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A critical analysis of soluble interleukin-2 receptor levels in kidney allograft recipients

  • Conference paper
Transplant International

  • 62 Accesses

Abstract

Soluble interleukin-2 receptor (sIL-2R) was measured by the Cellfree Kit (T Cell sciences) in 103 pretransplant and 1590 post-transplant samples from 103 patients with cadaveric kidney allografts. The mean values (± SD) detected in pretransplant sera were significantly higher (1932 ± 1389 U/ml) than in 72 healthy adults (267 ± 139 U/ml), but after transplantation they continuously fell towards normal levels within the first 3 postoperative weeks. Recipients with acute rejection episodes showed higher sIL-2R levels (1762 ± 904 U/ml) than those with stable transplants at discharge (937 ± 398 U/ml). Highest values were detected during antirejection therapy with antithymocyte globulin (4996 ± 2166 U/ml) or OKT3 (5905 ± 3910). Increases were also observed during bacterial and viral infections and even, in some cases, without any apparent cause. Because of this lack of specificity, elevated sIL-2R levels should be interpreted cautiously. Nevertheless, sIL-2R level can be useful for monitoring kidney allograft recipients. Increases point to a cellular immune activation process and can predict rejections or infections.

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Author information

Authors and Affiliations

  1. Department of Laboratory Medicine, Friedrichshain Hospital, Landsberger Allee 49, D-10249, Berlin, Germany

    J. Kaden

  2. DPC Biermann GmbH, Hohe Strasse 2-4, D-61231, Bad Nauheim, Germany

    B. Schütze

  3. Kidney Transplant Centre, Friedrichshain Hospital, Landsberger Allee 49, D-10249, Berlin, Germany

    G. May

Authors
  1. J. Kaden
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  2. B. Schütze
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  3. G. May
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Editor information

Editors and Affiliations

  1. Vienna, Austria

    Ferdinand Mühlbacher

  2. Department of Surgery, University Hospital, P.Debyelaan 25, P.O. Box 5800, 6202 AZ, Maastricht, The Netherlands

    G. Kootstra

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© 1996 Springer-Verlag Berlin Heidelberg

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Kaden, J., Schütze, B., May, G. (1996). A critical analysis of soluble interleukin-2 receptor levels in kidney allograft recipients. In: Mühlbacher, F., et al. Transplant International . Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-00818-8_17

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  • DOI: https://doi.org/10.1007/978-3-662-00818-8_17

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-61024-3

  • Online ISBN: 978-3-662-00818-8

  • eBook Packages: Springer Book Archive

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