RFLP Study of the SHR Genome in Relation to Cell Membrane Abnormalities

  • Y. V. Kotelevtsev
  • Y. V. Postnov
Conference paper


Investigation of the mode of inheritance of systolic blood pressure as a quantitative trait in families and its distribution in the population has led to two main conclusions: (1) blood pressure is under genetic control and 30%–40% of its variability is determined by the variance in the qenome; (2) there is no single major gene responsible for the variation of blood pressure in a population [1,2]. The variety of clinical forms of primary hypertension suggests a heterogeneity of the disease [3]. This heterogeneity complicates the identification of hereditary factors determining the variability of blood pressure in humans.


Quantitative Trait Locus Restriction Fragment Length Polymorphism Intermediate Phenotype Primary Hypertension Recombinant Inbred Strain 
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Copyright information

© Springer-Verlag Berlin • Heidelberg 1991

Authors and Affiliations

  • Y. V. Kotelevtsev
    • 1
  • Y. V. Postnov
    • 1
  1. 1.Central Research LaboratoryMinistry of Public Health of the USSRMoscowUSSR

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