Metabolic and Transport Alterations in Cells Transformed by Rous Sarcoma Virus

Conference paper


When cells become transformed by Rous sarcoma virus, they undergo a number of morphological, metabolic and regulatory alterations which are outlined in Table 1. These changes collectively are often referred to as “the transformed phenotype” and are characteristic, not only of cells transformed in vitro by Rous sarcoma virus (reviewed in Hanafusa 1977) but are often found to occur in cells transformed by many other tumor viruses and by chemical carcinogens as well as in cell cultures derived from spontaneously occuring tumors. The focus of our work has been on analysing the molecular mechanism underlying the increased rate of glucose transport and metabolism in cells transformed by Rous sarcoma virus. This biological phenomenon was first described by Hatanaka and his colleagues (1970).


Rous Sarcoma Virus Chicken Embryo Fibroblast Hexose Transport Increase Glucose Transport Hexose Uptake 
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© Springer-Verlag Berlin Heidelberg 1984

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