Do the Pretectum and Accessory Optic System Play Different Roles in Optokinetic Nystagmus?

  • M. J. Mustari
  • A. F. Fuchs
Conference paper

Abstract

Recent studies in birds and lower mammals have implicated the accessory optic system (AOS) and NOT in the generation of slow eye movements, especially OKN (reviewed by Simpson 1984). Single units in these structures respond to both the direction and velocity of full-field visual stimuli, and lesions of these structures compromise OKN. Both the AOS, which consists of lateral, medial, and dorsal terminal nuclei (LTN, MTN, DTN), and the NOT receive direct retinal input from the contralateral eye. Single units in the LTN and MTN prefer vertical visual motion (Simpson et al. 1979; Grasse and Cynader 1982, 1984; Mustari et al. 1986) whereas those in the DTN and NOT prefer horizontal visual motion (Grasse and Cynader 1984; Collewijn 1975; Hoffmann and Schoppmann 1981; Hoffmann and Distler 1986; Mustari and Fuchs 1988). One pathway by which the AOS and NOT could influence eye movements is via a projection to that part of the inferior olive (IO), the dorsal cap of Kooy, that supplies climbing fibers to the flocculus (Maekawa and Simpson 1973). The flocculus is known to have a role in smooth-pursuit (Lisberger and Fuchs 1978) and optokinetic (Zee et al. 1981; Waespe et al. 1985) eye movements.

Keywords

Retina Proline Leucine Schiff Allo 

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References

  1. Cohen B, Matsuo V, Raphan T (1977) Quantitative analysis of the velocity characteristics of optokinetic nystagmus and optokinetic after-nystagmus. J Physiol (Lond) 270: 321–344Google Scholar
  2. Collewijn H (1975) Direction-selective units in the rabbit’s nucleus of the optic tract. Brain Res 100: 489–508PubMedCrossRefGoogle Scholar
  3. Cooper HM, Magnin M (1986) A common mammalian plan of accessory optic system organization revealed in all primates. Nature 324: 457–459PubMedCrossRefGoogle Scholar
  4. Cowan WM, Gottlieb DI, Hendrickson AE, Price JL, Woolsey TA (1972) The autoradiographic demonstration of axonal connections in the CNS. Brain Res 37: 21–51PubMedCrossRefGoogle Scholar
  5. Grasse KL, Cynader MS (1982) Electrophysiology of the medial terminal nucleus of the accessory optic system in the cat. J Neurophysiol 48: 490–504PubMedGoogle Scholar
  6. Grasse KL, Cynader MS (1984) Electrophysiology of the lateral and dorsal terminal nuclei of the cat accessory optic system. J Neurophysiol 51: 276–293PubMedGoogle Scholar
  7. Hoffmann KP, Schoppmann A (1981) A quantitative analysis of the directionspecific response of neurons in the cat’s nucleus of the optic tract. Exp Brain Res 51: 236–246Google Scholar
  8. Hoffmann KP, Distler C (1986) The role of direction selective cells in the nucleus of the optic tract of cat and monkey during optokinetic nystagmus. Adv Biosci 57: 261–266Google Scholar
  9. Lisberger SG, Fuchs AF (1978) Role of the flocculus in rapid behavioral modification of the vestibuloocular reflex. I. Purldnje cell activity during visually guided horizontal smooth-pursuit eye movements and passive head rotation. J Neurophysiol 41: 733–763Google Scholar
  10. Maekawa K, Simpson JI (1973) Climbing fiber responses evoked in the vestibulocerebellum of the ‘rabbit from the visual system. J Neurophysiol 36: 649–666PubMedGoogle Scholar
  11. Matsuo V, Cohen B (1984) Vertical optokinetic nystagmus and vestibular nystagmus in the monkey: up-down asymmetry and effects of gravity. Exp Brain Res 53: 197–216PubMedCrossRefGoogle Scholar
  12. Mesulum MM (1978) TMß for HRP neurochemistry: A non-carcinogenic blue reaction product with superior sensitivity for visualizing neural afferents and efferents. J Histochem Cytochem 26: 106–117CrossRefGoogle Scholar
  13. Mustari MJ, Fuchs AF (1988) The response properties of units in the pretectal nucleus of the optic tract in the behaving monkey. Soc Neurosci 14: 955Google Scholar
  14. Mustari MJ, Fuchs AF, Waliman J, Langer TP, Kaneko CRS (1986)Visual and oculomotor response properties of single units in the lateral terminal nucleus (LTN) of the behaving rhesus monkey. Soc Neurosci 12: 459Google Scholar
  15. Mustari MJ, Fuchs AF, Wallmann J (1988) Smooth-pursuit-related units in the dorsolateral pons of the rhesus macaque: J Neurophysiol 60: 664–686Google Scholar
  16. Schiff D, Cohen B, Raphan T (1988) Stimulation of the nucleus of the optic tract ( NOT) induces nystagmus in the monkey. Exp Brain Res 70: 1–14Google Scholar
  17. Simpson JI (1984) The accessory optic system. Ann Rev Neurosci 7: 13–41PubMedCrossRefGoogle Scholar
  18. Simpson JI, Soodak RE, Hess R (1979) The accessory optic system and its relationship to the vestibulo-cerebellum. In: Progr Brain Res 50: 715–724Google Scholar
  19. Waespe W, Rudinger D, Wolfensberger M (1985) Purkinje cell activity in the flocculus of vestibular neurectomized and normal monkeys during optokinetic nystagmus ( OI(N) and smooth pursuit eye movements. Exp Brain Res 60: 243–262Google Scholar
  20. Wallman J, Velez J (1985) Directional asymmetries of optokinetic nystagmus: developmental changes and relation to the accessory optic system and the vestibular system. J Neurosci 5: 317–329PubMedGoogle Scholar
  21. Weber JT, Giolli RA (1986) The medial terminal nucleus of the monkey: evidence for a complete accessory optic system. Brain Res 365: 164–168PubMedCrossRefGoogle Scholar
  22. Zee DS, Yamazaki A, Butler PH, Gucer G (1981) Effects of ablation of flocculus and paraflocculus on eye movements in primate. J Neurophysiol 46: 878–899PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • M. J. Mustari
    • 1
  • A. F. Fuchs
    • 1
  1. 1.Department of Physiology and Biophysics and Regional Primate Research CenterUniversity of WashingtonSeattleUSA

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