The Severity of Convulsive Behaviour in Rats: Disinhibitory Effects of Cortical Lesions

Conference paper


The inhibitory neurotransmitter GABA is widely distributed within the cerebral cortex (Ottersen and Storm-Mathisen 1984). It mediates the self-inhibitory action within the cortex, thus suppressing and stabilizing cortical activity. A decrease in the intrinsic inhibitory action increases the excitability of the cortex. Due to the widespread intra- and interhemispheric connections (Brodal 1981; Praxinos 1985), substantial lesions not only counteract the stabilizing mechanisms used for the balance of cortical activity but also decrease the amount of intrinsic cortical inhibition, leading to more pronounced cortical and/or behavioural defects during periods of cerebral disturbances, even if the lesioned area is far away from the area responsible for perception or behavioural response.


Motor Cortex Cortical Lesion Spontaneous Seizure Convulsive Activity Somatosensory Area 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • E. Horn
    • 1
  1. 1.Abteilung für NeurologieUniversität UlmUlmGermany

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