Pharmacotoxicology of High-Dose Thiotepa

  • Gilles Vassal
  • Olivier Hartmann
Conference paper
Part of the ESO European School of Oncology Monographs book series (ESO MONOGRAPHS)


Thiotepa is an alkylating agent that was first synthesised in the 1950s. It can be administered intravenously, intravesically and intrathecally. At conventional doses the main adverse effect is haematopoietic toxicity. For about 10 years now thiotepa has been used at high doses prior to bone marrow transplantation. High-dose thiotepa has been particularly developed in the USA, while high-dose melphalan is preferred in Europe.


Bone Marrow Transplantation Conventional Dose Autologous Bone Marrow Transplantation Main Adverse Effect Bone Marrow Rescue 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • Gilles Vassal
    • 1
  • Olivier Hartmann
    • 1
  1. 1.Paediatric DepartmentInstitut Gustave-RoussyVillejuifFrance

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