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Cellular Mechanisms of Spontaneous Hypertension and Stroke: Role of Vascular Smooth Muscle Cells

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Cellular Aspects of Hypertension

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Abstract

The development of rat models for hypertension and stroke has enabled us to study cellular mechanisms of spontaneous hypertension and stroke experimentally and to extend our investigation into the pathogenesis of these diseases in humans from cellular aspects. This paper will first review the development of rat models of various cardiovascular diseases and their genetic background, then describe the characteristics of cultured vascular smooth muscle cells (VSMC) from rat models for hypertension and stroke, and finally report on our experimental studies on stroke as well as pathological studies in humans, seeking analogies between rat models and humans in the cellular aspects of stroke, the most prevalent complication of hypertension.

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Author information

Authors and Affiliations

  1. Department of Pathology, Shimane Medical University, Izumo 693, Japan

    Y. Yamori, Y. Nara & R. Horie

  2. Department of Laboratory Medicine, Shimane Medical University, Izumo 693, Japan

    T. Nabika

  3. Department of Internal Medicine, Sanraku Hospital, Tokyo 101, Japan

    M. Tagami

Authors
  1. Y. Yamori
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  2. Y. Nara
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  3. T. Nabika
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  4. M. Tagami
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  5. R. Horie
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Editors and Affiliations

  1. Istituto di Clinica Medica e Nefrologia, Facolta di Medicina e Chirurgia, Università degli Studi di Parma, Via A. Gramsci, 14, I-43100, Parma, Italy

    Giacomo Bruschi  & Alberico Borghetti  & 

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© 1991 Springer-Verlag Berlin • Heidelberg

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Yamori, Y., Nara, Y., Nabika, T., Tagami, M., Horie, R. (1991). Cellular Mechanisms of Spontaneous Hypertension and Stroke: Role of Vascular Smooth Muscle Cells. In: Bruschi, G., Borghetti, A. (eds) Cellular Aspects of Hypertension. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-00983-3_3

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  • DOI: https://doi.org/10.1007/978-3-662-00983-3_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-00985-7

  • Online ISBN: 978-3-662-00983-3

  • eBook Packages: Springer Book Archive

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