Dermatology pp 923-925 | Cite as

Disorders of Purine Metabolism

  • Otto Braun-Falco
  • Gerd Plewig
  • Helmut H. Wolff
  • Richard K. Winkelmann


Gout is a heterogeneous group of disorders of purine metabolism which leads to hyperuricemia and arthritis as well as gout nodules (tophi) from deposition of urate crystals in and around the joints and in the skin. The hyperuricemia in primary gout is related to overproduction or reduced renal excretion of uric acid, while in secondary gout it is due to increased purine biosynthesis and the consequent overproduction of uric acid. The latter is known as a complication in chronic leukemia and other myeloproliferative diseases, in polycythemia vera and after cytostatic treatment, and in extensive psoriasis vulgaris (elevated nucleolysis with secondary hyperuricemia).


Podagra arthritis urica Automutilation syndrome 


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Bibliography: Disorders of Purine Metabolism


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Lesch-Nyhan Syndrome

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Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • Otto Braun-Falco
    • 1
  • Gerd Plewig
    • 2
  • Helmut H. Wolff
    • 3
  • Richard K. Winkelmann
    • 4
  1. 1.Dermatologische Klinik und PoliklinikLudwig-Maximilians-Universität MünchenMünchen 2Federal Republic of Germany
  2. 2.Hautklinik der Heinrich-Heine-UniversitätDüsseldorfFederal Republic of Germany
  3. 3.Klinik für Dermatologie und VenerologieMedizinischen Universität zu LübeckLübeck 1Federal Republic of Germany
  4. 4.Dermatology — Dermatopathology, Mayo ClinicMayo Medical SchoolRochesterUSA

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