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HPLC with Thermospray Mass Spectrometry

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Book cover Analysis of Pesticides in Ground and Surface Water II

Part of the book series: Chemistry of Plant Protection ((PLANT PROTECTIO,volume 12))

Abstract

On-line coupling HPLC — MS via a thermospray interface is the preferred alternative among HPLC — MS ionization techniques for pesticide trace analysis of (aquatic) environmental samples. After a discussion of the theoretical principles for ionization of molecules capable of producing suitable signals, many of the factors influencing instrumental performance are explained. Referring to reports from the literature, but mostly by means of our experience with experimental methods, nearly 150 pesticides are dealt with. By optimization of the parameters which affect the sensitivity and the specifity the best results for most of the various pesticides may be achieved, so that the legislative demands for water protection can be fulfilled. The special value of the HPLC — MS technique lies in the field of structural information and confirmation. Here tandem MS technique, postcolumn addition of additives, enhanced positive and negative ion generation among others may be useful for application down to the sub-nanogram per liter level.

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Author information

Authors and Affiliations

  1. US Food and Drug Administration, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, Arkansas, 72079, USA

    Dietrich Volmer

  2. Fraunhofer Institut für Toxikologie und Aerosolforschung, Nikolai-Fuchs-Straße 1, D-30625, Hannover, Germany

    Karsten Levsen

Authors
  1. Dietrich Volmer
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  2. Karsten Levsen
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Editor information

Editors and Affiliations

  1. Technische Universität Berlin, Gustav-Meyer-Allee 25, D-13355, Berlin, Germany

    H.-J. Stan

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© 1995 Springer-Verlag Berlin Heidelberg

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Volmer, D., Levsen, K. (1995). HPLC with Thermospray Mass Spectrometry. In: Stan, HJ. (eds) Analysis of Pesticides in Ground and Surface Water II. Chemistry of Plant Protection, vol 12. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-01063-1_6

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  • DOI: https://doi.org/10.1007/978-3-662-01063-1_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-01065-5

  • Online ISBN: 978-3-662-01063-1

  • eBook Packages: Springer Book Archive

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