Sensitive Adenylate Cyclase Bioassay for Parathyroid Hormone

  • H. Scharfenstein

Abstract

A large number of substances such as dopamine, secretin, prostaglandin E2, βadrenergic catechecholamines, and parathyroid hormone (PTH) activate adenylate cyclase by interacting with appropriate endogenous ligands on the cell surface. These interactions ultimately result in stimulation of adenylate cyclase activity and thus in an increase of cAMP production. Prostaglandin F2 and α2-adrenergic substances, however, lower the cAMP level by inhibiting adenylate cyclase.

Keywords

Sucrose Urea Dopamine Adenoma Fractionation 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • H. Scharfenstein

There are no affiliations available

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