Pharmacotoxicology of High-Dose Thiotepa
Thiotepa is an alkylating agent that was first synthesised in the 1950s. It can be administered intravenously, intravesically and intrathecally. At conventional doses the main adverse effect is haematopoietic toxicity. For about 10 years now thiotepa has been used at high doses prior to bone marrow transplantation. High-dose thiotepa has been particularly developed in the USA, while high-dose melphalan is preferred in Europe.
KeywordsToxicity Oncol Melphalan Neutropenia Cyclophosphamide
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