Advertisement

Physiological Conditions and Methodological Prerequisits for the In-Vivo Measurement of Substrate Transport in Tumors

  • W. H. Knapp
  • J. M. F. Chamayou
  • H. Ostertag
  • F. Helus
  • S. Matzku
Conference paper

Abstract

During the last decades scintigraphy has emerged to play an essential role in tumor detection and staging. In view of the recent rapid development of newer imaging techniques, it appears useful to reflect on the clinical applicability of the specific potential of scintigraphy.

Keywords

Giant Cell Tumor Substrate Transport Label Substrate Positron Emission Computerize Tomography Local Cerebral Glucose Utilization 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Barcroft H (1974) Circulation in skeletal muscle. In: Hamilton WF, Dow PH (eds) Circulation Vol 11. Baltimore. Williams & Wilkins, pp 1353–1386 (Handbook of Physiology)Google Scholar
  2. 2.
    Beck RE, Schultz IS (1972) Hindrance of solute diffusion within membranes as measured with microporous membranes of known pore geometry. Biochim Biophys Acta 255; 273–303PubMedCrossRefGoogle Scholar
  3. 3.
    Bischoff KB (1975) Some fundamental considerations of the applications of pharacok inetics to cancer chemotherapy. Cancer Chemother Rep 59; 777–793PubMedGoogle Scholar
  4. 4.
    Bolstad. I (1977) Varpro Package. Computer Science Opt. Stanford Univ.Google Scholar
  5. 5.
    Chamayou JMF (1979) Numerical experiments in identification of parameters in differential and partial differential equations. Comput Phys Comm 17; 217–226CrossRefGoogle Scholar
  6. 6.
    Crone C (1963) Permeability of capillaries in cations organs as determined by use of the indicator diffusion method. Acta Physiol Scand 58; 292–305PubMedCrossRefGoogle Scholar
  7. 7.
    Eichling JO,.Raichle ME, Grubb RL Jr., Ter-Pogossain MM (1974) Evidence of the limitations of water as a freshly diffusible tracer in brain in the rhesus monkey. Circulation Res 35; 358–364CrossRefGoogle Scholar
  8. 8.
    Foster DO, Pardee AB (1969) Transport of amino acids by confluent and nonconfuent 3T3 and polyoma virus-transformed 3T3 cells growing an glass cover slips. J Riot Chem 244; 2675–81Google Scholar
  9. 9.
    Getbard AS, Benua RS, Laughlin JS, Rosen G, Reiman RE, McDonaldJM (1979) Quantitative scanning of osteogenic sarcoma with nitrogen-13 labeled L-glutamate. J Nucl Med 20; 782–784Google Scholar
  10. 10.
    Goldstein H, McNeil BJ, Zufall E, Treves S (1980) Is there still a place for bone scanning in Ewing’s sarcoma? J Nucl Med 21: 10–12PubMedGoogle Scholar
  11. 11.
    Golub GH, Pereyra V (1973) The differentiation of pseudo-inverses and non-linear least squares problems whose variables separate. SIAM J Numer Anal 10; 413–432CrossRefGoogle Scholar
  12. 12.
    Hatanaka M (1974) Transport of sugars in tumor membranes. Biochim Biophys Acta (Review on Cancer) 355: 77–104CrossRefGoogle Scholar
  13. 13.
    Hubner KF, King P, Gibbs WD, Partain CL, Washburn LC, Hayes RL, Holloway E (1980) Clinical investigations with “C-labeled amino acids using positron emission computerized tomography in patients with neoplastic diseases. IAEA-SM-247/90Google Scholar
  14. 14.
    Isselbacher KJ (1972) Increased uptake of amino acids and 2-Deoxy-D-Glucose by virus-transformed cells in culture. Proc Natl Acad Sci US 69, 3; 585–589CrossRefGoogle Scholar
  15. 15.
    Knapp WH, Helus F, Ostertag H, Tillmanns H, Kibler W (1982) Uptake and turnover of L) 1N)-Glutamate in the nomial human heart and in patients with coronary artery disease. Eur J Nucl Med 7; 211–215PubMedGoogle Scholar
  16. 16.
    Knapp WH, Helus F, Sinn HJ,Matzku S, Ostertag H, Brandeis WE, Braun A (1983) °N L-glutamate uptake in malignancy. Submitted for publicationGoogle Scholar
  17. 17.
    McKillop JH, Etcubanas E, Coils ML (1981) The indications for and limitations of bone scintigraphy in osteogemic sarcoma: a review of 55 patients. Cancer 48: 1133–1138CrossRefGoogle Scholar
  18. 18.
    Oberdorfer F, Helus F, Maier-Borst W, Silvester DJ (1982) The synthesis of (1-“C) butanol. Radiochem Radioanal Letters 53, 4; 237–252Google Scholar
  19. 19.
    Raichle ME, EichlingJO, Grubb RL Jr (1974) Brain permeability of water. Arch Neurol 30; 319–321PubMedCrossRefGoogle Scholar
  20. 20.
    Raichle ME, Eichling JO, Straatmann MG, Welch MJ, Larson KB, Ter-Pogossian MM (1976) Blood-brain barrier permeability of 11C-labeled alcohols and 11O-labeled water. Am J Physiol 2; 543–552Google Scholar
  21. 21.
    Renkin EM (1959) Transport of potassium-42 from blood to tissue in isolated mammalian skeletal muscles. Am J Physiol 197; 1205–1210PubMedGoogle Scholar
  22. 22.
    Rosen G, Gelbard AS, Benua RS, Laughlin.1, Reiman RE, McDonaldJM (1979) N-13 glutamate scanning to detect the early response of bone tumors to chemotherapy. Proc Am Assoc Cancer Res., March 1979; 189Google Scholar
  23. 23.
    Sejrsen P (1970) Single injection, external registration method for measurement of capillary extraction. In: Crone C, Lassen N (eds) Capillary Permeability, Academic, New York, pp. 256–260Google Scholar
  24. 24.
    Sokoloff L, Reivich M, Kennedy C, DesRosiem Ml-1, Patlak CS, Pettigrew KD, Sakurada D, Shinohara M (1977) The (10C)Deoxyglucose method for the measurement of local cerebral glucose utilization: Theory, procedure, and normal values in the conscious and anesthetized albino rat. J Neurochem 28; 897–916Google Scholar
  25. 25.
    Som P, Atkins HL, Bandoypadhyay D, Fowler 1S, Mac Gregor RR, Matsui K, Oster ZH, Sacker DF, Shiue CY, Tamer H, Wan C-N, Wolf AP, Zabinski SV (1980) A Fluorinated glucose analog, 2-Fluoro-2-deoxy-D-glucose (F-18): Nontoxic tracer for rapid tumor detection. J Nucl Med 21; 670–675Google Scholar
  26. 26.
    Swabb EA, Wei J, Guillino PM (1974) Diffusion and convection in normal and neo-plastic tissues. Cancer Res 34; 2814–2822PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1984

Authors and Affiliations

  • W. H. Knapp
  • J. M. F. Chamayou
  • H. Ostertag
  • F. Helus
  • S. Matzku

There are no affiliations available

Personalised recommendations