Abstract
Investigation of the mode of inheritance of systolic blood pressure as a quantitative trait in families and its distribution in the population has led to two main conclusions: (1) blood pressure is under genetic control and 30%–40% of its variability is determined by the variance in the qenome; (2) there is no single major gene responsible for the variation of blood pressure in a population [1,2]. The variety of clinical forms of primary hypertension suggests a heterogeneity of the disease [3]. This heterogeneity complicates the identification of hereditary factors determining the variability of blood pressure in humans.
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© 1991 Springer-Verlag Berlin • Heidelberg
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Kotelevtsev, Y.V., Postnov, Y.V. (1991). RFLP Study of the SHR Genome in Relation to Cell Membrane Abnormalities. In: Bruschi, G., Borghetti, A. (eds) Cellular Aspects of Hypertension. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-00983-3_17
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DOI: https://doi.org/10.1007/978-3-662-00983-3_17
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