Marchiafava-Bignami Syndrome

  • Jacob Valk
  • Marjo S. van der Knaap


Marchiafava-Bignami syndrome (MBS) is a primary degeneration of the corpus callosum occurring in chronic alcoholics. Although a high proportion of reported cases have been Italians, drinking Italian wine, the condition has also been described in many non-Italians drinking non-Italian wine. Most affected cases were middle-aged men whose daily wine consumption had been 2 1 or more for many years. The disease knows three major clinical forms: acute, subacute, and chronic.


White Matter Corpus Callosum Anterior Commissure Centrum Semiovale Glial Reaction 
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  1. Allen IV (1984) Demyelinating diseases. In: Hume Adams J, Corsellis JAN, Duchen LW, eds. Greenfield’s Neuropathology, 4th ed. London: Edward Arnold: 338–384Google Scholar
  2. Bracard S, Claude D, Vespignani H, Aimeras M, et al. (1986) Scanographie et IRM de la maladie de MarchiafavaBignami. J Neuroradiol 13: 87–94PubMedGoogle Scholar
  3. Brion S (1976) Marchiafava-Bignami syndrome. In: Vinken PJ, Bruyn GW, eds. Handbook of clinical neurology, vol 28. Amsterdam: North Holland Publishing Company: 317–329Google Scholar
  4. Clavier E, Thiebot J, Delangre T, Hannequin D, et al. (1986) Marchiafava-Bignami disease. Neuroradiology 28: 376PubMedCrossRefGoogle Scholar
  5. Duchen LW, Jacobs JM (1984) Nutritional deficiencies and metabolic disorders. In: Hume Adams J, Corsellis JAN, Duchen LW, eds. Greenfield’s Neuropathology, 4th ed. London: Edward Arnold: 573–602Google Scholar
  6. Mayer JM, Liège de P, Netter JM, Danzé F, et al. (1987) Imagerie par tomodensitométrie et résonance magnétique dans la maladie de Marchiafava-Bignami. J Neuroradiol 14: 152–158PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • Jacob Valk
    • 1
  • Marjo S. van der Knaap
    • 2
  1. 1.Department of Diagnostic Radiology and NeuroradiologyFree University HospitalAmsterdamThe Netherlands
  2. 2.Department of Child NeurologyAcademic HospitalUtrechtThe Netherlands

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