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Besonderheiten der Wirkungen der einzelnen Gestagene auf Morphologie und Funktion des Genitaltraktes

  • Ch. Lauritzen
  • W.-D. Lehmann
  • W. Elger
  • R. R. Salloch
  • J. D. Hahn
  • F. Neumann
  • H. Steinbeck
  • F. Neumann
  • H.-J. Merker
Part of the Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology book series (HEP, volume 22 / 2)

Zusammenfassung

Das natürliche gestagene Hormon Progesteron ist für die therapeutische Anwendung beim Menschen nur mit Einschränkung geeignet. Es ist oral verabfolgt praktisch unwirksam. Da Progesteron in den üblichen Medien nicht sehr gut löslich und im Gewebe lokal ziemlich schlecht verträglich ist, kann es parenteral nicht immer in den erwünschten hohen Konzentrationen injiziert werden. Auf Grund der beiden Oxogruppen des Progesteron an C-3 und C-20 war eine Protraktion durch Veresterung mit den gebräuchlichen Verfahren nicht möglich und daher die Belästigung durch häufige Injektionen nicht zu umgehen. Auch die sehr kurze Halbwertszeit des Progesteron und seine rasche Verstoffwechslung zu unwirksamen Metaboliten schränkt die Verwendbarkeit des Hormons in der Therapie stark ein. Schließlich liegt es in dem physiologischen Wirkungsbild des Progesteron begründet, daß das Hormon eine vergleichsweise schwache blutungsauslösende, blutungsstillende und ovulationshemmende Wirkung besitzt.

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