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Basischer Fibroblasten-Wachstumsfaktor: Möglicher Beitrag zur Pathogenese und Therapie der Arteriosklerose

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Wachstumsfaktoren und Onkogenprodukte bei Entstehung und Regression der Arteriosklerose

Part of the book series: Veröffentlichungen aus der Geomedizinischen Forschungsstelle ((1149,volume 1988 / 1988/3))

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Zusammenfassung

Der basische Fibroblasten-Wachstumsfaktor wurde 1974 erstmals von Gospoda-rowicz in Hypophysen nachgewiesen [1]. Da der Faktor 1. einen basischen isoelektrischen Punkt besaß und 2. die Proliferation von Fibroblasten stimulierte, nannte Gospodarowicz ihn „basic fibroblast growth factor“ [1], im folgenden mit bFGF bezeichnet.

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Literatur

  1. Gospodarowicz D (1974) Localisation of a fibroblast growth factor and its effect alone and with hydrocortisone on 3T3 cell growth. Nature 249:123–127

    Article  PubMed  CAS  Google Scholar 

  2. Abraham JA, Whang JL, Tumolo A, Fiddes JC (1986) Human basic fibroblast growth factor: Nucleotide sequence, genomic organization, and expression in mammalian cells. Cold Spring Harbor Symp Quant Biol LI:657–668

    Article  Google Scholar 

  3. Schweigerer L, Neufeld G, Friedman J, Abraham JA, Fiddes JC, Gospodarowicz D (1987) Capillary endothelial cells express basic fibroblast growth factor, a mitogen that promotes their own growth. Nature 325:257–259

    Article  PubMed  CAS  Google Scholar 

  4. Schweigerer L, Neufeld G, Mergia A, Abraham JA, Fiddes JC, Gospodarowicz D (1987) Basic fibroblast growth factor in human rhabdomyosarcoma cells: Implications for the proliferation and neovascularization of myoblast-derived tumors. Proc Natl Acad Sci USA 84:842–846

    Article  PubMed  CAS  Google Scholar 

  5. Gospodarowicz D, Neufeld G, Schweigerer L (1986) Fibroblast growth factor. Mol Cell Endocrinol 46:187–204

    Article  PubMed  Google Scholar 

  6. Klagsbrun M, Smith S, Sullivan R, Shing Y, Davidson S, Smith JA, Sasse J(1987) Multiple forms of basic fibroblast growth factor: Amino-terminal cleavages by tumor cell and brain cell-derived acid proteinases. Proc Natl Acad Sci USA 84:1839–1843

    Article  PubMed  CAS  Google Scholar 

  7. Ferrara N, Schweigerer L, Neufeld G, Mitchell R, Gospodarowicz D (1987) Pituitary follicular cells produce basic fibroblast growth factor. Proc Natl Acad Sci USA 84:5773–5777

    Article  PubMed  CAS  Google Scholar 

  8. Pettmann B, Labourdette G, Weibel M, Sensenbrenner M (1986) The brain fibroblast growth factor is localized in neurons. Neurosci Lett 68:175–180

    Article  PubMed  CAS  Google Scholar 

  9. Schweigerer L, Malerstein B, Neufeld G, Gospodarowicz D (1987) Basic fibroblast growth factor is synthesized in cultured retinal pigment epithelial cells. Biochem Biophys Res Commun 143:934–940

    Article  PubMed  CAS  Google Scholar 

  10. Schweigerer L, Neufeld G, Friedman J, Abraham JA, Fiddes JC, Gospodarowicz D (1987) Basic fibroblast growth factor: Production and growth stimulation in cultured adrenal cortex cells. Endocrinology 120:796–800

    Article  PubMed  CAS  Google Scholar 

  11. Schweigerer L, Ferrara N, Neufeld G, Gospodarowicz D (1988) Basic fibroblast growth factor: Expression in cells derived from corneal endothelium and lens epithelium. Exp Eye Res 46:71–80

    Article  PubMed  CAS  Google Scholar 

  12. Gospodarowicz D, Ferrara N, Schweigerer L, Neufeld G (1987) Structural characterization and biological functions of fibroblast growth factor. Endocrine Rev 8:95–114

    Article  CAS  Google Scholar 

  13. Neufeld G, Ferrara N, Schweigerer L, Mitchell R, Gospodarowicz D (1987) Bovine granulosa cells produce basic fibroblast growth factor. Endocrinology 121:597–603

    Article  PubMed  CAS  Google Scholar 

  14. Schweigerer L, Neufeld G, Gospodarowicz D (1987) Basic fibroblast growth factor is present in cultured human retinoblastoma cells. Invest Ophthalmol Vis Sci 28:1838–1843

    PubMed  CAS  Google Scholar 

  15. Schweigerer L, Neufeld G, Gospodarowicz D (1987) Basic fibroblast growth factor as a growth inhibitor for cultured human tumor cells. J Clin Invest 80:1516–1520

    Article  PubMed  CAS  Google Scholar 

  16. Togari A, Baker D, Dickens G, Guroff G (1983) The neurite-promoting effect of fibroblast growth factor on PC-12 cells. Biochem Biophys Res Commun 114:1189–1194

    Article  PubMed  CAS  Google Scholar 

  17. Kato Y, Gospodarowicz D (1985) Sulfated proteoglycan synthesis by rabbit costal chondrocytes grown in the presence and absence of fibroblast growth factor. J Cell Biol 100:477–482

    Article  PubMed  CAS  Google Scholar 

  18. Vlodavsky I, Johnson LK, Greenburg G, Gospodarowicz D (1979) Vascular endothelial cells maintained in the absence of fibroblast growth factor undergo structural and functional alterations that are incompatible with their in vivo differentiated properties. J Cell Biol 83:468–486

    Article  PubMed  CAS  Google Scholar 

  19. Gospodarowicz D, Vlodavsky I, Savion N (1981) The role of fibroblast growth factor and the extracellular matrix in the control of proliferation and differentiation of corneal endothelial cells. Vision Res 21:87–103

    Article  PubMed  CAS  Google Scholar 

  20. Montesano R, Vassali JD, Baird A, Guillemin R, Orci L (1986) Basic fibroblast growth factor induces angiogenesis in vitro. Proc Natl Acad Sci USA 83:7297–7301

    Article  PubMed  CAS  Google Scholar 

  21. Slack JMW, Darlington BG, Heath JK, Godsave SF (1987) Heparin binding growth factors as agents of mesoderm induction. Nature 326:197–199

    Article  PubMed  CAS  Google Scholar 

  22. Born J, Davids M, Tiedemann H (1987) Affinity chromatography of embryonic inducing factors on heparin-Sepharose. Cell Diff 21:131–136

    Article  CAS  Google Scholar 

  23. Kimelman D, Kirschner M (1987) Synergistic induction of mesoderm by FGF and TGF-β and the identification of an mRNA coding for FGF in the early Xenopus embryo. Cell 51:869–877

    Article  PubMed  CAS  Google Scholar 

  24. Gospodarowicz D, Mescher AL (1981) Fibroblast growth factor and vertebrate regeneration. Adv Neurol 29:149–171

    PubMed  CAS  Google Scholar 

  25. Gospodarowicz D, Bialecki H, Thakral TK (1979) The angiogenic activity of the fibroblast and epidermal growth factor. Exp Eye Res 28:501–514

    Article  PubMed  CAS  Google Scholar 

  26. Folkman J, Klagsbrun M (1987) Angiogenic factors. Science 235:442–447

    Article  PubMed  CAS  Google Scholar 

  27. Ross R (1986) The pathogenesis of arteriosclerosis: An update. N Engl J Med 314:488–500

    Article  PubMed  CAS  Google Scholar 

  28. Vlodavsky I, Folkman J, Sullivan R, Fridman R, Ishai-Michaeli R, Sasse J, Klagsbrun M (1987) Endothelial cell-derived basic fibroblast growth factor: Synthesis and deposition into subendothelial extracellular matrix. Proc Natl Acad Sci USA 84:2292–2296

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. L. Schweigerer
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Editors and Affiliations

  1. Heidelberger Akademie der Wissenschaften, Karlstraße 4, D-6900, Heidelberg, Deutschland

    Gotthard Schettler (Präsident) (Präsident)

  2. Institut für Biologische Forschung, Gödecke AG, Mooswaldallee 1-9, D-7800, Freiburg, Deutschland

    Dieter Marmé

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© 1988 Springer-Verlag Berlin Heidelberg

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Schweigerer, L. (1988). Basischer Fibroblasten-Wachstumsfaktor: Möglicher Beitrag zur Pathogenese und Therapie der Arteriosklerose. In: Schettler, G., Marmé, D. (eds) Wachstumsfaktoren und Onkogenprodukte bei Entstehung und Regression der Arteriosklerose. Veröffentlichungen aus der Geomedizinischen Forschungsstelle, vol 1988 / 1988/3. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-02553-6_8

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  • DOI: https://doi.org/10.1007/978-3-662-02553-6_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-50286-9

  • Online ISBN: 978-3-662-02553-6

  • eBook Packages: Springer Book Archive

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