Die Gestagene pp 805-924 | Cite as

Die Anwendung der Gestagene in Veterinärmedizin und Zootechnik

  • W. Jöchle
Part of the Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology book series (HEP, volume 22 / 2)

Zusammenfassung

In der Veterinärmedizin sind Gestagene überall dort anwendbar,
  1. 1.

    wo ein absolutes oder relatives Gestagendefizit die gewünschte Fortpflanzungsfunktion in Frage stellt (Substitutionstherapie);

     
  2. 2.

    wo ruhende, partiell insuffiziente oder unterschwellige Sexualfunktionen durch die positive Feedback-Wirkung kleiner Gestagendosen am hypothalamohypophysären Sexualzentrum stimuliert werden können;

     
  3. 3.

    wo Impulsunterbrechungen, d. h. temporäre zentrale Ruhigstellung mit höher dosierten Gestagenen — durch negative Feedback-Wirkungen — entgleist gewesene Funktionskreise erfahrungsgemäß wieder einzuregeln vermögen. Dabei unterstützt die mit dem Abklingen der Gestagenwirkung wieder positiv werdende Feedback-Aktion das Wieder-Ingangkommen regelgerechter Fortpflanzungsfunktionen, wobei mit Hilfe des „Rebound-Phänomens“ höhere Leistungen der Fortpflanzungsfunktionen (sowohl germinativer wie neuroendokriner Art) erzielt werden können [56, 70].

     

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