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Searching for New Antiischemic Compounds: Theoretical and Practical Aspects

  • B. Wilffert
  • T. Peters
Conference paper

Abstract

Many substances act in an antiischemic manner, e g membrane-stabilizing drugs, cationic amphiphilic compounds,such as β-sympathicolytics, local anesthetics and all agents that suppress cardiac function, e.g. calcium entry blockers. However, high concentrations are necessary, and the side effects are pronounced. It would be desirable to find agents which affect only the pathophysiological processes observed during ischemia without influencing physiological processes. The optimal stage of interaction would be early in the ischemic cascade.

Keywords

Calcium Entry Blocker Ischemic Cascade Contractile Process Sodium Overload Janssen Research Foundation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • B. Wilffert
    • 1
  • T. Peters
    • 1
  1. 1.Janssen Research FoundationNeuss 21Germany

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