Transmembrane APP is Distributed into Two Pools and Associated with Polymerized Cytoskeleton
βA4 peptide is the major component of extracellular amyloid deposits present in the brain of patients with Alzheimer’s disease. The sequence of βA4 indicates that it is cleaved from the larger amyloid precursor protein (APP). APP is encoded by a single gene which yields, by alternative splicing, three major isoforms designated APP770, APP751, APP695. Sequence analysis suggests that APP is a transmembrane protein having a long N-terminal extracellular domain, a transmembrane region and a short cytoplasmic tail (Kang et al. 1987).
KeywordsParaformaldehyde Glycosaminoglycan A23187 Eisen Mellon
Unable to display preview. Download preview PDF.
- Seubert P, Vigo-Pelfrey C, Esch F, Lee M, Dovey H, Davis D, Sinha S, Schlossmacher M, Whaley J, Swindlehurst C, McCormack R, Wolfert R, Selkoe D, Lieberburg I, Schenk D (1992) Isolation and quantification of soluble Alzheimer’s β-peptide from biological fluids. Nature 359: 325–327PubMedCrossRefGoogle Scholar