Dermatology pp 511-532 | Cite as


  • Otto Braun-Falco
  • Gerd Plewig
  • Helmut H. Wolff
  • Richard K. Winkelmann


The epidermis is the outermost skin layer that protects man from his environment. Its own uppermost layer is the stratum corneum. The cornifying squamous epithelium is an ectodermal structure consisting of the basal layer, spinous layer, and granular layer, which are made up of keratinocytes, and the stratum corneum, which contains corneocytes Besides keratinocytes, other cell types occur in the skin and account for approximately 10% of the total cell population. They include the melanin-forming melanocytes which occur in the dermoepidermal transitional zone and between basal cells, Langerhans cells which belong to the monocyte-macrophage system in the lower strata of the epidermis, and Merkel’s cells, which are specially differentiated keratinocytes, or Schwann cells originating from the neural crest that may act with nerve axons as mechanoreceptors.


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Bibliography: Keratoses


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Palmar and Plantar Keratoses

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Follicular Keratoses

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Circumscribed Keratoses Not Restricted to the Follicles

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Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • Otto Braun-Falco
    • 1
  • Gerd Plewig
    • 2
  • Helmut H. Wolff
    • 3
  • Richard K. Winkelmann
    • 4
  1. 1.Dermatologische Klinik und PoliklinikLudwig-Maximilians-Universität MünchenMünchen 2Federal Republic of Germany
  2. 2.Hautklinik der Heinrich-Heine-UniversitätDüsseldorfFederal Republic of Germany
  3. 3.Klinik für Dermatologie und VenerologieMedizinischen Universität zu LübeckLübeck 1Federal Republic of Germany
  4. 4.Dermatology — Dermatopathology, Mayo ClinicMayo Medical SchoolRochesterUSA

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