Marchiafava-Bignami syndrome (MBS) is a primary degeneration of the corpus callosum occurring in chronic alcoholics. Although a high proportion of reported cases have been Italians, drinking Italian wine, the condition has also been described in many non-Italians drinking non-Italian wine. Most affected cases were middle-aged men whose daily wine consumption had been 2 1 or more for many years. The disease knows three major clinical forms: acute, subacute, and chronic.
KeywordsWhite Matter Corpus Callosum Anterior Commissure Centrum Semiovale Glial Reaction
Unable to display preview. Download preview PDF.
- Allen IV (1984) Demyelinating diseases. In: Hume Adams J, Corsellis JAN, Duchen LW, eds. Greenfield’s Neuropathology, 4th ed. London: Edward Arnold: 338–384Google Scholar
- Brion S (1976) Marchiafava-Bignami syndrome. In: Vinken PJ, Bruyn GW, eds. Handbook of clinical neurology, vol 28. Amsterdam: North Holland Publishing Company: 317–329Google Scholar
- Duchen LW, Jacobs JM (1984) Nutritional deficiencies and metabolic disorders. In: Hume Adams J, Corsellis JAN, Duchen LW, eds. Greenfield’s Neuropathology, 4th ed. London: Edward Arnold: 573–602Google Scholar