Skip to main content

Hypertonie bei Hyperthyreose

  • Chapter
Arterielle Hypertonie

Zusammenfassung

Kardiovaskuläre Manifestationen der Hyperthyreose, wie Tachykardie, Tachyarrhythmie, Vorhofflimmern und systolischer Hochdruck, stehen häufig subjektiv und objektiv im Zentrum der klinischen Symptomatologie [37, 40, 46]. Sie sind bei Schilddrüsenfunktionsstörungen nicht nur eine wesentliche Hilfe in der Diagnostik, sondern auch in der Beurteilung des therapeutischen Erfolges. Die im Rahmen der Hyperthyreose beobachteten hämodynamischen Veränderungen, wie gesteigertes Herzminutenvolumen, erhöhtes Blutvolumen sowie reduzierter peripherer Gefäßwiderstand führen in ausgeprägten Fällen zur Steigerung des systolischen und Senkung des diastolischen Blutdruckes und damit zum typischen Pulsus celer et altus des hyperkinetischen Kreislaufsyndroms.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 54.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Amidi M, Leon DF, Groot WJ de, Krötz FW, Leonard JJ (1968) Effect of the thyroid state on myocardial contractility and ventricular ejection rate in man. Circulation 38: 229

    Article  PubMed  CAS  Google Scholar 

  2. Aoki VS, Wilson WR, Theilen EO, Lukensmeyer WW, Leaverton PE (1967) The effects of triiodothyronine on hemodynamic responses to epinephrine and norepinephrine in man. J Pharmacol Exp Ther 157: 62

    PubMed  CAS  Google Scholar 

  3. Brewster WR, Isaacs JP, Osgood PF, King TL (1956) The hemodynamic and metabolic interrelationships in the activity of epinephrine, nor-epinephrine and the thyroid hormones. Circulation 13: 1

    Article  PubMed  CAS  Google Scholar 

  4. Buccino RA, Spann JF, Pool PE, Sonnenblick EH, Braunwald E (1967) Influence of the thyroid state on the intrinsic contractile properties and energy stores of the myocardium. J Clin Invest 46: 1669

    Article  PubMed  CAS  Google Scholar 

  5. Christensen NJ (1972) Increased levels of plasma noradrenaline in hypothyroidism. J Clin Endocrinol Metab 35: 359

    Article  PubMed  CAS  Google Scholar 

  6. Coulombe P, Dussault JH, Letarte J, Simard SJ (1976) Catecholamine metabolism in thyroid diseases. I. Epinephrine secretion rate in hyperthyroidism and hypothyroidism. J Clin Endocrinol Metab 42: 125

    Google Scholar 

  7. Coulombe P, Dussault JH, Walker P (1976) Plasma catecholamine concentrations in hyperthyroidism and hypothyroidism. Metabolism 25: 973

    Article  PubMed  CAS  Google Scholar 

  8. Coulombe P, Dussault JH, Walker P (1977) Catecholamine metabolism in thyroid disease. II. Norepinephrine secretion rate in hyperthyroidism and hypothyroidism. J Clin Endocrinol Me-tab 44: 1185

    Google Scholar 

  9. Crawford DG, Fairchild HM, Guyton AC (1959) Oxygen lack as a possible cause of reactive hyperemia. J Am Physiol 197: 613

    CAS  Google Scholar 

  10. Distler A, Philipp T, Lüth B, Zschiedrich H, Cordes U (1981) Interrelationships between plasma norepinephrine and blood pressure response to norepinephrine in normotension and hypertension. In: Laragh JH, Bühler FR, Seldin DW (eds). Frontiers in Hypertension Research. Springer, New York, S 297–300

    Chapter  Google Scholar 

  11. Doherty JE, Perkins WH (1966) Digoxin metabolism in hypo-and hyperthyroidism. Studies with tritiated digoxin in thyroid disease. Ann Intern Med 64: 489

    Google Scholar 

  12. Gibson JG, Harris AW (1939) Clinical studies of the blood volume. V. Hyperthyroidism and myxedema. J Clin Invest 18: 59

    Google Scholar 

  13. Goodkind MJ (1966) The influence of thyroid hormone on myocardial metabolism of norepinephrine in the guinea pig. J Pharmacol Exp Ther 154: 531

    PubMed  CAS  Google Scholar 

  14. Goodkind MJ, Dambach GE, Thyrum PT, Luchi RJ (1974) Effect of thyroxine on ventricular myocardial contractility and ATPase activity in guinea pigs. Am J Physiol 226: 66

    PubMed  CAS  Google Scholar 

  15. Groot WJ de, Leonard JJ (1970) Hyperthyroidism as a high cardiac output state. Am Heart J 79: 265

    Article  Google Scholar 

  16. Grossman W, Robin NI, Johnson LW, Brooks HL, Selenkow HA, Dexter L (1971) The enhanced myocardial contractility of thyrotoxicosis. Ann Intern Med 74: 869

    PubMed  CAS  Google Scholar 

  17. Guttler RB, Croxson MS, Quattro VL de, Warren DW, Otis CL, Nicoloff JT (1977) Effects of thyroid hormone on plasma adenosine 3’, 5’-monophosphate production in man. Metabolism 26: 1155

    Article  PubMed  CAS  Google Scholar 

  18. Guyton AC (1963) Effect of tissue oxygen need on cardiac output. In: Guyton AC, Jones CE, Coleman TG (eds) Circulatory physiology: cardiac output and its regulation. Saunders Company, Eastbourne, p 301

    Google Scholar 

  19. Harrison TS (1964) Adrenal medullary and thyroid relationships. Physiol Rev 44: 161

    PubMed  CAS  Google Scholar 

  20. Hertzman AB (1959) Vasomotor regulation of cutaneous circulation. Physiol Rev 39: 280

    PubMed  CAS  Google Scholar 

  21. Hirvonen L, Lang H (1962) Thyroid activity and heart rate. Proc Soc Exp Biol Med 109: 284

    PubMed  CAS  Google Scholar 

  22. Huckabee WE (1961) Effects of phosphorylative uncoupling in tissues on cardiac output of intact animals. Fed Proc 20: 13 (Abstract)

    Google Scholar 

  23. Humerfelt S, Müller O, Storstein O (1958) The circulation in hyperthyroidism: a cardiac catheterization study before and after treatment. Am Heart J 56: 87

    Article  PubMed  CAS  Google Scholar 

  24. Hurxthal LM (1931) Blood pressure before and after operation in hyperthyroidism. Arch Intern Med 47: 167

    Article  Google Scholar 

  25. Jose AD (1966) Effect of combined sympathetic and parasympathetic blockade on heart rate and cardiac function in man. Am J Cardiol 18: 476

    Article  PubMed  CAS  Google Scholar 

  26. Kontos HA, Shapiro W, Mauck HP, Richardson DW, Patterson JL, Sharpe AR (1965) Mechanism of certain abnormalities of the circulation to the limbs in thyrotoxicosis. J Clin Invest 44: 947

    Article  PubMed  CAS  Google Scholar 

  27. Krötz F, Groot WJ de, Leonard JJ, Warren JV (1962) The relationship of oxygen consumption to hemodynamic response in hypermetabolic states. Circ Res 10: 19 (Abstract)

    Google Scholar 

  28. Levey GS (1971) Catecholamine sensitivity, thyroid hormone and the heart. Am J Med 50: 413

    Article  CAS  Google Scholar 

  29. Levey GS, Epstein SE (1969) Myocardial adenyl cyclase: activation by thyroid hormones and evidence for two adenyl cyclase systems. J Clin Invest 48: 1663

    Article  PubMed  CAS  Google Scholar 

  30. Levey GS, Skelton CL, Epstein SE (1969) Influence of hyperthyroidism on the effects of norepinephrine on myocardial adenyl cyclase activity and contractile state. Endocrinology 85: 1004

    Article  PubMed  CAS  Google Scholar 

  31. Margolius HS, Gaffney TE (1965) The effects of injected norepinephrine and sympathetic nerve stimulation in hypothyroid and hyperthyroid dogs. J Pharmacol Exp Ther 149: 329

    PubMed  CAS  Google Scholar 

  32. Massey DG, Becklake MR, McKenzie JM, Bates DV (1967) Circulatory and ventilatory response to exercise in thyrotoxicosis. N Engl J Med 276: 1104

    Article  PubMed  CAS  Google Scholar 

  33. Pool PE, Skelton CL, Seagren SC, Braunwald E (1968) Chemical energetics of cardiac muscle in hyperthyroidism. J Clin Invest 47: 80 (Abstract)

    Google Scholar 

  34. Ross JM, Fairchild HM, Weldy J, Guyton AC (1962) Autoregulation of blood flow by oxygen lack. Am J Physiol 202: 21

    PubMed  CAS  Google Scholar 

  35. Schoot JB van der, Moran NC (1965) An experimental evaluation of the reputed influence of thyroxine on the cardiovascular effects of catecholamines. J Pharmacol Exp Ther 149: 336

    PubMed  Google Scholar 

  36. Skelton CL, Coleman NH, Wildenthal K, Braunwald E (1970) Augmentation of myocardial oxygen consumption in hyperthyroid cats. Circ Res 37: 301

    Article  Google Scholar 

  37. Sobel BE, Braunwald E (1971) Cardiovascular system. In: Werner SC, Ingbar SH (eds) The Thyroid. Harper & Row, Hagerstown, Maryland, p 551

    Google Scholar 

  38. Stainsby WN (1962) Autoregulation of blood flow in skeletal muscle during increased metabolic activity. Am J Physiol 202: 273

    PubMed  CAS  Google Scholar 

  39. Stoffer SS, Jiang NS, Gorman CA, Pikler GM (1973) Plasma catecholamines in hypothyroidism and hyperthyroidism. J Clin Endocrinol Metab 36: 587

    Article  PubMed  CAS  Google Scholar 

  40. Summers VK, Surtees SJ (1961) Thyrotoxicosis and heart disease. Acta Med Scand 169: 661

    Article  Google Scholar 

  41. Taylor RR (1970) Contractile properties of cardiac muscle in hyperthyroidism. Circ Res 27: 539

    Article  PubMed  CAS  Google Scholar 

  42. Tech PC, Cheah JS, Chia BL (1974) Effect of adrenergic blockade and specific antithyroid therapy on electrocardiographic changes in hyperthyroidism. Am J Med Sci 268: 157

    Article  Google Scholar 

  43. Theilen EO, Wilson WR (1967) Hemodynamic effects of peripheral vasoconstriction in normal and thyrotoxic subjects. J Appl Physiol 22: 207

    PubMed  CAS  Google Scholar 

  44. Thompson WO, Dickie LFN, Morris AE, Hilkevitch BH (1931) The high incidence of hypertension in toxic goiter and in myxedema. Endocrinology 15: 265

    Article  Google Scholar 

  45. Vana S, Nemec J (1976) Critical evaluation of the diagnostic value of systolic time intervals in the diagnosis of functional thyroid diseases. Comparison of results in a highly selected and a non-selected group of patients in relation to the blood PBI and T4I levels. Endokrinologie 68: 164

    PubMed  CAS  Google Scholar 

  46. Wenger NK, Herndon EG (1974) Endocrine and metabolic disorders. In: Hurst JW (ed) The heart, arteries and veins. McGraw-Hill Kogakusha, p 1478

    Google Scholar 

  47. Wilson WR, Theilen EO, Fletcher FW (1964) Pharmacodynamic effects of betaadrenergic receptor blockade in patients with hyperthyroidism. J Clin Invest 43: 1697

    Article  PubMed  CAS  Google Scholar 

  48. Wilson WR, Theilen EO, Hege JH, Valenca MR (1966) Effects of beta-adrenergic receptor blockade in normal subjects before, during, and after triiodothyronine-induced hypermetabolism. J Clin Invest 45: 1159

    Article  PubMed  CAS  Google Scholar 

  49. Wiswell JG, Hurwitz GE, Coronho V, Bing OHL, Child DL (1963) Urinary catecholamines and their metabolites in hyperthyroidism and hypothyroidism. J Clin Endocrinol Metab 23: 1102

    Article  PubMed  CAS  Google Scholar 

  50. Wurtman RJ, Kopin IJ, Axelrod J (1963) Thyroid function and the cardiac disposition of catecholamines. Endocrinology 73: 63

    Article  PubMed  CAS  Google Scholar 

  51. Young RT, Herle AJ van, Rodbard D (1976) Improved diagnosis and management of hyper-and hypothyroidism by timing the arterial sounds. J Clin Endocrinol Metab 42: 330

    Article  PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1984 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Waldhäusl, W.K., Bratusch-Marrain, P.R. (1984). Hypertonie bei Hyperthyreose. In: Rosenthal, J. (eds) Arterielle Hypertonie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-00760-0_13

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-00760-0_13

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-00761-7

  • Online ISBN: 978-3-662-00760-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics