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Short-term outcome of kidney transplants from non-heart-beating donors after preservation by machine perfusion

  • J. H. C. Daemen
  • R. J. de Wit
  • M. W. G. A. Bronkhorst
  • M. L. Marcar
  • M. Yin
  • E. Heineman
  • G. Kootstra
Conference paper

Abstract

In this study, the short-term outcome of renal transplants from non-heart-beating donors (NHBD) preserved by machine perfusion (MP) is evaluated and compared to preservation by cold storage (CS). Twenty-two NHBD kidneys were procured during 1993 and 1994 after in situ perfusion with histidine-tryptophan ketoglutarate and preserved by continuous perfusion using University of Wisconsin organ preservation solution for MP as a perfusate. Between 1980 and 1992, 57 NHBD kidneys were procured and preserved by CS. Donors in the MP group sustained increased first warm ischemia times (WIT1) (P < 0.1) and recipients in the MP group suffered longer anastomosis time, worse HLA-DR mismatch,and more initial use of cyclosporin as immunosuppressant; all these factors are known to be deleterious to short-term outcome. Despite these unfavorable conditions, delayed function (DF) rate was decreased in the MP group, although not significantly. However, when considering only kidneys with WIT1 ≥ 45 min, short-term outcome was significantly better in the MP group (P < 0.05). We conclude that MP is superior for the preser-vation of NHBD kidneys, especially after prolonged warm ischemia.

Key words

Non-heart-beating donors Kidney transplantation Short-term outcome Machine perfusion Delayed graft function 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • J. H. C. Daemen
    • 1
  • R. J. de Wit
    • 1
  • M. W. G. A. Bronkhorst
    • 1
  • M. L. Marcar
    • 1
  • M. Yin
    • 1
  • E. Heineman
    • 1
  • G. Kootstra
    • 1
  1. 1.Department of SurgeryUniversity Hospital MaastrichtMaastrichtThe Netherlands

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