Abstract
Many substances act in an antiischemic manner, e g membrane-stabilizing drugs, cationic amphiphilic compounds,such as β-sympathicolytics, local anesthetics and all agents that suppress cardiac function, e.g. calcium entry blockers. However, high concentrations are necessary, and the side effects are pronounced. It would be desirable to find agents which affect only the pathophysiological processes observed during ischemia without influencing physiological processes. The optimal stage of interaction would be early in the ischemic cascade.
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© 1990 Springer-Verlag Berlin Heidelberg
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Wilffert, B., Peters, T. (1990). Searching for New Antiischemic Compounds: Theoretical and Practical Aspects. In: Deecke, L., Eccles, J.C., Mountcastle, V.B. (eds) From Neuron to Action. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-02601-4_64
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DOI: https://doi.org/10.1007/978-3-662-02601-4_64
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