Searching for New Antiischemic Compounds: Theoretical and Practical Aspects

  • B. Wilffert
  • T. Peters
Conference paper


Many substances act in an antiischemic manner, e g membrane-stabilizing drugs, cationic amphiphilic compounds,such as β-sympathicolytics, local anesthetics and all agents that suppress cardiac function, e.g. calcium entry blockers. However, high concentrations are necessary, and the side effects are pronounced. It would be desirable to find agents which affect only the pathophysiological processes observed during ischemia without influencing physiological processes. The optimal stage of interaction would be early in the ischemic cascade.


Calcium Entry Blocker Ischemic Cascade Contractile Process Sodium Overload Janssen Research Foundation 
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  1. Akerman KEO, Heinonen E (1983) Qualitative measurements of cytosolic calcium ion concentration within isolated guinea-pig nerve endings entrapped arsenazo III. Biochim Biophys Acta 732: 117–121PubMedCrossRefGoogle Scholar
  2. Borchard M, Ravens U (1986) Intracellularly applied sodium mimics the effects of ouabain in single cardiac myocytes. Eur J Pharmacol 131: 269–272PubMedCrossRefGoogle Scholar
  3. Coetzee WA, Opie LH, Saman S (1987) Proposed role of energy supply in the genesis of delayed afterdepolarizations implications for ischemic or reperfusion arrhythmias. J Mol Cell Cardiol [Supp 5] 19: 13–21PubMedCrossRefGoogle Scholar
  4. Fabiato A (1985) Use of aequorin for the appraisal of the hypothesis of the release of calcium from the sar- coplasmic reticulum induced by a change of pH in skinned cardiac cells. Cell Calcium 6: 95–108PubMedCrossRefGoogle Scholar
  5. Höller H, Dierldng H, Dengler K, Tegtmeier F, Peters T (1986) Effect of flunarizine on extracellular ion concentration in the rat brain under hypoxia and ischemia. In: Battistini N, Courbier E, et al. (eds) Acute brain ischemia medical and surgical therapy. Raven, pp 229–236Google Scholar
  6. Lüllmann H, Peters T (1977) Plasmalemmal calcium in cardiac excitation-contraction coupling. Clin Exp Pharmacol Physiol 4: 49–57PubMedCrossRefGoogle Scholar
  7. Peters T (1986a) Calcium in physiological and pathological cell function. Eur Neurol[Suppl 1] 25: 27. 44Google Scholar
  8. Peters T (1986b) Glycoside receptors in the heart. Prog Pharmacol 6: 65–80Google Scholar
  9. Post JA, Langer GA, Op den Kamp J, Verkleij AJ (1988) Phospholipid assymetry in cardiac sarcolemma. Analysis of intact cells and ‘gas dissected’ membranes. Biochim Biophys Acta 943: 256–266Google Scholar
  10. Smith TW (1988) Digitalis. Mechanism of action and clinical use. N Engl J Med 318: 358–365PubMedCrossRefGoogle Scholar
  11. Sperelakis N (1988) Regulation of calcium slow channels of cardiac muscle by cyclic nucleotides and phosphorylation. J Mol Cell Cardiol[Suppl 2] 20: 75–105CrossRefGoogle Scholar
  12. Vollmer B, Meuter C, Janssen PAJ (1987) R 56865 prevents electrical and mechanical signs of ouabain intoxication in guinea-pig papillary muscle. Eur J Pharmacol 142: 137–140PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • B. Wilffert
    • 1
  • T. Peters
    • 1
  1. 1.Janssen Research FoundationNeuss 21Germany

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