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Regulation of the Na+/H+ Exchanger in Essential Hypertension: Functional and Genetic Abnormalities

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Cellular Aspects of Hypertension

Abstract

Ten years ago, we initiated studies of the genetic variations of Na+ transport systems as an approach to the genetics of hypertension. One of these biochemical phenotypes, Na+/Li+ exchange (Na/Li EXC), is elevated in a sizable proportion of the essentially hypertensive population. Furthermore, the abnormalities observed have been shown by family studies to be largely genetically determined [1,2,3]. In pursuing the question of what significance these abnormalities might have in the pathophysiology of hypertension, we found that Na+/Li+ countertransport has many features in common with the Na+/H+ exchanges (Na/H EXC). The Na+ exchanges system is expressed not only in red blood cells (rbc), but in three target tissues of the hypertensive process: vascular smooth muscle (VSM) [4,5], kidney epithelial [6] and adrenal glomerulosa cells [7]. In these cells Na/H EXC regulates cell pH and volume, and it is modulated by vasocontrictor and growth factor agonist which mobilize Ca2+ [4,8,10].

Supported by grants from the National Institute of Health, NHLBI 35664 and by a specialized Center of Research Award in Hypertension (1P50HP-36568).

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Authors and Affiliations

  1. Endocrinology-Hypertension Division, Laboratory of Cellular Transport, Brigham and Women’s Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, MA, 02115, USA

    M. Canessa

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  1. M. Canessa
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  1. Istituto di Clinica Medica e Nefrologia, Facolta di Medicina e Chirurgia, Università degli Studi di Parma, Via A. Gramsci, 14, I-43100, Parma, Italy

    Giacomo Bruschi  & Alberico Borghetti  & 

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Canessa, M. (1991). Regulation of the Na+/H+ Exchanger in Essential Hypertension: Functional and Genetic Abnormalities. In: Bruschi, G., Borghetti, A. (eds) Cellular Aspects of Hypertension. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-00983-3_18

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  • DOI: https://doi.org/10.1007/978-3-662-00983-3_18

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-00985-7

  • Online ISBN: 978-3-662-00983-3

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