Abstract
Subacute sclerosing panencephalitis (SSPE) is one of the slow virus infections of the CNS. It is a rare disorder, but it is the commonest of the chronic virus infections to affect children. It is caused by measles virus. SSPE is a disease of childhood and adolescence, with an age range of 4–20 years and a peak incidence at 7–10 years. There is a racial difference in incidence of SSPE: in the United States the incidence is four times higher in Whites than in Blacks. Boys outnumber girls by 3 or 2 to 1. Children who acquire measles infection under 2 years of age are more likely to develop SSPE. The mean age of infection is 12–14 months. SSPE can also occur after live measles vaccination.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Choppin PW (1981) Measles virus and chronic neurological diseases. Ann Neurol 9: 17–20
Dhib-Jalbut S, Haddad FS (1984) Subacute sclerosing pan-encephalitis in one member of identical twins. Neuropediatrics 15: 49–51
Dyken PR (1985) Subacute sclerosing panencephalitis. Neurol Clin 3: 179–196
Fournier JG, Tardieu M, Lebon P, Robain O, et al. (1985) Detection of measles virus RNA in lymphocytes from peripheral-blood and brain perivascular infiltrates of patients with subacute sclerosing panencephalitis. N Engl J Med 313: 910–915
Geller TJ, Vern BA, Sarwar M (1987) Focal MRI findings in early SSPE. Pediatr Neurol 3: 310–312
Griffith JF (1985) Subacute sclerosing panencephalitis and lymphocytes. N Engl J Med 313: 952–954
Hall WW, Choppin PW (1981) Measles-virus proteins in the brain tissue of patients with subacute sclerosing pan-encephalitis. N Engl J Med 304: 1152–1155
Jabbour JT, Garcia JH, Lemmi H, Ragland J, et al. (1969) Subacute sclerosing panencephalitis. JAMA 207: 2248–2254
Johnson KP, Byington DP, Gaddis L (1974) Subacute sclerosing panencephalitis. Adv Neurol 6: 77–86
Lum GB, Williams JP, Dyken PR, Machen BC, et al. (1986) Magnetic resonance and CT imaging correlated with clinical status in SSPE. Pediatr Neurol 2: 75–79
Meulenter V, Hall WW (1978) Slow virus infections of the nervous system: virological immunological and pathogenetic considerations. J Gen Virol 41: 1–25
Noetzel MJ, Dodson WE (1983) Progressive CT abnormalities despite clinical improvement in SSPE treated with inosiplex. Ann Neurol 13: 457–460
Ohya T, Martinez AJ, Jabbour JT, Lemmi H, et al. (1974) Subacute sclerosing panencephalitis. Neurology 24: 211–218
Payne FE, Baublis JV, Itabashi HH (1969) Isolation of measles virus from cell cultures of brain from a patient with subacute sclerosing panencephalitis. N Engl J Med 281: 585–589
Scully RE, Mark EJ, McNeely BU (1986) Case records of the Massachusetts general hospital. N Engl J Med 314: 1689–1700
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 1989 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Valk, J., van der Knaap, M.S. (1989). Subacute Sclerosing Panencephalitis. In: Magnetic Resonance of Myelin, Myelination, and Myelin Disorders. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-02568-0_35
Download citation
DOI: https://doi.org/10.1007/978-3-662-02568-0_35
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-662-02570-3
Online ISBN: 978-3-662-02568-0
eBook Packages: Springer Book Archive