Sensitive Adenylate Cyclase Bioassay for Parathyroid Hormone

  • H. Scharfenstein


A large number of substances such as dopamine, secretin, prostaglandin E2, βadrenergic catechecholamines, and parathyroid hormone (PTH) activate adenylate cyclase by interacting with appropriate endogenous ligands on the cell surface. These interactions ultimately result in stimulation of adenylate cyclase activity and thus in an increase of cAMP production. Prostaglandin F2 and α2-adrenergic substances, however, lower the cAMP level by inhibiting adenylate cyclase.


Parathyroid Hormone Adenylate Cyclase Renal Cortex Ethylene Glycol Tetraacetic Acid Ethylene Glycol Tetraacetic Acid 
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© Springer-Verlag Berlin Heidelberg 1990

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  • H. Scharfenstein

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