Advertisement

Hochdruck und Mikrozirkulation

  • E. Volger

Zusammenfassung

Die Pathophysiologie des Hochdrucks ist ohne Kenntnisse der Vorgänge in der Mikrozirkulation nicht zu verstehen. Die Mikrozirkulation stellt eine Funktionseinheit aus den terminalen Gefäßen mit einem Durchmesser unter 300 μm, den komplexen Strömungsvorgängen in diesem Gebiet des Kreislaufes und den Austauschvorgängen von Blutbestandteilen mit dem Gewebe in den Kapillaren und Venulen dar. Die Perfusion wird durch den Tonus der Arteriolen, der präkapillären Sphinkteren und der Venulen reguliert, durch die komplexen Fließeigenschaften des Blutes modifiziert.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. 1.
    Becker RA (1980) Hypertension and arteriosclerosis in clinical ophthalmology (Vol.3, Chap. 13 ). Harper and Row, HagerstownGoogle Scholar
  2. 2.
    Bevan RA, Bevan RD, Duckles SP (1980) Adrenergic regulation of vascular smooth muscle. In: Bohr, Somlyo, Sparks (eds) Handbook of physiology (Sect 2, Vol II ). Amer Physiolog Soc Bethesda, p 515–566Google Scholar
  3. 3.
    Bollinger A, Butti P, Barras JP, Trachsler H, Siegenthaler W (1974) Red blood cell velocity of man. Measurements by a television microscopic technique. Microvasc Res 7: 61Google Scholar
  4. 4.
    Brunstock G (1980) Cholinergic and purinergic regulation of blood vessels. In: Bohr, Somlyo, Sparks (eds) Handbook of physiology (Sect 2, Vol II ). Amer Physiol Soc Bethesda, p 267–612Google Scholar
  5. 5.
    Dermietzel R, Eichner R (1979) Ultrastructure of cerebral capillaries in normotensive spontaneous hypertensive and acute hypertensive rats. Bibl Anat 18: 174–176PubMedGoogle Scholar
  6. 6.
    Dintenfass L, Bauer GE (1970) Dynamic blood coagulation and viscosity and degradation of artificial thrombi in patients with hypertension. Cardiovasc Res 4: 50–60PubMedCrossRefGoogle Scholar
  7. 7.
    Duguid JB, Anderson GS (1952) The pathogenesis of hyaline arteriosclerosis. J Path Bact 64: 519PubMedCrossRefGoogle Scholar
  8. 8.
    Folkow B, Hallbäck M, Lundgren Y, Weiss L (1970) Structurally based increase of flow resistance in spontaneously hypertensive rats. Acta Physiol Scand 79: 373–378PubMedCrossRefGoogle Scholar
  9. 9.
    Folkow B, Neil E (1971) Circulation. University Press, OxfordGoogle Scholar
  10. 10.
    Furness JB, Marshall JM (1974) Correlation of the directly observed responses of mesenteric vessels of the rat to nerve stimulation and noradrenaline within the distribution of adrenergic nerves. J Physiol 239: 75–88PubMedGoogle Scholar
  11. 11.
    Green HD, Schmid HE, Rapela CA (1964) Autoregulation in vascular beds–Possible role of autoregulation in the increased resistance to flow in hypertension. Hyperten 13: 144–159Google Scholar
  12. 12.
    Haack DW, Schaffer JJ, Simpson JG (1978) Cutaneous microvasculature of spontaneously hypertensive rats. Fed Proc 37: 350Google Scholar
  13. 13.
    Harper RN, Moore MA, Man MC, Watts LE, Hutchins PM (1978) Arteriolar rarefication in the conjunctiva of human essential hypertensives. Microvasc Res 16 (3): 369–372PubMedCrossRefGoogle Scholar
  14. 14.
    Hammersen F (1971) Anatomie der terminalen Strombahn. Muster - Feinbau - Funktion. Urban and Schwarzenberg, MünchenGoogle Scholar
  15. 15.
    Hammersen F (1981) Musterbildung und Struktur der terminalen Strombahn. In: Messmer, Fagrell (Hrsg) Mikrozirkulation und arterielle Verschlußkrankheiten, Karger, Basel, S 10–21Google Scholar
  16. 16.
    Hansson H-A, Johansson B, Blomstrand C (1975) Ultrastructural studies on cerebrovascular permeability in acute hypertension. Acta Neuropath 32: 178–198CrossRefGoogle Scholar
  17. 17.
    Henrich H, Eder M (1979) Sympathetic-adrenergic regulation of the microvasculature in spontaneously hypertensive rats. Bibl Anat 18: 187–189PubMedGoogle Scholar
  18. 18.
    Henrich H, Hertel R (1979) Hemodynamics and,rarefication` of the microvasculature in spontaneously hypertensive rats. Bibl Anat 18: 184–186PubMedGoogle Scholar
  19. 19.
    Henrich H, Hertel R (1981) Vasoconstrictor responses in consecutive sections of the hypertensive vasculature. Bibl Anat 20: 438–441Google Scholar
  20. 20.
    Henrich H, Hertel R, Assmann R (1978) Structural differences in the mesentery microcirculation between normotensive and spontaneously hypertensive rats. Pflügers Arch 375: 153–159PubMedCrossRefGoogle Scholar
  21. 21.
    Heydenreich A (1975) Innere Erkrankungen und Auge, Enke, StuttgartGoogle Scholar
  22. 22.
    Hilton SM, Lewin GP (1956) The relationship between glandular activity, bradikinin formation and functional vasodilatation in the submandibulary salivary gland. J Physiol 134: 471PubMedGoogle Scholar
  23. 23.
    Hutchins PM, Darnell AE (1974) Observations of a decreased number of small arterioles in spontaneously hypertensive rats. Circ Res 34/35, Suppl I: 161–165Google Scholar
  24. 24.
    Kristensen BO (1978) Increased serum levels of immunoglobulins in untreated and treated essential hypertension. Acta Med Scand 203: 49–54PubMedCrossRefGoogle Scholar
  25. 25.
    Mellander S, Johannson B (1968) Control of resistance, exchange and capacitance functions in the peripheral circulation. Pharmacol Rev 20: 117PubMedGoogle Scholar
  26. 26.
    Mel’Nikov HF (1963) State of coagulation at dif ferent stages in arterial hypertension. Fed Proc 22: T74Google Scholar
  27. 27.
    Palade GE, Simionescu M, Simionescu N (1979) Structural aspects of the permeability of the microvascular endothelium. Acta Physiol Scand (Suppl) 463: 11–32Google Scholar
  28. 28.
    Parving HH (1975) Microvascular permeability to plasma protein in hypertension and diabetes mellitus in man. On the pathogenesis of hypertensive and diabetic microangiopathy. Danish Med Bull 22: 217–230PubMedGoogle Scholar
  29. 29.
    Richardson JB, Beaulnes A (1971) The cellular site of action of angiotension. J Cell Biol 51: 419–432PubMedCrossRefGoogle Scholar
  30. 30.
    Roberts WC (1975) The hypertensive disease, evidence that systemic hypertension is a greater risk factor to the development of other cardiovascular diseases than previously suspected. Amer J Med 59: 523PubMedCrossRefGoogle Scholar
  31. 31.
    Rodin JAG (1967) The ultrastructure of mammalian arterioles and precapillary sphincters. J Ultrastruct Res 18: 181–223CrossRefGoogle Scholar
  32. 32.
    Rodin JAG (1973) Electron microscopic observations on small blood vessels. In: Darin de Lorenzo (ed) Vascular disorders in hearing defects. University Park Press, BaltimoreGoogle Scholar
  33. 33.
    Schmid-Schönbein H, Wells R (1969) Fluid drop-like transition of erythrocytes under shear. Science 165: 288–291CrossRefGoogle Scholar
  34. 34.
    Schmid-Schönbein H (1976) Microrheology of erythrocytes, blood viscosity, and the distribution of blood flow in the microcirculation. In: Guyton, Cowley (eds) International Rev of Physiol Vol IX, Cardiovasc Physiol II, University Park Press, Baltimore, p 1–62Google Scholar
  35. 35.
    Schömig A, Dietz R, Rauscher W (1979) Regulation of the intravascular volume and of the total peripheral resistance in spontaneous hypertensive rats. Bibl Anat 18: 177–179PubMedGoogle Scholar
  36. 36.
    Seiffge D, Klein B, Kremer E (1981) Effects of hemodilution in spontaneously hypertensive rats. Bibl Anat 20: 442–445Google Scholar
  37. 37.
    Siegenthaler W, Beckerhoff R, Vetter W, Würsten D, Siegenthaler G (1976) Essentielle Hypertonie, Symptom oder Krankheit? In: Zeitler E (Hrsg) Hypertonie, Risikofaktor in der Angiologie. Witzstrock, Baden-BadenGoogle Scholar
  38. 38.
    Strauer BE (1979) Ventricular function and coronary hemodynamics in hypertensive heart disease. Am J Cardiol 44: 999PubMedCrossRefGoogle Scholar
  39. 39.
    Takeda Y, Takeuchi T (1978) Studies of fibrinogen metabolism in healthy and hypertensive female subjects with the use of autologous J-125-fibrinogen. Thrombos Haemostas 39: 39–45Google Scholar
  40. 40.
    Tibblin G, Bergentz SE, Bjure J, Wilhelmsen L (1965) Hematocrit, plasma protein, plasma volume and viscosity in hypertensive disease. Scand J Clin Lab Invest (Suppl) 86: 194–198Google Scholar
  41. 41.
    Volger E (1980) Experimentelle und klinische Untersuchungen über die Rheologie des Blutes bei kardiovaskulären Erkrankungen und deren Risikofaktoren. Habilitationsschrift, Techn. Universität MünchenGoogle Scholar
  42. 42.
    Volger E, Klein J, Stoiber S, Blömer H (1981) Erythrocyte filtration in risk factors of cardio vascular diseases. Scand J Clin Lab Invest 41 (Suppl) 156: 273–275CrossRefGoogle Scholar
  43. 43.
    Wiener J, Spiro D, Lattes RG (1965) The cellular pathology of experimental hypertension. H. Arteriolar hyalinosis and fibrinoid change. Amer J Path 47: 457–485Google Scholar
  44. 44.
    Zweifach BW (1961) Functional behavior of the microcirculation. Thomas, Springfield/JUGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1984

Authors and Affiliations

  • E. Volger

There are no affiliations available

Personalised recommendations