Significance of Carbonic Anhydrase in the Function of Skeletal Muscle
To look into the function of CA, we have started our work with the excised frog gastrocitemius muscle with its nerve supply intact (Scheid and Siffert 1985). The muscle was suspended in air in an apparatus that allowed measurement of single-twitch isometric force. After a control, the muscle of one body side was incubated in frog Ringer’s solution containing one of the CA inhibitors, acetazolamide, ethoxzolamide, or methazolamide; the muscle of the other body side was incubated, as control, in Ringer’s solution without inhibitor.
KeywordsCarbonic Anhydrase Extensor Digitorum Longus Isometric Force Transmitter Release Neuromuscular Transmission
Unable to display preview. Download preview PDF.
- Clemens N, Siffert W, Scheid P (1986) Effects of carbonic anhydrase inhibitors on isometric force of rat skeletal muscle. Pflügers Arch 406: R 29Google Scholar
- Riley DA, Ellis S, Bain J (1982) Carbonic anhydrase activity in skeletal muscle fiber types, axons, spindles, and capillaries of rat soleus and extensor digitorum longus muscles. J Histochem Cytochem 30: 1275–1. 288Google Scholar
- Riley DA, Ellis S, Bain (1984) Ultrastructural cytochemical localization of carbonic anhydrase activity in rat peripheral sensory and motor nerves, dorsal root ganglia, and dorsal column nuclei. Neuroscience 13: 189–206Google Scholar
- Scheid P, Siffert W (1985) Effects of inhibiting carbonic anhydrase on isometric contraction of frog skeletal muscle. J Physiol (Lond) 361: 91–101Google Scholar