Scholar 

  • Benes FM, Davidson J, Bird ED (1986) Quantitative cytoarchitectural studies of the cerebral cortex of schizophrenics. Arch Gen Psychiatry 43: 31–35

    Article  PubMed  CAS  Google Scholar 

  • Berndl K, Grösser OJ, Martin M, Remschmidt H (1986) Comparative studies on recognition of faces, mimic and gestures in adolescent and middle-aged schizophrenic patients. Eur Arch Psychiatry Neurol Sci 236: 123–130

    Article  PubMed  CAS  Google Scholar 

  • Bickford-Wimer PC, Nagamoto H, Johnson R, Adler LE, Egan M, Rose GM, Freedman R (1990) Auditory sensory gating in hippocampal neurons: A model system in the rat. Biol Psychiatry 27: 183–192

    Article  PubMed  CAS  Google Scholar 

  • Bogerts B, Meertz E, Schonfeldt-Bausch R (1985) Basal ganglia and limbic system pathology in schizophrenia: a morphometric study. Arch Gen Psychiatry 42: 784–791

    Article  PubMed  CAS  Google Scholar 

  • Brazelton TB (1979) Behavioral competence of the newborn infant. Semin Perinatol 3: 35–44

    PubMed  CAS  Google Scholar 

  • Brown R, Colter N, Corsellis J, Crow TJ, Frith CD, Jagoe R, Johnstone EC, Marsh L (1986) Postmortem evidence of structural brain changes in schizophrenia. Arch Gen Psychiatry 43: 36–42

    Article  PubMed  CAS  Google Scholar 

  • Bzowej NH, Seeman P (1985) Age and dopamine D2 receptors in human brain. Soc Neurosci Abstr 11: 889

    Google Scholar 

  • Cannon TD, Mednick SA, Parnas J (1989) Genetic and perinatal determinants of structural brain deficits in schizophrenia. Arch Gen Psychiatry 46: 883–889

    Article  PubMed  CAS  Google Scholar 

  • Collis GM, Schaffer HR (1975) Synchronisation of visual attention in mother-infant pairs. J Child Psychol Psychiatry 16: 315–320

    Article  PubMed  CAS  Google Scholar 

  • Cramer P, Weegmann M, O’Neil M (1989) Schizophrenia and the perception of emotions. How accurately do schizophrenics judge the emotional states of others? Br J Psychiatry 155: 225–228

    Article  PubMed  CAS  Google Scholar 

  • Diatkine R, Stein C (1958) Les psychoses de l’enfance. L’évolution psychiatrique 3: 277–322

    Google Scholar 

  • Eggers C (1973) Verlaufsweisen kindlicher und präpuberaler Schizophrenien. Springer, Berlin Heidelberg New York

    Google Scholar 

  • Eggers C (1975) Die akute optische Halluzinose im Kindesalter. Klinische, differentialdiagnostische, neurophysiologische und entwicklungspsychologische Aspekte. Fortschr Neurol Psychiat 43: 441–470

    CAS  Google Scholar 

  • Eggers C (1981 a) Die Bedeutung limbischer Funktionsstörungen für die Ätiologie kindlicher Schizophrenien. Fortschr Neurol Psychiat 49: 101–108

    Google Scholar 

  • Eggers C ( 1981 b) Neuropsychologische Befunde bei kindlichen Schizophrenien. In: Remschmidt H, Schmidt M (eds) Neuropsychologie des Kindesalters. Enke, Stuttgart, pp 369–380

    Google Scholar 

  • Eggers C (1986) High-risk-Faktoren für die spätere Manifestation schizophrener Psychosen. In: Nissen G (ed) Psychiatrie des Jugendalters. Huber, Bern

    Google Scholar 

  • Eggers C (1988) Konvergentes Zusammenwirken neurobiologischer und entwicklungspsychologischer Bedingungsfaktoren. Reizschutzmodell der Schizophreniegenese In: Janzarik W (ed) Persönlichkeit und Psychose. Enke, Stuttgart, pp 38–46

    Google Scholar 

  • Erlenmeyer-Kimling L (1987) Biological markers for the liability to schizophrenia. In: Helmchen H, Henn FA (eds) Biological perspectives of schizophrenia. Wiley, Chichester, pp 33–56

    Google Scholar 

  • Gattaz WF, Kohlmeyer K, Gasser T (1987) Structural brain abnormalities in schizophrenia: an integrative model. In: Häfner H, Gattaz WF, Janzarik W (eds) Search for the causes of schizophrenia. Springer, Berlin Heidelberg New York, pp 250–259

    Chapter  Google Scholar 

  • Gillberg C, Wahlstrom J, Forsman A, Hellgren L, Gillberg IC (1986) Teenage psychoses — epidemiology, classification and reduced optimality in the pre- and perinatal periods. J Child Psychol Psychiatry 27: 87–96

    Article  PubMed  CAS  Google Scholar 

  • Gloor P (1986) Role of the human limbic system in perception, memory and affect. In: Doane BK, Livingston KE (eds) The limbic system. Raven, New York

    Google Scholar 

  • Goldmann PS (1967) Functional development of the prefrontal cortex in early life and the problem of neuronal plasticity. Exp Neurol 32: 366–387

    Article  Google Scholar 

  • Goldmann PS, Alexander GE (1977) Maturation of prefrontal cortex in the monkey revealed by local reversible cryogenic depression. Nature 267: 613–615

    Article  Google Scholar 

  • Goodman R (1988) Are complications of pregnancy and birth causes of schizophrenia? Dev Med Child Neurol 30: 391–394

    Article  PubMed  CAS  Google Scholar 

  • Gruzelier JH, Venables PH (1975) Relations between two-flash discrimination and electrodermal activity reexamined in schizophrenics and normals. J Psychiatry Res 12: 73–85

    Article  CAS  Google Scholar 

  • Holzmann PS, Proctor LR, Leva DL, Yasillo NJ, Meltzer HY, Hurt SW (1974) Eye tracking dysfunctions in schizophrenic patients and their relatives. Arch Gen Psychiatry 31: 143–151

    Article  Google Scholar 

  • Huttenlocher PR (1979) Synaptic density in human frontal cortex — developmental changes and effects of aging Brain Res 163: 195–205

    CAS  Google Scholar 

  • Iacono WG (1985) Psychophysiological markers of psychopathology: a review. Can Psychol 26: 96–112

    Article  Google Scholar 

  • Jaffe J, Stern DN, Peery JC (1973) Conversational complexity of gaze behaviour in prelinguistic human development. J Psycholing Res 2: 321–330

    Article  CAS  Google Scholar 

  • Jeste DV, Lohr JB (1989) Hippocampal pathologic findings in schizophrenia. A morphometric study. Arch Gen Psychiatry 46: 1019–1024

    Article  PubMed  CAS  Google Scholar 

  • Kaye K (1977) Towards the origin of dialogue. In: Schaffer HR (ed) Studies in mother-infant interaction. Academic, London

    Google Scholar 

  • Kirch DG, Weinberger DR (1986) Anatomical neuropathology in schizophrenia: post-mortem findings. In: Nasrallah HA, Weinberger DR (eds) The neurology of schizophrenia. Elsevier, Amsterdam, pp 325–348

    Google Scholar 

  • Kovelman JA, Scheibel AG (1984) A neurohistological correlate of schizophrenia. Biol Psychiatry 19: 1601–1621

    PubMed  CAS  Google Scholar 

  • Lempp R (1973) Psychosen im Kindes- and Jugendalter — eine Realitätsbezugsstörung. Huber, Bern

    Google Scholar 

  • Lesch A, Bogerts B (1984) The diencephalon in schizophrenia: evidence for reduced thickness of the periventricular grey matter. Eur Arch Psychiatry Neurol Sci 234: 212–219

    Article  PubMed  CAS  Google Scholar 

  • McGeer PL, McGeer ED (1981) Neurotransmitters in the aging brain. In: Darrison AM, Thompson RH (eds) The molecular basis of neuropathology. Arnold, London, pp 631–648

    Google Scholar 

  • Mednick SA, Schulsinger F (1973) A learning theory of schizophrenia: thirteen years later. In: Hammer M, Salzinger K, Sutton S (eds) Psychopathology: contributions from the social behavioural and biological sciences. Wiley, New York

    Google Scholar 

  • Mednick SA, Machon RA, Huttunen MO, Bonett D (1988) Adult schizophrenia following prenatal exposure to an influenza epidemic. Arch Gen Psychiatry 45: 189–192

    Article  PubMed  CAS  Google Scholar 

  • Meisami E, Firoozi M (1985) Acetylcholinesterase activity in the developing olfactory bulb: a biochemical study on normal maturation and the influence of peripheral and central connections. Dev Brain Res 21: 115–124

    Article  CAS  Google Scholar 

  • Mentzos S (1986) Drei therapeutische Settings in der psychoanalytischen Psychotherapie psychotischer Patienten. Forum Psychoanal 2: 134–151

    Google Scholar 

  • Miller R (1989) Cortico-hippocampal interplay: self-organizing phase-locked loops for indexing memory. Psychobiol 17: 115–128

    Google Scholar 

  • Morstyn R, Duffy FH, McCarley RW (1983) Altered P300 topography in schizophrenia. Arch Gen Psychiatry 40: 729–734

    Article  PubMed  CAS  Google Scholar 

  • Nieto D, Escobar A (1972) Major psychoses. In: Minkler J (ed) Pathology of the nervous system. McGraw-Hill, New York, pp 2654–2665

    Google Scholar 

  • Nuechterlein KH, Dawson ME (1984) Information processing and attentional functioning in the developmental course of schizophrenic disorders. Schizophr Bull 10: 160–302

    Article  PubMed  CAS  Google Scholar 

  • O’Kusky JR (1985) Synapse elimination in the developing visual cortex: a morphometric analysis in normal and dark-reared cats. Dev Brain Res 22: 81–91

    Article  Google Scholar 

  • Papousek M, Papousek H (1981) Neue Wege der Verhaltensbeobachtung und Verhaltensmikroanalyse. Sozialpädiatrie 3: 20–22

    Google Scholar 

  • Pycock CJ, Kerwin RW, Carter CJ (1980) Effect of lesion of cortical dopamine terminals on sub-cortical dopamine in rats. Nature 286: 74–77

    Article  PubMed  CAS  Google Scholar 

  • Reynolds GP (1989) Beyond the dopamine hypothesis. The neurochemical pathology of schizophrenia. Br J Psychiatry 155: 305–316

    PubMed  CAS  Google Scholar 

  • Saitoh O, Niwa S, Hiramatsu K, Kameyama T, Rymar K, Itoh K (1984) Abnormalities in late positive components of event-related potentials may reflect a genetic predisposition to schizophrenia. Biol Psychiatry 19: 293–303

    PubMed  CAS  Google Scholar 

  • Schaffer R (1982) Mütterliche Fürsorge in den ersten Lebensjahren. Das Kind und seine Entwicklung. Klett-Cotta, Stuttgart

    Google Scholar 

  • Shakow D (1962) Segmental set. A theory of the formal psychological deficit in schizophrenia. Arch Gen Psychiatry 6: 1–17

    Article  PubMed  CAS  Google Scholar 

  • Siever LJ, Coursey RD (1985) Biological markers for schizophrenia and the biological high risk approach. J Nerv Ment Dis 173: 4–16

    Article  PubMed  CAS  Google Scholar 

  • Süllwold L (1977) Symptome schizophrener Erkrankungen. Uncharakteristische Basisstörungen. Springer, Berlin Heidelberg New York ( Monographien aus dem Gesamtgebiet der Psychiatrie/Psychiatry Series, Band 13 )

    Google Scholar 

  • Stern D (1977) The first relationship. Harvard University Press, Cambridge

    Google Scholar 

  • Stevens JR (1982) Neuropathology of schizophrenia. Arch Gen Psychiatry 39: 1131–1139

    Article  PubMed  CAS  Google Scholar 

  • Strandburg RJ, Marsh JT, Brown WS, Asarnow RF, Guthrie D (1984) Event-related potential concomitants of information processing dysfunction in schizophrenic children. Electroencephalogr Clin Neurophysiol 57: 236–253

    Article  PubMed  CAS  Google Scholar 

  • Straube E (1979) On the meaning of electrodermal non-responding in schizophrenia. J Nerv Ment Dis 167: 601–611

    Article  PubMed  CAS  Google Scholar 

  • Tienari P, Lahti I, Sorri A, Naarala M, Moring J, Wahlberg KE (1989) The Finnish adoptive family study of schizophrenia. Possible joint effects of genetic vulnerability and family environment. Br J Psychiatry 155: 29–32

    Google Scholar 

  • Tucker TJ, Kling A (1967) Differential effects of early and late lesions of frontal granular cortex in the monkey. Brain Res 5: 377–389

    Article  Google Scholar 

  • Venables PH (1989) The Emanuel Miller memorial lecture 1987. Childhood markers for adult disorders. J Child Psychol Psychiatry 30: 347–364

    Article  PubMed  CAS  Google Scholar 

  • Vinogradova OS (1975) Functional organization of the limbic system in the process of registration of information: facts and hypotheses. In: Isaacson RL, Pribram KH (eds) The hippocampus, vol 2: Neurophysiology and behavior. Plenum, New York

    Google Scholar 

  • Weinberger R (1987) Implications of normal brain development for the pathologenesis of schizophrenia. Arch Gen Psychiat 44: 660–669

    Article  PubMed  CAS  Google Scholar 

  • Wynne LC, Cole RE (1985) Das Rochester-Risikoforschungsprogramm. Die Diagnosen der Eltern und die Familienbeziehungen in neuer Sicht. In: Stierlin H, Wynne LC, Wirsching M (eds) Psychotherapie und Sozialtherapie der Schizophrenie. Ein internationaler Überblick. Springer, Berlin Heidelberg New York

    Google Scholar 

  • Yakolev PI, Le Cours AR (1964) The myelogenetic cycles of regional maturation of the brain. In: Minkowski A (ed) Regional development of the brain in early life. Blackwell, Boston, pp 3–70

    Google Scholar 

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Authors
  1. C. Eggers
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Editors and Affiliations

  1. Klinik für Kinder- und Jugendpsychiatrie, Rheinische Landes- u. Hochschulklinik, Hufelandstraße 55, 4300, Essen, Germany

    Christian Eggers (Direktor) (Direktor)

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Eggers, C. (1991). Stimulus Barrier Model of Schizophrenia: Convergence of Neurobiological and Developmental-Psychological Factors. In: Eggers, C. (eds) Schizophrenia and Youth. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-02684-7_4

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  • DOI: https://doi.org/10.1007/978-3-662-02684-7_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-52485-4

  • Online ISBN: 978-3-662-02684-7

  • eBook Packages: Springer Book Archive

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