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Entwicklungsstörungen

  • Manfred Hansmann
  • Bernhard-Joachim Hackelöer
  • Alfons Staudach
Chapter

Zusammenfassung

Während in den ersten 10 Anwendungsjahren der Ultraschalldiagnostik die Fetalbiometrie zur Gestationsalterssicherung und Kontrolle der somatischen Entwicklung im Vordergrund stand, hat sich in den vergangenen 5 Jahren (1979–1984) die Mißbildungsdiagnostik als neuer Schwerpunkt etabliert. Die Voraussetzungen hierfür wurden einerseits durch den technischen Fortschritt in dem bildgebenden Verfahren „Impulsechographie“ und andererseits durch Integration des „Ultraschalls“ als Screeningmethode in die Schwangerenvorsorge (seit 1. Januar 1980) geschaffen.

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Literatur

  1. Hansmann M (1981) Nachweis und Ausschluß fetaler Entwicklungsstörungen mittels Ultraschallscreening und gezielter Untersuchung — ein Mehrstufenkonzept. Ultraschall 2: 206CrossRefGoogle Scholar
  2. Hepp H (1982) Schwangerschaftsabbruch aus kindlicher Indikation — anthropologisch — philosophische Aspekte des Arzt-Patienten-Konfliktes. In: Boland P, Krone HA, Pfeiffer RA (Hrsg) Wissenschaftliche Informationen, Bamberger Symposium. Milupa, FriedrichsdorfGoogle Scholar
  3. Holländer HJ (19722, 19753, 1984) Die Ultraschalldiagnostik in der Schwangerschaft. Urban & Schwarzenberg, München Wien BaltimoreGoogle Scholar
  4. Queenan JT, Thompson W (1972) Amniotic fluid volumes in normal pregnancies. Am J Obstet Gynecol 114: 34PubMedGoogle Scholar
  5. Ramzin MS, Meudt RO, Hinselmann JJ (1973) Prognostic significance of abnormal ultrasonographic findings during the second trimester of gestation. J Perinat Med 1:60PubMedCrossRefGoogle Scholar
  6. Birnholz JC, Frigoletto FD (1981) Antenatal treatment of hydrocephalus. N Engl J Med 30:1021CrossRefGoogle Scholar
  7. Bliesener JA (1984) Sonographie der normalen und pathologischen Hirnanatomie bei Neugeborenen und Säugling. Habilitationsschrift, KölnGoogle Scholar
  8. Book JA, Schult JW, Reed SC (1953) A clinical and genetical study of microcephaly. Am J Ment Defic 57: 637PubMedGoogle Scholar
  9. Campbell S (1979) Early prenatal diagnosis of fetal abnormality by ultrasound B-scanning. In: Murken JD, Stengel-Rutkowski S, Schwinger E (eds) Renetal diagnosis. Enke, Stuttgart, S 183Google Scholar
  10. Campbell S, Griffin D, Little D (1981) Ultrasonic diagnosis of cranial spinal defects. In: Kurjak A, Kratochwill A (eds) Recent advances in ultrasound diagnosis. 3. Excerpta Medica International Congress Series 553, AmsterdamGoogle Scholar
  11. Chinn DH, Fill RA (1983) Extensive intracranial hemorrhage in utero. J Ultrasound Med 2:285PubMedGoogle Scholar
  12. Dann StM, Di Pietro MA, Faix RG, Bowermann RA (1983) The sonographic appearance of old intraventricular hemorrhage present a birth. J Ultrasound Med 2:2–3Google Scholar
  13. Dempsey PJ, Koch HJ (1981) In utero diagnosis of Dandy-Walker-Syndrome: Differentiation from extra-axial posterior fossa cyst. J Clin Ultrasound 9: 403PubMedCrossRefGoogle Scholar
  14. Denkhaus H, Winsberg F (1979) Ultrasonic measurement of the fetal ventricular system. Radiology 131: 781PubMedGoogle Scholar
  15. Fischer EG (1973) Dandy-Walker-Syndrome: an evaluation of surgical treatment. J Neurosurg 39: 615PubMedCrossRefGoogle Scholar
  16. Garret WJ (1979) Ultrasound in discerning normal fetal anatomy. In: Hobbins JC (ed) Diagnostic ultrasound in obstetrics. Churchill Livingstone, New York Edinburgh LondonGoogle Scholar
  17. Garret WJ, Fisher CC, Kosoff G (1975) Hydrocephaly, microcephaly and anencephaly diagnosed in pregnancy by ultrasonic echography. Med J Aust 2: 587Google Scholar
  18. Hadlock FP, Deter RL, Park SK (1981) Real-time sonography: Ventricular and vascular anatomy of the fetal brain in utero. AJR 136:137Google Scholar
  19. Hartung RW, Yiu-Chiu V (1983) Demonstration of unilateral hydrocephalus in utero. J Ultrasound Med 2: 369PubMedGoogle Scholar
  20. Hobbins JC, Winsberg F, Berkowitz RL (1983) Ultrasonography in obstetrics and gynecology. Wiliams & Wilkins, Baltimore LondonGoogle Scholar
  21. Jeanty P, Rodesch F (1981) Is antenatal diagnosis enough? Free lecture: 4th European congress on ultrasonics in medicine, DubrovnikGoogle Scholar
  22. Jeanty P, Romero R (1984) Obstetrical ultrasound. McGraw-Hill, New YorkGoogle Scholar
  23. Kim MS, Elyaderani MK (1982) Sonographic diagnosis of cerebro-ventricular hemorrhagic in utero. Radiology 142:479PubMedGoogle Scholar
  24. Koch G (1959) Genetics of microcephaly in man. Acta Genet Med Gemellol (Roma) 8: 75Google Scholar
  25. Kurtz AB, Wappner RJ, Rubin CS, Cole-Beuglet C, Ross RD, Goldberg BB (1980) Ultrasound criteria for in utero diagnosis of microcephaly. J Clin Ultrasound 8:11PubMedCrossRefGoogle Scholar
  26. Lee TG, Warren BH (1977) Antenatal diagnosis of hydranencephaly by ultrasound: Correlation with ventriculography and computed tomography. J Clin Ultrasound 5: 271PubMedCrossRefGoogle Scholar
  27. Rose JS (1977) The ultrasound diagnosis of fetal neural tube abnormalities. Ann Radiol 1:19Google Scholar
  28. Staudach A, Laßmann R (1984) Ultraschalldiagnostik von fetalen Mißbildungen. Oester Aerztetg 39/7: 476Google Scholar
  29. V.K. Collaborative Study (1977) On alpha-fetoprotein in relation to neural tube defects. Maternal serumalpha-fetoprotein measurement in antenatal screening for anencephaly and spina bifida in early pregnancy. Lancet I:1323Google Scholar
  30. Warkany J (1971) Congenital malformation. Year Book Medical Publishers, ChicagoGoogle Scholar
  31. Brandesky G (1973) Zwerchfell. In: Kunz H (Hrsg) Operationen im Kindesalter. Thieme, StuttgartGoogle Scholar
  32. Dunne MG, Johnson ML (1979) The ultrasonic demonstration of fetal abnormalities in utero. J Reprod Med 23:195PubMedGoogle Scholar
  33. Giulian BB, Alvear DT (1978) Prenatal ultrasonographic diagnosis of fetal gastroschisis. Radiology 129:473PubMedGoogle Scholar
  34. Hansmann M (1984) Möglichkeiten und Grenzen sonographischer Diagnostik bei fetalen Erkrankungen und Mißbildungen. In: Kowalewski (Hrsg) Pädiatrische Intensivmedizin VI. Thieme, Stuttgart New YorkGoogle Scholar
  35. Harrison MR (1983) Perinatal management of the fetus with a caretable defect. In: Callen PW (ed) Ultrasonography in obstetrics and gynecology. Sounders, Philadelphia London TorontoGoogle Scholar
  36. Harrison MR, De Lorimier AA (1981) Congenital diaphragmatic hernia. Surg Clin North Am 61:1023PubMedGoogle Scholar
  37. Harrison MR, Bressack MA, Churg AM (1980) Correction of congenital diaphragmatic hernia in utero. II. Simulated correction permits fetal lung growth with survival at birth. Surgery 88:260PubMedGoogle Scholar
  38. Jeanty P, Romero R (1984) Obstetrical ultrasound. Mc Graw, New YorkGoogle Scholar
  39. Lomar F, Stattford-Bell M, Tymms A (1979) Prenatal ultrasound in diagnosis and management of fetal exomphalos case reports. Br J Obstet Gynecol 86: 581CrossRefGoogle Scholar
  40. Meyenburg M, Maaßen V (1979) Praepartale Erkennung einer Omphalocele. Geburtshilfe Frauenheilkd 39: 1021PubMedGoogle Scholar
  41. Moore KL (1980) Embryologie. Schattauer, Stuttgart New YorkGoogle Scholar
  42. Niesen M, Hansmann M (1979) Omphalocele, praepar-tale Ultraschalldiagnostik und Konsequenzen. Gynäkologe 12:80Google Scholar
  43. Roberts C (1978) Intrauterine diagnosis of omphalocele. Radiology 127:762PubMedGoogle Scholar
  44. Schaffer RM, Barone C, Friedman A (1983) The ultrasonographic spectrum of fetal omphalocele. J Ultrasound Med 2:219PubMedGoogle Scholar
  45. Schmidt W, Gabelmann J, Garoff L, Kubli F (1981) Ultrasonographische Diagnose einer Omphalocele im ersten Schwangerschaftsdrittel. Geburtshilfe Frauenheilkd 41: 562PubMedCrossRefGoogle Scholar
  46. Scott JS, Wilson JK (1957) Hydramnions as an early sign of oesophageal atresia. Lancet II: 569CrossRefGoogle Scholar
  47. Staudach A, Laßmann R, Menzel C (1982) Mißbil-dungsdiagnostik vor der 24. Woche. In: Kratochwill A, Reinold R (Hrsg) Ultraschalldiagnostik 1981. Thieme, Stuttgart New YorkGoogle Scholar
  48. Staudach A, Laßmann R, Rosenkranz W, Engels M, Joos H, Rücker J (1984) Praenatale Diagnose fetaler Entwicklungsstörungen, das Modell eines interdisziplinären Teams. In: Kowalewski (Hrsg) Pädiatrische Intensivmedizin VI. Thieme, Stuttgart New YorkGoogle Scholar
  49. Warkany J (1971) Congenital malformation. Year Book Medical Publishers, ChicagoGoogle Scholar
  50. Winter R (1981) Die Diagnose angeborener Mißbildungen mittels Ultraschall. Ultraschall 2: 235CrossRefGoogle Scholar
  51. Zaleski AM, Cooperberg PL, Kliman MR (1979) Ultrasonic diagnosis of extrafetal masses. J Can Assoc Radiol 30: 55PubMedGoogle Scholar
  52. Bain AD, Scott JS (1960) Renal agenesis and severe urinary tract dysplasia. Br Med J I: 841CrossRefGoogle Scholar
  53. Campbell S, Wladimiroff JW, Dewhurst CJ (1973) The antenatal measurement of fetal urine production. Br J Obstet Gynecol 80: 680CrossRefGoogle Scholar
  54. Grannum P, Bracken M, Silverman R, Hobbins JC (1980) Assessment of kidney size in normal gestation by comparison of ratio od kidney circumference to abdominal circumference. Am J Obstet Gynecol 136: 249PubMedGoogle Scholar
  55. Hansmann M, Niesen M, Födisch J (1979) Praenatale Ultraschalldiagnose des Potter-Syndroms. Gynäkologe 12: 69Google Scholar
  56. Harrison MR (1983) Perinatal management of the fetus with a correctable defect. In: Callen PW (ed) Ultrasonography in obstetrics and gynecology. Sounders, PhiladelphiaGoogle Scholar
  57. Knöpfle G, Födisch HJ, Hansmann M (1982) Das Potter-Syndrom. Prä- und postnatale Diagnostik. Verh Dtsch Ges Pathol 66: 278PubMedGoogle Scholar
  58. Mc Crory WW (1972) Developmental nephrology. Harvard University, Cambridge, p 40Google Scholar
  59. Merin PR, Portter M, Dallaire L, Melancon SB, Boisuert J (1981) Prenatal detection of the autosomal recessive type of polycystic kidney disease by trehalase assay in amniotic fluid. Prenat Diagn 1:75CrossRefGoogle Scholar
  60. Oliver J (1968) Nephrons and kidneys. Harper & Row, New York, p 1Google Scholar
  61. Potter EL (1946a) Bilateral renal agenesis. J Pediatr 29:68PubMedCrossRefGoogle Scholar
  62. Potter EL (1946b) Facial characteristics of infants with bilateral renal angenesis. Am J Obstet Gynecol 51:885PubMedGoogle Scholar
  63. Potter EL (1965) Bilateral absence of ureters and kidneys. A report of 50 cases. Obstet Gynecol 25:3PubMedGoogle Scholar
  64. Potter EL (1972) Normal and abnormal development of the kidney. ChicagoGoogle Scholar
  65. Queenan JT, Thompson W (1972) Amniotic fluid volumes in normal pregnancies. Am J Obstet Gynecol 114: 34PubMedGoogle Scholar
  66. Ratten GJ, Beischer NA, Fortune DW, Path MRC (1973) Obstetric complications when the fetus has Potter’s syndrome. Am J Obstet Gynecol 115: 890PubMedGoogle Scholar
  67. Staudach A, Laßmann R, Rosenkranz W, Engels M, Joos H, Rücker J (1984) Pränatale Diagnose fetaler Entwicklungsstörungen, das Modell eines interdisziplinären Teams. In: Kowalewski (Hrsg) Pädiatrische Intensivmedizin VI. Thieme, Stuttgart New YorkGoogle Scholar
  68. Straub E (1983) Pädiatrisch-urologische Gesichtspunkte. In: Hohenfellner R, Zingg EJ (Hrsg) Urologie in Klinik und Praxis. Thieme, Stuttgart New YorkGoogle Scholar
  69. Warkany J (1971) Congenital malformations. Year Book Medical Publishers. Chicago 1036Google Scholar
  70. Weiß H, Zerres K, Hansmann M (1981) Pränatale Diagnose zystischer Nierenveränderungen mit Hilfe der Ultraschalltechnik. Ultraschall 2: 244CrossRefGoogle Scholar
  71. Zerres K (1981) Zystennieren, klinische, pathologisch anatomische und genetische Gesichtspunkte. Dissertation, BonnGoogle Scholar
  72. Hamburg K, Grossheim M, Födisch JH, Schwanitz G (1982) Leitsymptom: Radiusaplasie. Verh Dtsch Ges Pathol 66: 475Google Scholar
  73. Hobbins JC, Mahoney MJ (1980) The diagnosis of skeletal dysplasis with ultrasound. In: Sanders RC, James AE (eds) The principles and pratice of ultrasonography in obstetrics and gynecology, 2nd edn. AppletonCentury-Crofts, New York, pp 191, 203Google Scholar
  74. Lang M, Hansmann M, Bellmann O, Azubuike J (1979) Thanatophorer Zwergwuchs — pränatale Diagnostik und Geburtsleitung. Gynäkologe 12:84Google Scholar
  75. Langer LO, Spranger JW, Greinacker I, Herdmann RC (1969) Thanatophoric dwarfism. Radiology 92: 285PubMedGoogle Scholar
  76. Maroteaux P, Lainy M, Robert JM (1967) Le nanisme thanatophore. Presse Med 75: 2519PubMedGoogle Scholar
  77. Richardson MM, Beaudet AL, Wagner ML, Malini S, Rosenberg HS, Lucci JA (1977) Prenatal diagnosis of reccurence of saldino-noonan dwarfism. J Pediat 91: 467PubMedCrossRefGoogle Scholar
  78. Smith WL, Breitweiser TD, Dinno N (1981) In utero diagnosis of achondrogenesis typ I. Clin Genet 19: 51PubMedCrossRefGoogle Scholar
  79. Staudach A, Laßmann R, Menzel C (1982) Mißbildungsdiagnostik vor der 24. Woche. In: Kratochwill A, Reinold E (Hrsg) Ultraschalldiagnostik 81. Thieme, Stuttgart New YorkGoogle Scholar
  80. Thompson BH, Parmley TH (1971) Obstetric features of thanatophoric dwarfism. Am J Obstet Gynecol 109: 396PubMedGoogle Scholar
  81. Winter R, Rosenkranz W (1984) Kampomele Dysplasie. In: Kowalewski (Hrsg) Perinatale Intensivmedizin VI. Thieme, Stuttgart New YorkGoogle Scholar
  82. Donn SM, Martin JN, White SJ (1981) Antenatal ultrasound findings in cystic adenomatoid malformation. Pediatr Radiol 10:180PubMedCrossRefGoogle Scholar
  83. Ehmann RL, Nicholson StF, Machin GA (1983) Prenatal sonographic detection of congenital mesoblastic nephrome in a monozygotic twin pregnancy. J Ultrasound Med 2:555Google Scholar
  84. Garret WJ, Kossoff F, Lawrence R (1975) Gray scale echography in the diagnosis of hydrops due to fetal lung tumor. J Clin Ultrasound 3:45CrossRefGoogle Scholar
  85. Goerttler KI (1964) Kyematopathien. In: Becker PE (Hrsg) Humangenetik, Bd II. Thieme, StuttgartGoogle Scholar
  86. Knochel JQ, Lee TG, Melendez MU, Henderson SC (1983) Fetal anomalies involving the thorax and abdomen. In: Callen PW (ed) Ultrasonography in obstetrics and gynecology. Sounders, Philadelphia London TorontoGoogle Scholar
  87. Nakamoto StK, Dreilinger A, Dattel B, Mattrey RF, Key TC (1983) The sonographic appearance of hepatic hemangioma in utero. J Ultrasound Med 2: 239PubMedGoogle Scholar
  88. Schaller A (1975) Geburtsmedizinische Teratologie. Urban & Schwarzenberg, München Berlin WienGoogle Scholar
  89. Staudach A (1982) Möglichkeit und Grenzen der Mißbildungsdiagnostik. Swiss Med 4: 67, 68Google Scholar
  90. Allan LD, Tynan MJ, Campbell S, Wilkinson JL, Anderson RH (1980) Echocardiographic and anatomical correlates in the fetus. Br Heart J 44: 444PubMedCrossRefGoogle Scholar
  91. Davis CL (1982) Diagnosis and management of nonimmune hydrops fetalis. J Reprod Med 27: 594PubMedGoogle Scholar
  92. DeVore GR, Siassi B, Platt LD (1983) Fetal echocardiography. III. The diagnosis of cardiac arrhythmias using real-time-directed M-Mode ultrasound. Am J Obstet Gynecol 146: 792PubMedGoogle Scholar
  93. Dumesic DA, Silverman NH, Tobias S, Golbus MS (1982) Transplacental cardioversion of fetal supraventricular tachycardia with procainamide. N Engl J Med 307: 1128PubMedCrossRefGoogle Scholar
  94. Etches PC, Lemons JA (1979) Nonimmune hydrops fetalis: Report of 22 cases including three siblings. Pediatrics 64:326PubMedGoogle Scholar
  95. Gembruch U, Venn HJ, Redel DA, Hansmann M (1982) Wolff-Parkinson-White-Syndrom mit paroxysmalen supraventrikulären Tachykardien des Feten und des Neugeborenen — Fallbeschreibung. Klin Pädiat 194: 320CrossRefGoogle Scholar
  96. Hansmann M (1981) Nachweis und Ausschluß fetaler Entwicklungsstörungen mittels Ultraschallscreening und gezielter Untersuchung — ein Mehrstufenkonzept. Ultraschall 2: 206CrossRefGoogle Scholar
  97. Hansmann M, Gembruch U (1984) Gezielte sonographische Ausschlußdiagnostik fetaler Fehlbildungen in Risikogruppen. Gynäkologe 17:19PubMedGoogle Scholar
  98. Hansmann M, Redel DA (1982) Prenatal symptoms and clinical management of heart disease. In: Ler symposium international d’echocardiologie foetale, Strasbourg 1982, p 137Google Scholar
  99. Hansmann M, Redel DA, Födisch HJ (1982) Premature obstruction of the foramen ovale detected, treated and reconfirmed by help of ultrasound. In: Burruto F, Hansmann M, Wladimiroff JW (eds) Fetal ultrasonography: The secret prenatal life. Wiley, Chichester New York, p 151Google Scholar
  100. Kleinman CS, Hobbins JC, Jaffe CC, Lynch DC, Talner NS (1980) Echocardiographic studies of the human fetus: prenatal diagnosis of congenital heart disease and cardiac dysrhythmias. Pediatrics 65:1059PubMedGoogle Scholar
  101. Kleinman CS, Donnerstein RL, DeVore GR, Jaffe CC, Lynch DC, Berkowitz RL, Talner NS, Hobbins JC (1982) Fetal echocardiography for evaluation of in utero congestive heart failure. N Engl J Med 306: 568PubMedCrossRefGoogle Scholar
  102. Kleinman CS, Donnerstein RL, Jaffe CC, DeVore GR, Weinstein EM, Lynch DC, Talner NS, Berkowitz RL, Hobbins JC (1983) Fetal echocardiography. A tool for evaluation of in utero cardiac arrhythmias and monitoring of in utero therapy: Analysis of 71 patients. Am J Cardiol 51:237PubMedCrossRefGoogle Scholar
  103. Leake RD, Strimling B, Emmanouilides GC (1973) Intrauterine cardiac failure with hydrops fetalis, Case report in a twin with the hypoplastic left heart syndrome and review of the literature. Clin Pediatr 12: 649Google Scholar
  104. Maidman JE, Yeager C, Anderson V, Makabali G, O’Grady P, Arce J, Tishler DM (1980) Prenatal diagnosis and management of nonimmunologic hydrops fetalis. Obstet Gynecol 56: 571PubMedGoogle Scholar
  105. Nora JJ, Nora AH (1978) The evolution of specifiic genetic and environment counseling in congenital heart diseases. Circulation 57:205PubMedCrossRefGoogle Scholar
  106. Perlin BM, Pomerance JJ, Schifrin BS (1981) Nonimmunologic hydrops fetalis. Obstet Gynecol 57: 584PubMedGoogle Scholar
  107. Redel DA, Hansmann M (1981) Fetal obstruction of the foramen ovale detected by two-dimensional doppler echocardiography. In: Rijsterborgh H (ed) Echocardiology. Nijhoff, The Hague Boston London, p 425CrossRefGoogle Scholar
  108. Redel DA, Hansmann M (1984) Fetale Echokardiographie — ihre Anwendung in Diagnostik und Therapie. Gynäkologe 17: 41PubMedGoogle Scholar
  109. Rudolph A (1974) Congenital diseases of the heart. Year Book Medical Publishers, ChicagoGoogle Scholar
  110. Sahn DJ, Lange LW, Allen HD, Goldberg SJ, Anderson C, Giles H, Haber K (1980) Quantitative real-time cross-sectional echocardiography in the developing normal human fetus and newborn. Circulation 62: 588PubMedCrossRefGoogle Scholar
  111. Sahn DJ, Shenker L, Reed KL, Valdes-Cruz LM, Sobonya R, Anderson C (1982) Prenatal ultrasound diagnosis of hypoplastic left heart syndrome in utero associated with hydrops fetalis. Am Heart J 104:1368PubMedCrossRefGoogle Scholar
  112. Tamari I, Eldar M, Rabinowitz B, Neufeld HN (1982) Medical treatment of cardiovascular disorders during pregnancy. Am Heart J 104:1357PubMedCrossRefGoogle Scholar
  113. Artner J, Irsigler K, Ogris E, Rosenkranz A et al. (1981) Diabetes und Schwangerschaft. Z Geburtshilfe Perinatol 185:125PubMedGoogle Scholar
  114. Aula P, Rapola J, Karjalainen O, Lindgren J, Hartikainen A, Seppälä M (1978) Prenatal diagnosis of congenital nephrosis in 23 high-risk families. Am J Dis Child 132:984PubMedGoogle Scholar
  115. Bean WJ, Calonje MA, Aprill CN, Geshner J (1978) Anal atresia: A prenatal ultrasound diagnosis. J Clin Ultrasound 6:111PubMedCrossRefGoogle Scholar
  116. Brock DJH (1979) Prenatal diagnosis of neural tube defects. In: Weitzel HK, Schneider J (eds) Alpha-Fetoprotein in clinical medicine. Thieme, Stuttgart New York, pp 1–7Google Scholar
  117. Carter CO, Evans K, Pescia G (1979) A family study of renal agenesis. J Med Genet 16:176PubMedCrossRefGoogle Scholar
  118. Claussen U, Hansmann M (1984) Die „Pipettenmethode“ zur schnellen Karyotypisierung bei sonographischen Verdachtskriterien für eine Chromosomenanomalie. Gynäkologe 17:1Google Scholar
  119. Cohen T, Stern E, Rosenmann A (1979) Sib risk of neural tube defect: Is prenatal diagnosis indicated in prognancies following the birth of a hydrocephalic child? J Med Genet 16:14PubMedCrossRefGoogle Scholar
  120. Filly RA, Golbus MS, Carey JC, Hall JG (1981) Shortlimbed dwarfism: Ultrasonographic diagnosis by mensuration of fetal femoral length. Radiology 138: 653PubMedGoogle Scholar
  121. Födisch HJ (1982) Pathologisch-anatomische Mißbildungsdiagnostik — Heute. Verh Dtsch Ges Pathol 66:37PubMedGoogle Scholar
  122. Födisch HJ, Knöpfle G (1984) Patho-anatomische Teratologie — eine aktuelle Herausforderung. Gynäkologe 17: 2–12PubMedGoogle Scholar
  123. Fuhrmann W (1983) Die Alpha-Fetoproteinbestimmung in der pränatalen Diagnostik und Vorsorge. Diagn Intensivther 6:1Google Scholar
  124. Gembruch U, Venn HJ, Gembruch G, Hansmann M (1983) Ergebnisse der gezielten „frühen“ pränatalen Ausschlußdiagnostik von Mißbildungen mittels Ultraschall. In: Otto RC, Jann FX (Hrsg) Ulttraschalldiagnostik 82, Interventionelle Sonographie. Thieme, Stuttgart New York, S 159–161Google Scholar
  125. Gembruch U, Bellmann O, Hansmann M (1984) Die gezielte sonographische Mißbildungsdiagnostik bei Feten mit erhöhten Alpha-Fetoprotein-Konzentrationen. In: Lutz H, Reiche L (Hrsg) Ultraschalldiagnostik 83, Drei-Länder-Treffen Erlangen 1983. Thieme, Stuttgart New York (im Druck)Google Scholar
  126. Golbus MS, Holzgreve W, Harrison NR (1984) Intrauterine Direktbehandlung des Feten. Gynäkologe 17: 62PubMedGoogle Scholar
  127. Grannum P, Bracken M, Silverman R, Hobbins JC (1980) Assessment of fetal kidney size in normal gestation by comparison of ratio of kidney circumference to abdominal circumference. Am J Obstet Gynecol 136:249PubMedGoogle Scholar
  128. Hansmann M (1981 a) Nachweis und Ausschluß fetaler Entwicklungsstörungen mittels Ultraschallscreening und gezielter Untersuchung — ein Mehrstufenkonzept. Ultraschall 2: 206CrossRefGoogle Scholar
  129. Hansmann M (1981 b) Ultraschallscreening in der Schwangerschaft — Vorsicht vor übertriebenen Forderungen. Geburtshilfe Frauenheilkd 41: 725PubMedCrossRefGoogle Scholar
  130. Hansmann M (1984) Möglichkeiten und Grenzen sono-graphischer Diagnostik bei fetalen Erkrankungen und Mißbildungen. In: INA 47: Kowalewski S (Hrsg) 6. Symp. Pädiatr. Intensivmedizin. Thieme, Stuttgart New YorkGoogle Scholar
  131. Hansmann M, Gembruch U (1984) Gezielte sonographische Ausschlußdiagnostik fetaler Fehlbildungen in Ri-sikogruppen. Gynäkologe 17:19PubMedGoogle Scholar
  132. Hansmann M, Niesen M, Födisch HJ (1979) Pränatale Ultraschalldiagnose des Potter-Syndroms. Gynäkologe 12: 69Google Scholar
  133. Hobbins JC, Grannum PAT, Berkowitz RL, Silverman R, Mahoney MJ (1979) Ultrasound in the diagnosis of congenital anomalies. Am J Obstet Gynecol 134: 331PubMedGoogle Scholar
  134. Hobbins JC, Bracken MB, Mahoney MJ (1982a) Diagnosis of fetal skeletal dysplasias with ultrasound. Am J Obstet Gynecol 142:306PubMedGoogle Scholar
  135. Hobbins JC, Venus I, Tortora M, Mayden K, Mahoney MJ (1982b) Stage II ultrasound examination for the diagnosis of fetal abnormalities with an elevated amniotic fluid alpha-fetoprotein concentration. Am J Obstet Gynecol 142:1026PubMedGoogle Scholar
  136. Jassani MN, Gauderer MWL, Fanaroff AA, Fletcher B, Merkatz IR (1982) A perinatal approach to the diagnosis and management of gastrointestinal malformations. Obstet Gynecol 59: 33PubMedGoogle Scholar
  137. Johnson VP, Petersen LP, Hozwarth DR, Messner FD (1982) Midtrimester prenatal diagnosis of short-limb dwarfism (Saldino-Noonan-syndrome). Birth Defects 18:133PubMedGoogle Scholar
  138. Keith JD, Rowe RD, Vlad P (1978) Heart disease in infancy and childhood. Macmillan, New YorkGoogle Scholar
  139. Kirk EP, Wah RM (1983) Obstetric management of the fetus with omphalocele or gastroschisis: A review and report of one hundred twelve cases. Am J Obstet Gynecol 146:512PubMedGoogle Scholar
  140. Kleinebrecht J (1982) Arzneimittel in der Schwangerschaft. Deutscher Apotheker Verlag. StuttgartGoogle Scholar
  141. Knöpfle G, Födisch HJ, Hansmann M (1982) Das Potter-Syndrom. Prä- und postnatale Diagnostik. Verh Dtsch Ges Pathol 66: 278PubMedGoogle Scholar
  142. Knörr K (1983) Schwangerenvorsorge: Prävention für Mutter und Kind. Urban & Schwarzenberg, München Wien BaltimoreGoogle Scholar
  143. Kowalewski S (1984) Pränatale Diagnostik und symptomatische Therapie aus neonatologischer Sicht. Gynäkologe 17: 56–61PubMedGoogle Scholar
  144. Kucera J (1971) Rate and type of congenital anomalies among offspring of diabetic women. J Reprod Med 7:61Google Scholar
  145. Lehman RM (1981) Dandy-Walker syndrome in consecutive siblings: Femilial hindbrain malformation. Neurosurgery 8: 717PubMedCrossRefGoogle Scholar
  146. Leonard CO (1981) Serum AFP screening for neural tube defects. Clin Obstet Gynecol 24:1121PubMedCrossRefGoogle Scholar
  147. Malins JM (1979) Congenital malformations and fetal mortality in diabetic prognancy. J R Soc. Med 71: 205Google Scholar
  148. Mills JL, Baker L, Goldman AS (1979) Malformations in infants of diabetic mothers occur before the seventh gestational week. Implications for treatment. Diabetes 28: 292Google Scholar
  149. Nocke W (1978) Sind weibliche Sexualsteroide teratogen? Rückblick — Zwischenbilanz — Konsequenzen. Gynäkologe 11:119Google Scholar
  150. Nora JJ, Nora AH (1978) The evolution of specific genetic and environmental counseling in congenital heart diseases. Circulation 57: 205PubMedCrossRefGoogle Scholar
  151. Pagon RA, Smith DW, Shepard TH (1979) Urethral obstruction malformation complex: A cause of abdominal muscle deficiency and the “ prune belly”. J Pediatr 94:900PubMedCrossRefGoogle Scholar
  152. Pedersen JF, Molsted-Pedersen L (1981) Early fetal growth delay detected by ultrasound marks increased risk of congenital malformation in diabetic pregnancy. Br Med J 283: 269CrossRefGoogle Scholar
  153. Plotz EJ, Lang N, Hansmann M, Hinkers HJ, Garstka G, Niesen M, Bellmann O (1978) Diabetes mellitus und Schwangerschaft. Gynäkologe 11:67Google Scholar
  154. Queenan JT, O’Brien GD, Campbell S (1980) Ultrasound measurement of fetal limb bones. Am J Obstet Gynecol 138: 297PubMedGoogle Scholar
  155. Ramzin MS (1982) Teratogene Wirkung von Medikamenten. Gynäkologe 15:136PubMedGoogle Scholar
  156. Rehder H (1982) Fetalpathologie im Rahmen pränataler Diagnostik. Verh Dtsch Ges Pathol 66: 58PubMedGoogle Scholar
  157. Report of U.K. Collaborative Study (1977) On alphafetoprotein in relation to neural-tube defects. Maternal serum-alpha-fetoprotein measurement in antenatal screening for anencephaly and spina bifida in early pregnancy. Lancet I:1323Google Scholar
  158. Report of the Collaborative Acetylcholinesterase Study (1981) Amniotic fluid acetylcholinesterase electrophoresis as a secondary test in the diagnosis of anencephaly and open spina bifida in early pregnancy. Lancet II:321Google Scholar
  159. Robertson RD, Sarti DA, Brown WJ, Crandall BF (1981) Congenital hydrocephalus in two pregnancies following the birth of a child with neural tube defect: aetiology and management. J Med Genet 18:105PubMedCrossRefGoogle Scholar
  160. Schlensker KH (1981) Die sonographische Darstellung der fetalen Extremitäten im mittleren Trimenon. Geburtshilfe Frauenheilkd 41: 366PubMedCrossRefGoogle Scholar
  161. Second report of the U.K. Collaborative Study (1979) On alpha-fetoprotein in relation to neural-tube defects. Amniotic fluid alpha-fetoprotein measurement in antenatal diagnosis of anencephaly and open spina bifida in early pregnancy. Lancet II: 651Google Scholar
  162. Shannon MW, Nadler HL (1968) X-linked hydrocephalus. J Med Genet 5: 326PubMedCrossRefGoogle Scholar
  163. Sillence DO, Senn A, Danks DM (1979) Genetic heterogenity in osteogenesis imnerfecta. J Med Genet 16:101PubMedCrossRefGoogle Scholar
  164. Taybi H (1983) Radiology of syndromes and metabolic disorders. Year Book Medical Publishers, Chicago LondonGoogle Scholar
  165. Warkany J (1971) Congenital malformations. Year Book Medical Publishers, Chicago LondonGoogle Scholar
  166. Weiß H, Zerres K, Hansmann M (1981) Pränatale Diagnose zystischer Nierenveränderungen mit Hilfe der Ultraschalltechnik. Ultraschall 2: 205CrossRefGoogle Scholar
  167. Weitzel H (1983) Alpha-Fetoprotein in der Geburtshilfe. Gynäkologe 16:148PubMedGoogle Scholar
  168. Zerres K, Födisch HJ (1982) Kongenitale Zystennieren. Probleme der Klassifikation aus morphologischer und humangenetischer Sicht. Verh Dtsch Ges Pathol 66: 285PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • Manfred Hansmann
    • 1
  • Bernhard-Joachim Hackelöer
    • 2
  • Alfons Staudach
    • 3
  1. 1.Abteilung für Pränatale Diagnostik und TherapieUniversitäts-FrauenklinikBonn 1Deutschland
  2. 2.Medizinisches Zentrum für Frauenheilkunde und GeburtshilfePhilipps-UniversitätMarburgDeutschland
  3. 3.LandesfrauenklinikLandeskrankenhaus SalzburgSalzburgÖsterreich

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