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History of the Development of Thin-Layer Chromatography

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Abstract

It is remarkable that although the principle of thin-layer chromatography was described as early as 25 years ago, this method has become accepted as indispensable only during the last 3 years. A short summary of the development of thin-layer chromatography is, therefore, not only interesting in itself, but also will help towards an understanding of the technique. The first publication in the field dates back to the period when Tswett’s column chromatography was enjoying a great success. It was at this time that constant efforts were being made to achieve “micro-chromatography” by reducing the diameter of the column to 1 mm. The inherent difficulties were summed up by Zechmeister [74] in 1938 as follows: “The main problem in ‘micro-chromatography’ is not the development of the right apparatus (i.e. for column chromatography), but the accurate identification of adsorbed substances.” This problem was solved by the change-over from the “closed” to the “open” column, to the thin separating layer, in fact. This method, published some years ago, demonstrated the simplicity of the process and its wide applicability [56].

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Bibliography to Chapters A – D: General Section

  1. Applewhite, T. H., M. J. Diamond and L. A. Goldblatt: J. Am. Oil Chem. Soc. 38, 609 (1961).

    Article  CAS  Google Scholar 

  2. Baehler, B.: Schweiz. Apotheker-Ztg. 99, 543 (1961).

    CAS  Google Scholar 

  3. Barbier, M., H. Jäger, H. Tobias and E. Wyss: Heiv. Chim. Acta 42, 2440 (1959).

    Article  CAS  Google Scholar 

  4. Birkofer, L., CH. Kaiser, H.-A. Meyer-Stoll and F. Suppan: Z. Naturforsch. 17b, 352 (1962).

    Google Scholar 

  5. Bolliger, A., and J. E. Bolliger: The Royal Australian Chemical Institute Proc. Feb. 1962, S. 78.

    Google Scholar 

  6. Brenner, M., and A. Niederwieser: Experientia (Basel) 17, 237 (1961).

    Article  CAS  Google Scholar 

  7. Brenner, M., A. Niederwieser, G. Pataki and A. R. Fahmy: Experientia (Basel) 18, 101 (1962).

    Article  CAS  Google Scholar 

  8. Consden, R., A. H. Gordon and A.J. P. Martin: Biochem. J. 38, 224 (1944).

    CAS  Google Scholar 

  9. Crowe, M. O’L.: Anal. Chem. 13, 845 (1941).

    CAS  Google Scholar 

  10. Davidek, J., and E. Davidkova: Pharmazie 16, 352 (1961).

    Google Scholar 

  11. Davidek, J., Z. Prochazka: Collection Czechoslov. Chem. Commun. 26, 2947 (1961).

    CAS  Google Scholar 

  12. Demole, E.: J. Chromatogr. 6, 2 (1961).

    Article  CAS  Google Scholar 

  13. Egger, K.: Z. analyt. Chem. 182, 161 (1961).

    Article  CAS  Google Scholar 

  14. Goppelsroeder, F.: Anregungen zum Studium der auf Capillaritäts-und Adsorptionserscheinungen beruhenden Capillaranalyse. Basel: Verlag Helbing und Lichtenhahn, 1906.

    Google Scholar 

  15. Hais, I M, and K Macer: Handbuch der Papierchromatographie. Jena: VEB Fischer Verlag 1958/1960. Engl. Ed. New York: Academic Press, Inc. 1964.

    Google Scholar 

  16. Halpaap, H.: Private communication.

    Google Scholar 

  17. Hausser, H.: Mitt.-B1. Ges. Dtsch. Chem. Lebensmittelchem. gerichtl. Chem. 13, 194 (1959).

    Google Scholar 

  18. Hesse, G. and M. Alexander: Abstract, sJournée internationale d’Étude des Méthodes de séparation immédiate et de Chromatographie», 13., 14., 15. June 1961. Paris.

    Google Scholar 

  19. Honegger, C. G.: Rely. Chim. Acta 44, 173 (1961).

    Article  CAS  Google Scholar 

  20. Izmailov, N. A., and M. S. Shraiber: Farmazia 3, 1 (1938).

    Google Scholar 

  21. Jensen, A.: Tidsskr. Kjemi, Bergvesen Met. 1, 14 (1961).

    Google Scholar 

  22. Kaufmann, H. P., and Z. Makus: Fette, Seifen, Anstrichmittel 62, 1014 (1960).

    Article  CAS  Google Scholar 

  23. Kaufmann, H. P., Z. Makus and T. H. Kiioe: Fette, Seifen, Anstrichmittel 63, 689, 807, 828 (1961).

    Article  Google Scholar 

  24. Kaufmann, H. P., and T. H. Khoe: Fette, Seifen, Anstrichmittel 64, 81 (1962).

    Article  CAS  Google Scholar 

  25. Kirchner, J. G., and G. I. Keller: J. Am. Chem. Soc. 72, 1867 (1950).

    Article  CAS  Google Scholar 

  26. Kirchner, J. G., J. M. Miller and G. I. Keller: Anal. Chem. 23, 420 (1951).

    Article  CAS  Google Scholar 

  27. Lagoni, H., and A. Wortmann: Milchwissenschaft 10, 360 (1955).

    CAS  Google Scholar 

  28. Lagoni, H., and A. Wortmann: Milchwissenschaft 11, 206 (1956).

    Google Scholar 

  29. Machata, G: Mikrochim. Acta, 1960, 79.

    Google Scholar 

  30. Mangold, H. K.: Fette, Seifen, Anstrichmittel 61, 877 (1959).

    Article  CAS  Google Scholar 

  31. Mangold, H. K.: J. Am. Oil Chemists Soc. 38, 708 (1961).

    Article  CAS  Google Scholar 

  32. Martin, A. J. P., and R. L. M. Synge: Biochem. J. 35, 91, 1358 (1941).

    CAS  Google Scholar 

  33. Matthias, W.: Naturwissenschaften 41, 18 (1954).

    Article  Google Scholar 

  34. Meinhard, J. E., and N. F. Hall: Anal. Chem. 21, 185 (1949).

    Article  CAS  Google Scholar 

  35. Meyer, H.: Deut. Lebensm.-Rundschau 7, 170 (1961).

    Google Scholar 

  36. Miller, J M and J. G. Kirchner: Anal. Chem. 24, 1480 (1952).

    Article  CAS  Google Scholar 

  37. Miller, J M and J. G. Kirchner: Anal. Chem. 25, 1107 (1953).

    Article  CAS  Google Scholar 

  38. Miller, J. M., and J. G. Kirchner: Anal. Chem. 26, 2002 (1954).

    Google Scholar 

  39. Mistryukov, E. A.: Collection Czechoslov. Chem. Commun. 26, 2071 (1961).

    CAS  Google Scholar 

  40. Mottier, M.: Mitt. Gebiete Lebensm. and Hyg. 47, 372 (1956).

    CAS  Google Scholar 

  41. Mottier, M.: Mitt. Gebiete Lebensm. and Hyg. 49, 453 (1958).

    Google Scholar 

  42. Neubern de Toledo, T. A., R. Wasicky: Correio do Mundo Farmaceutico (Brasilien) v. 15. Juli 1961.

    Google Scholar 

  43. Pastuska, G., and H. Trinks: Chemiker-Ztg. 85, 535 (1961).

    Google Scholar 

  44. Pastuska, G., and H. Trinks: Chemiker-Ztg. 86, 135 (1962).

    CAS  Google Scholar 

  45. Peereboom, J. W. C.: Chem. Weekblad 49, 625 (1961).

    Google Scholar 

  46. Prochazka, Z.: Chem. Listy 55, 974 (1961).

    CAS  Google Scholar 

  47. Randerath, K.: Angew. Chem. 73, 436 (1961).

    Article  CAS  Google Scholar 

  48. Randerath, K.: J. Chromatogr. 6, 365 (1961).

    Article  CAS  Google Scholar 

  49. Reindel, F., and W. Hoppe: Naturwissenschaften 40, 245 (1953).

    Article  CAS  Google Scholar 

  50. Reitsema, R. H.: J. Am. Pharm. Assoc. 43, 414 (1954).

    CAS  Google Scholar 

  51. Reitsema, R. H.: Anal. Chem. 26, 960 (1954).

    Article  CAS  Google Scholar 

  52. Ritter, F. J., and G. M. Meyer: Nature (Lond.) 193, 941 (1962).

    Article  CAS  Google Scholar 

  53. RSCO Review 3, 18 (1961).

    Google Scholar 

  54. Schorn, P. J.: Glas-Instr.-Tech. 5, 43 (1961).

    CAS  Google Scholar 

  55. Stahl, E.: Pharmazie 11, 633 (1956).

    CAS  Google Scholar 

  56. Stahl, E.: Chemiker.-Ztg. 82, 323 (1958).

    CAS  Google Scholar 

  57. Stahl, E.: Parfümerie and Kosmetik 39, 564 (1958).

    Google Scholar 

  58. Stahl, E.: Arch. Pharmaz. 292, 411 (1959).

    Article  CAS  Google Scholar 

  59. Stahl, E.: Pharmaz. Rundsch. 1, Nr. 2, 1 (1959).

    Google Scholar 

  60. Stahl, E.: Arch. Pharmaz. 293, 531 (1960).

    Article  CAS  Google Scholar 

  61. Stahl, E.: Z. analyt. Chem. 181, 303 (1961).

    Article  CAS  Google Scholar 

  62. Stahl, E.: Angew. Chem. 73, 646 (1961).

    Article  CAS  Google Scholar 

  63. Stahl, E.: Unpublished.

    Google Scholar 

  64. Stahl, E., and U. Kaltenbach: J. Chromatogr. 5, 458 (1961).

    Article  CAS  Google Scholar 

  65. Stanley, W. L., S. H. Vannier and B. Gentili: J. Assoc. Offic. Agr. Chemists 40, 282 (1957).

    CAS  Google Scholar 

  66. Stanley, W. L., and S. H. Vannier: J. Assoc. Offic. Agr. Chemists 40, 582 (1957).

    CAS  Google Scholar 

  67. Teijgeler, C. A.: Pharmac. Weekblad 97, 43 (1962).

    CAS  Google Scholar 

  68. Umland, F., and K. Kirchner: Z. anorg. Chem. 280, 211 (1955).

    Article  CAS  Google Scholar 

  69. Wagner, H.: Mitt. Gebiete Lebensm. and Hyg. 51, 416 (1960).

    CAS  Google Scholar 

  70. Williams, T. I.: Introduction to Chromatography. Glasgow: Blackie Son 1947.

    Google Scholar 

  71. Winterstein, A., A. Studer and R. Ruegg: Chem. Ber. 93, 2951 (1960).

    Article  CAS  Google Scholar 

  72. Woelm, M.: Mitteilungen AL 10 (1961).

    Google Scholar 

  73. Wollisi, E. G., M. Schmall and M. Hawrylyshyn: Anal. Chem. 33, 1138 (1961).

    Article  Google Scholar 

  74. Zechmeister, L., and L. Cholnoky: Die chromatographische Adsorptionsanalyse. 2. Aufl. Wien: Springer Verlag 1938.

    Book  Google Scholar 

Some recent noteworthy articles

  • Bekersky, I.: Anal. Chem. 35, 261 (1963): Spray technique for the preparation of TLC-plates.

    Google Scholar 

  • Brodasky, T. F.: Anal. Chem. 35, 343 (1963): Carbon layers, microbiological detection of antibiotics.

    Google Scholar 

  • Cerri, O., and G. Maffi: Boll. Chim. Parmac. 100, 940 (1961): Review article.

    Google Scholar 

  • Duncan, G. R.: J. Chromatog. 8, 37 (1962): TLC-spreader.

    Google Scholar 

  • Feltkamp, H.: Dtsch. Apoth. Ztg. 102, 1269 (1962): TLC on a glass rod.

    Google Scholar 

  • Gamp, A., P. Studer, H. Linde and K. Meyer: Experientia 18, 292 (1962): TLC on grooved plates.

    Google Scholar 

  • Halpaap, H.: Chem. Ing. Techn. 35, 488 (1963): Preparative TLC.

    Google Scholar 

  • Hörhammer, L., H. Wagner and G. Bittner: Dtsch. Apotheker 14/4, 1 (1962): Manually prepared TLC-plates.

    Google Scholar 

  • Honegger, C. G.: Heiv. Chim. Acta 46, 1772 (1963): Preparative TLC.

    Google Scholar 

  • Hüttenrauch, R., L. Klotz and W. Müller: Z. Chem. 3, 193 (1963): Layers of ion-exchange resins.

    Google Scholar 

  • Kelemen, J., and G. Pataki: Z. analyt. Chem. 195, 81 (1963): Differences between layers prepared manually and by the standard method.

    Google Scholar 

  • Kokoti-Kotakis, E.: Chim. Chronika (Athens) 27 A, 59 (1962): Review article.

    Google Scholar 

  • Lie, K. B., and J. F. Nyc: J. Chromatog. 8, 75 (1962): TLC in test tubes.

    Google Scholar 

  • Lüdy-Tenger, F.: Pharmac. Acta Rely. 37, 770 (1962): Review article; spreader.

    Google Scholar 

  • Malins, D. C., and J. C. Wekell: J Chem. Educ. 40, 531 (1963): Review article.

    Google Scholar 

  • Morgan, M. E.: J. Chromatog. 9, 379 (1962): Apparatus for simultaneous application of several spots.

    Google Scholar 

  • Morita, K., and F. Haruta: J. Chromatog. 12, 412 (1963): Spraying method for the preparation of TLC-plates.

    Google Scholar 

  • Munter, F.: Chemiker Ztg. 87, 657 (1963): Choice of eluents.

    Google Scholar 

  • Pataki, G., and J. Kelemen: J. Chromatog. 11, 50 (1963): Differences between layers prepared manually and by the standard method.

    Google Scholar 

  • Peifer, J. J.: Mikrochim. Acta 1962, 529: Microchromatoplates.

    Google Scholar 

  • Rusiecki, W., and M. Henneberg: Farmacja Polska 18, 203 (1962): Review article.

    Google Scholar 

  • Russel, J. H.: Rev. Pure Appl. Chem. 13, 15 (1962): Review article.

    Google Scholar 

  • Seher, A.: J. Soc. Cosm. Chem. 13, 385 (1962): Review article.

    Google Scholar 

  • Shellard, E. J.: Research and Development No. 21, 30 (1963): Review article.

    Google Scholar 

  • Srepel, B.: Farmac. Glasnik (Zagreb) 18, 64 (1962): Review article.

    Google Scholar 

  • Stahl, E.: Development and application of TLC, 11th commun., review article, Sei. Reports Istituto Superiore di Sanita, Roma, Elsevier Publ. Comp. Amsterdam, in press.

    Google Scholar 

  • Waldi, D.: Arch. Pharmaz. 296, Mitteilungen 1 (1963): Review article.

    Google Scholar 

  • Waldi, D.: Glas Instrumenten Technik 7, 477 (1963): Review article: adsorbents.

    Google Scholar 

Books

  • Bobbitt, J. M.: Thin-Layer Chromatography, Reinhold Publishing Corp., New York/London 1963.

    Google Scholar 

  • Randerath, K.: Thin-Layer Chromatography (Engl. Edit.) Verlag Chemie, Weinheim 1963; ( German Edit.: Dünnschicht-Chromatographie 1962 ).

    Google Scholar 

  • Stahl, E.: Dünnschicht-Chromatographie, Ein Laboratoriumshandbuch, Springer, Berlin-Göttingen-Heidelberg 1962.

    Google Scholar 

  • Truter, E. V.: Thin Film Chromatography, Cleaver-Hume Press, London 1963.

    Google Scholar 

Films

  • Ahrens, E. H.: TLC, ca. 20 min, colored with sound, 16 mm, The Rockefeller Institute, New York, U.S.A. 1963.

    Google Scholar 

  • Privett, O. S.: TLC, ca. 45 min, colored with sound, 16 mm, The Hormel Institute, Austin, Minn., U.S.A. 1963.

    Google Scholar 

  • Seiler, H.: Short motion picture, ca. 10 min, Institut für Anorganische Chemie der Universität Basel, Switzerland.

    Google Scholar 

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Stahl, E. (1965). History of the Development of Thin-Layer Chromatography. In: Stahl, E. (eds) Thin-Layer Chromatography. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-01031-0_1

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