Dermatology pp 1124-1126 | Cite as

Paraneoplastic Syndromes

  • Otto Braun-Falco
  • Gerd Plewig
  • Helmut H. Wolff
  • Richard K. Winkelmann


The term paraneoplastic syndromes refers to skin lesions that often occur concomitantly with malignant diseases of internal organs and are therefore of considerable diagnostic importance. They are not, however, directly associated with the malignant tumor, i.e., they do not represent skin metastases. The exact pathological mechanism of paraneoplastic skin lesions varies. They may be an expression of an allergic skin reaction to a tumor antigen or the result of mediators, peptides, or hormones produced by tumors. Malignant tumors and the skin lesions may either develop concurrently or follow each other after a relatively short interval. The malignant tumor and the skin lesions then both persist. It is not uncommon for a particular type of malignant tumor to be associated with specific skin lesions, e.g., adenocarcinoma with acanthosis nigricans or with Gammel’s syndrome. The skin lesions may be relatively common or very rare, e.g., acrokeratosis of Bazex-Dupré. In genetically conditioned malignant tumors (e.g., Gardner’s syndrome), the skin lesions do not always develop concurrently and may not take a parallel course.


Herpes Zoster Pyoderma Gangrenosum Bullous Pemphigoid Epidermolysis Bullosa Paraneoplastic Syndrome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Pityriasis Rotunda

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Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • Otto Braun-Falco
    • 1
  • Gerd Plewig
    • 2
  • Helmut H. Wolff
    • 3
  • Richard K. Winkelmann
    • 4
  1. 1.Dermatologische Klinik und PoliklinikLudwig-Maximilians-Universität MünchenMünchen 2Federal Republic of Germany
  2. 2.Hautklinik der Heinrich-Heine-UniversitätDüsseldorfFederal Republic of Germany
  3. 3.Klinik für Dermatologie und VenerologieMedizinischen Universität zu LübeckLübeck 1Federal Republic of Germany
  4. 4.Dermatology — Dermatopathology, Mayo ClinicMayo Medical SchoolRochesterUSA

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