Abstract
Much attention has been paid to only natural antibody titer of the recipients in ABO-incompatible kidney transplantation. In this study, we looked at the distribution of blood type antigens in the kidney tissue. Thirty-seven biopsy specimens from patients with nephritis or transplanted kidneys were recruited. Fifteen were type A, 14 were type B, and 8 were type AB. Kidney tissues were stained with anti-A or anti-B antibody using immunohistological staining. The stained dots in each section were regarded as the area and were measured by image analyzer. B antigen was expressed very weakly both in the glomeruli and in interstitium as compared with A antigen. In type AB, B antigen was less expressed than A antigen. Based on these results, we performed B-incompatible kidney transplantation. No rejection was seen without preoperative depletion of natural antibody and splenectomy. These results may suggest that type B-incompatible kidney transplantation might possibly be performed without preoperative depletion of natural antibodies.
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© 1996 Springer-Verlag Berlin Heidelberg
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Koyama, I., Taguchi, Y., Sugahara, S., Akimoto, N., Omoto, R. (1996). Weak expression of blood type B antigen in kidney tissue and successful B-incompatible kidney transplantation without special treatments. In: Mühlbacher, F., et al. Transplant International . Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-00818-8_7
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DOI: https://doi.org/10.1007/978-3-662-00818-8_7
Publisher Name: Springer, Berlin, Heidelberg
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