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Current Topics in Tumor Cell Physiology and Positron-Emission Tomography pp 37–60Cite as

In Vivo Determination of Kinetic Parameters for Glucose Influx and Efflux by Means of 3-O-11C-Methyl-D-Glucose, 18F-3-Deoxy-3-Fluoro-D-Glucose and Dynamic Positron Emission Tomography; Theory, Method and Normal Values

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Abstract

Imbalance between perfusion, transport and metabolism may determine the ultimate damage in ischemic brain disease (Mies et a1. 1981, Pulsinelli et al. 1981). Therefore, for the quantitative assessment of ischemic brain disorders the. knowledge of at least two parameters is necessary. One is local perfusion. The second parameter should relate to tissue metabolism, for example, to the glucose utilisation rate (Sokoloff et al. 1977, Phelps et al. 1979, Kuhl et a1.1980) or to the local unidirectional glucose transport rate (Vyska et al. 1980, Vyska et al. 1981, Vyska et al. 1982, Vyska et al. 1983, Kloster et al. 1981).

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Authors
  1. K. Vyska
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  2. M. Profant
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  3. F. Schuier
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  4. E. J. Knust
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  5. H.-J. Machulla
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  6. H. M. Mehdorn
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  7. W. H. Knapp
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  8. G. Spohr
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  9. R. von Seggern
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  10. I. Kimmling
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  11. V. Becker
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  12. L. E. Feinendegen
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Editor information

Editors and Affiliations

  1. Inst. f. Nuclear Medicine, German Cancer Res. Center, 6900, Heidelberg, Germany

    Wolfram H. Knapp

  2. Inst. f. Medicine, Nuclear Res. Center, 5170, Jülich, Germany

    Karel Vyska

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© 1984 Springer-Verlag Berlin Heidelberg

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Vyska, K. et al. (1984). In Vivo Determination of Kinetic Parameters for Glucose Influx and Efflux by Means of 3-O-11C-Methyl-D-Glucose, 18F-3-Deoxy-3-Fluoro-D-Glucose and Dynamic Positron Emission Tomography; Theory, Method and Normal Values. In: Knapp, W.H., Vyska, K. (eds) Current Topics in Tumor Cell Physiology and Positron-Emission Tomography. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-02393-8_4

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  • DOI: https://doi.org/10.1007/978-3-662-02393-8_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-13007-9

  • Online ISBN: 978-3-662-02393-8

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