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Some Variations in Childhood Cancers Throughout the World

  • J. N. P. Davies
Part of the Recent Results in Cancer Research / Fortschritte der Krebsforschung / Progrès dans les recherches sur le cancer book series (RECENTCANCER, volume 13)

Abstract

Despite the high proportion which children form of the total population of tropical and sub-tropical countries paediatrics was till recent years a very neglected field and when in 1958 BRAS [1] surveyed what was known of childhood neoplasia in such countries it was the most dark and dismal part of this neglected field. Very little information was available; this was not surprising because even in medically advanced countries the subject had attracted little attention till, with the decline in other lethal diseases in childhood, it became a major cause of death. In many countries there has been little decline in the other fatal diseases of childhood. If children with cancer were brought to medical attention they often came late, no effective treatment was available and usually the only purpose of a biopsy was to exclude some more readily treatable condition. If the situation has changed somewhat since 1958 it is because there has been a heightened interest in the geography and epidemiology of cancer [2, 3] and its influencing factors and because it has become evident that, as with adults so with children, there are striking variations in the site and type frequencies of cancer from country to country that almost certainly reflect the effect of environmental influences. Particularly in Africa [4, 5, 6, 7] have cancer surveys been set up in a concerted effort to obtain cancer incidence rates in selected areas and though chiefly concerned with adult cancers these have provided much information about cancer in childhood there and elsewhere [8]. At the same time much interest has been aroused by the curious features of solid lymphomatous tumours in children in Africa [9, 10]. Particular attention will therefore be devoted in this chapter to African experiences.

Keywords

Malignant Lymphoma Childhood Cancer Childhood Leukemia African Child Granulosa Cell Tumour 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Bras, G.: Malignant neoplasms. Chapter 23 in Trowell, H. C., and D. B. Jelliffe (Eds.): Diseases of children in the subtropics and tropics. London: Edward Arnold 1958.Google Scholar
  2. 2.
    Bibliography on the epidemiology of Cancer 1946–1960. World Health Organisation, Geneva, 1963, 168 pp.Google Scholar
  3. 3.
    Bibliography on cancer in Africa. South African Cancer Bulletin, 1963. Vol. 7, No. 4 Supplement, 106 pp.Google Scholar
  4. 4.
    Higginson, J., and A. G. Oettle: Cancer incidence in the Bantu and “Cape Colored” races of South Africa. Report of a cancer survey in the Transvaal (1953–55). J. Nat. Cancer Inst. 24, 589–671 (1960).PubMedGoogle Scholar
  5. 5.
    Davies, J. N. P., J. Knowelden, and B. A. Wilson: Incidence rates of cancer in Kyadondo County, Uganda 1954–1960. J. Nat. Cancer Inst. 35, 789–821 (1965).PubMedGoogle Scholar
  6. 6.
    Prates, M. D., and F. O. Torres: A cancer survey in Lourenço Marques. Portugese East Africa. J. Nat. Cancer Inst. 35, 729–757 (1965).PubMedGoogle Scholar
  7. 7.
    Edington, G. M., and C. M. Maclean: A cancer rate survey in Ibadan, Western Nigeria 1960–1963. Brit. J. Cancer 19, 471–481 (1965).CrossRefPubMedCentralGoogle Scholar
  8. 8.
    Bras, G., D. C. Walter, and A. Ashmead-Dyer: The incidence of malignant neoplasms in Jamaica. Brit. J. Cancer 19, 681–794 (1965).PubMedCrossRefPubMedCentralGoogle Scholar
  9. 9.
    O’conor, G. T., and J. N. P. Davies: Malignant tumours in African children, with special reference to malignant lymphoma. J. Pediat. 56, 526–535 (1960).PubMedCrossRefGoogle Scholar
  10. 10.
    Roulet, F. C. (Ed.): Symposium on lymphoreticular tumours in Africa. Basel: Karger 1964.Google Scholar
  11. 11.
    Hutt, M. S. R., and D. P. Burkitt: Geographical distribution of cancer in East Africa. A new clinicopathological approach. Brit. med. J. 2, 719–722 (1965).Google Scholar
  12. 12.
    Linsell, C. A., and R. Martyn: The Kenya Cancer Registry. East Afr. med. J. 39, 642–648 (1962).Google Scholar
  13. 13.
    Trowell, H. C., and D. B. Jelliffe (Eds.): Diseases of children in the subtropics and tropics. London: Edward Arnold 1958.Google Scholar
  14. 14.
    Trowell, H. C., and D. B. Jelliffe (Eds.): Non-infective disease in Africa. London: Edward Arnold 1960.Google Scholar
  15. 15.
    Geber, M., and R. F. A. Dean: The state of development of new born African children. Lancet 1, 1216–1219 (1957).CrossRefGoogle Scholar
  16. 16.
    Simfkiss, M., and A. Lowe: Congenital abnormalities in the African newborn. Arch. Dis. Child. 36, 404–409 (1961).CrossRefGoogle Scholar
  17. 17.
    Dodge, O. G., and B. Mckinney: Causes of perinatal death in Uganda Africans with special reference to congenital malformations. J. Pediat. 65, 267–269 (1964).PubMedCrossRefGoogle Scholar
  18. 18.
    Davies, J. N. P.: Children’s diseases at Mulago Hospitals 1950–51. An analysis of the causes of admission. East Afr. med. J. 32, 283–290 (1955).Google Scholar
  19. 19.
    Cancer registration in Norway. The incidence of cancer in Norway 1953–1958. Oslo: Norwegian Cancer Society 1961.Google Scholar
  20. 20.
    Dorn, H. F., and S. T. Cutler: Morbidity from cancer in the United States. Public Health Monograph No. 56, 207 (1959).Google Scholar
  21. 21.
    Steward, J. K.: The management of tumours in children. Practitioner 196, 104–109 (1966).Google Scholar
  22. 22.
    Bjelke, E.: Cancer registry of Norway. Personal communication 1961.Google Scholar
  23. 23.
    Cohen, D., and G. W. G. Lee: An investigation of malignant disease in childhood. Publication No. 5, New South Wales State Cancer Council, Sydney, 1961, 54 pp.Google Scholar
  24. 24.
    The tumour registry. Charity Hospital of Louisiana. Personal communication from Miss Brent Robertson, Director, by courtesy of Dr. E. T. Krementz and the board of the tumor registry.Google Scholar
  25. 25.
    Department of Pathology, St. Casa de Misericordia. Sao Paulo, Brasil. Personal communication from Dr. C. MARIGO.Google Scholar
  26. 26.
    Aguirre, A., y M. S. Sosa: Tumours malignos en la infancia. Rev. Inst. nac. Cancer (Mexico) 1, 93–109 (1955).Google Scholar
  27. 27.
    Muir, C. S.: Cancer in Singapore children. Cancer 14, 534–538 (1961). 3 R. R. Cancer Research, Vol. 13Google Scholar
  28. 28.
    Stransky, E., and D. L. Africa: Malignancies in children. Philippine J. Cancer 4, 138–143 (1962).Google Scholar
  29. 29.
    Capetown, Children’s Tumour Registry. Personal communication from Dr. M. B. Bennet.Google Scholar
  30. 30.
    EL. Gazayerli, M., and H. A. Khalil: Malignant neoplasms in children. Analysis of 91 pathological cases. Alexandria med. J. 7, 410–418 (1961).Google Scholar
  31. 31.
    Thijs, A.: Considerations sur les tumeurs malignes des Indigenes du Congo Belge et du Ruanda-Urundi. A propos de 2356 Cas. Ann. Soc. Belge Med. Trop. 37, 483–492 (1957).PubMedGoogle Scholar
  32. 32.
    Edington, G. M., and C. M. U. Maclean: Incidence of the Burkitt tumour in Ibadan, Western Nigeria. Brit. med. J. 1, 264–266 (1964).Google Scholar
  33. 33.
    Davies, J. N. P.: Leukemia in children in tropical Africa. Lancet 2, 65–67 (1965).CrossRefGoogle Scholar
  34. 34.
    Ederer, F., R. W. Miller, and J. Scotto: U. S. childhood cancer mortality patterns, 1950–1959. Etiologic implications. J. Amer. med. Ass. 192, 593–596 (1965).CrossRefGoogle Scholar
  35. 35.
    Davies, J. N. P.: Lymphomas and leukemias in Uganda Africans. In Roulet, F. C.: Op. Cit. Ref. 10, p. 67–69.Google Scholar
  36. 36.
    Dalldorf, G.: Lymphomas of African children with different forms or environmental influences. J. Amer. med. Ass. 181, 1026–1928 (1962).CrossRefGoogle Scholar
  37. 37.
    Dalldorf, G., C. A. Linsell, F. E. Barnhart, and R. Martyn: An epidemiologic approach to the lymphomas of African children and Burkitt’s sarcoma of the jaws. Perspect. Biol. Med. 7, 435–449 (1964).PubMedGoogle Scholar
  38. 38.
    Davies, J. N. P., and R. Owor: Chloromatous tumours in African children in Uganda. Brit. med. J. 2, 405–407 (19165).Google Scholar
  39. 39.
    Hayhoe, F. G. J.: Leukemia. Boston: Little Brown 1960.Google Scholar
  40. 40.
    Davies, A. G. M., and J. N. P. Davies: Tumours of the jaw in Uganda Africans. Acta Un. Canc. 16, 1320–1324 (19[60).Google Scholar
  41. 41.
    Wright, D. H.: Cytology and histochemistry of the malignant lymphomas seen in Uganda. In RouLET, F. C.: Op. Cit. Ref. 10, p. 291–303.Google Scholar
  42. 42.
    Burkitt, D. P.: Sarcoma involving jaws in African children. Brit. J. Surg. 46, 218–223, (1958).PubMedCrossRefGoogle Scholar
  43. 43.
    Wright, D. H.: Involvement of the jaws in Burkitt’s tumour (letter). Lancet 1963 II, 151.CrossRefGoogle Scholar
  44. 44.
    Lehner, T.: The jaws and teeth in Burkitt’s tumour (African lymphoma). J. Path. Bact. 88, 581–585 (1964).PubMedCrossRefGoogle Scholar
  45. 45.
    O’conor, G. T.: Malignant lymphoma in African children, ii. A pathological entity. Cancer 14, 270–283 (1961).PubMedCrossRefGoogle Scholar
  46. 46.
    Stansfield, D.: Haematological findings in African children in Uganda with malignant lymphoma. Brit. J. Cancer 15, 41–44 (1961).PubMedCrossRefPubMedCentralGoogle Scholar
  47. 47.
    Clift, A. A., D. H. Wright, and P. Clifford: Leukemia in Burkitt’s lymphoma. Blood 22, 243–251 (1963).PubMedGoogle Scholar
  48. 48.
    Wright, D. H.: Cytology and histochemistry of the Burkitt lymphoma. Brit. J. Cancer 17, 50–55 (1963).PubMedCrossRefPubMedCentralGoogle Scholar
  49. 49.
    Wright, D. H.: Burkitt’s tumour. A post-mortem study of 50 cases. Brit. J. Surg. 51, 245–251 (1964).PubMedCrossRefGoogle Scholar
  50. 50.
    Wright, D. H.: Malignant lymphoma in Uganda. M. D. Thesis, University of Bristol, England, 1964.Google Scholar
  51. 51.
    Gall, E. A.: Ecologic factors in neoplasms. J. Pediat. 56, 584 (1960).CrossRefGoogle Scholar
  52. 52.
    Burkitt, D. P., and G. T. O’conor: Malignant lymphoma in African children. I. A clinical syndrome. Cancer 14, 258–269 (1961).PubMedCrossRefGoogle Scholar
  53. 53.
    Burkitt, D. P., and G. T. O’conor: A tumour syndrome affecting children in tropical Africa. Postgrad. med. J. 38, 71–79 (1962).CrossRefGoogle Scholar
  54. 54.
    Cockshott, W. P.: Radiology of Burkitt’s tumour in young Nigerians. In ROULET, F. C.: Op. Cit. Ref. 10, p. 150–162.Google Scholar
  55. 55.
    Burkitt, D. P.: Observations on the geography of malignant lymphoma. E. Afr. med. J. 38, 511–514 (1961).Google Scholar
  56. 56.
    Burkitt, D. P.: A children’s cancer dependent on climatic factors. Nature 194, 232–234 (1962).PubMedCrossRefGoogle Scholar
  57. 57.
    Burkitt, D. P.: Determining the climatic limits of a children’s cancer common in Africa. Brit. med. J. 2, 1019–1023 (1962).CrossRefGoogle Scholar
  58. 58.
    Burkitt, D. P.: A “tumour safari” in East and Central Africa. Brit. J. Cancer 16, 279–386 (1962).Google Scholar
  59. 59.
    Burkitt, D. P., and D. H. Wright: Geographical and tribal distribution of the African lymphoma in Uganda. Brit. med. J. 1, 569–573 (1966).Google Scholar
  60. 60.
    Haddow, A. T.: An improved map for the study of Burkitt’s lymphoma syndrome in africa. E. Afr. med. J. 40, 429–432 (1963).Google Scholar
  61. 61.
    Gluckman, J.: Multifocal lymphoma in South Africa. S. Afr. Cancer Bull. 7, 7–12 (1963).Google Scholar
  62. 62.
    Goma, L. K. H.: The environmental background to cases of Burkitt’s lymphoma in Uganda. E. Afr. med. J. 42, 62–66 (1965).Google Scholar
  63. 63.
    Burkitt, D. P., and J. N. P. Davies: Lymphoma syndrome in Uganda and tropical Africa. Med. Press 245, 367–369 (1961).Google Scholar
  64. 64.
    Pulvertaft, R. J. V.: A study of malignant tumours in Nigeria by short-term tissue culture. J. Clin. Path. 18, 261–273 (1965).PubMedCrossRefPubMedCentralGoogle Scholar
  65. 65.
    Epstein, M. A., G. Henle, B. G. Achong, and Y. M. Barr: Morphological and biological studies on a virus in cultured lymphoblasts from Burkitt’s lymphoma. J. exp. Med. 121, 761–770 (1965).PubMedCrossRefPubMedCentralGoogle Scholar
  66. 66.
    Epstein, M. A., G. Henle, B. G. Achong, and Y. M. Barr, and Y. M. Barr: Cultivation in vitro of human lymphoblasts from Burkitt’s malignant lymphoma. Lancet 1, 252–253 (1964).PubMedCrossRefGoogle Scholar
  67. 67.
    Epstein, M. A., G. Henle, B. G. Achong, and Y. M. Barr, G. Achong, and Y. M. Barr: Virus particles in cultured lymphoblasts from Burkitt’s lymphoma. Lancet 2, 702–703 (1964).CrossRefGoogle Scholar
  68. 68.
    Stewart, S. E.: Biological activity of the virus of the Burkitt tumour SL cell lines. Trans. N. Y. Acad. Sci., Series II 28, 291–303 (1965).CrossRefGoogle Scholar
  69. 69.
    Dalldorp, G., and F. Bergamini: Unidentified filterable agents isolated from African children with malignant lymphoma. Proc. nat. Acad. Sci. (Wash.) 51, 263–264 (1964).CrossRefGoogle Scholar
  70. 70.
    Dalldorp, G., and F. Bergamini, and P. Frost: Further observations on the lymphoma of African children. Proc. nat. Acad. Sci. (Wash.) 55, 297–302 (1966).CrossRefGoogle Scholar
  71. 71.
    Bell, T. M., A. Massie, M. G. R. Ross, and M. C. Williams: Isolation of a Reo virus from a case of Burkitt’s lymphoma. Brit. med. J. 1, 1212–1213 (1964).Google Scholar
  72. 72.
    East African Virus Research Institute Report, July 1963-December 1964. Entebbe, Uganda, 1965.Google Scholar
  73. 73.
    Stanley, N. F.: Hypothesis. The aetiology and pathogenesis of Burkitt’s African lymphoma. Lancet 1, 961–962 (1966).PubMedCrossRefGoogle Scholar
  74. 74.
    Ten Seldam, R. J., R. Cooke, and L. Atkinson: Childhood lymphoma in the territories of Papua and New Guinea. Cancer 19, 437–448 (1966).CrossRefGoogle Scholar
  75. 75.
    Schmamann, A., B. Gampel, and C. H. Luntz: The Burkitt lymphoma syndrome in Johannesburg. S. Afr. med. J. 39, 741–746 (1965).Google Scholar
  76. 76.
    Wright, D. H.: Department of Pathology, Makerere University College Medical School, Kampala, Uganda. Personal communication.Google Scholar
  77. 77.
    O’conor, G. T., H. Rappaport, and E. B. Smith: Childhood lymphoma resembling Burkitt’s tumour in the United States. Cancer 18, 411–417 (1965).PubMedCrossRefGoogle Scholar
  78. 78.
    Dorfman, R. F.: Childhood lymphosarcoma in St. Louis, Missouri, clinically and histologically resembling Burkitt’s tumour. Cancer 18, 418–430 (1965).PubMedCrossRefGoogle Scholar
  79. 79.
    Louisi, A., A. De P. Bertelli, J. C. Machado and J. P. Ache Y De Freitas: Linfoma africano en criancas brasileiras. Rev. Brasil. Cirerg. 49, 280–295 (1965).Google Scholar
  80. 80.
    Beltran, G., A. Baez, and P. Correa: Burkitt’s lymphoma in Colombia. Amer. J. Med. 40, 211–216 (1966).PubMedCrossRefGoogle Scholar
  81. 81.
    Burkitt, D. P., M. S. R. Hutt, and D. H. Wright: The African lymphoma; preliminary observations on response to therapy. Cancer 18, 399–410 (1965).PubMedCrossRefGoogle Scholar
  82. 82.
    Conference on the chemotherapy of lymphomas. Kampala, January 1966. Copenhagen: Munksgaard (in press).Google Scholar
  83. 83.
    Burkitt, D. P.: Leukemia Research Fund Lecture, 1966. See Lancet 1, 803 (1966).Google Scholar
  84. 84.
    Rosenberg, S. A., H. D. Diamond, H. W. Dorgeon, B. Taslowitz, and L. F. Carver: Lymphosarcoma. A review of 1269 cases. Medicine (Baltimore) 40, 31–84 (1961).CrossRefGoogle Scholar
  85. 85.
    O’conor, G. T.: Significant aspects of childhood lymphoma in Africa. Cancer Res. 23, 1514–1518 (1963).PubMedGoogle Scholar
  86. 86.
    Lothe, F.: Kaposi’s sarcoma in Uganda Africans. Oslo: Universitatsforlaget 1963.Google Scholar
  87. 87.
    Ackerman, L. V., and J. F. MURRAY: Symposium on Kaposi’s sarcoma. Basel: Karger 1963.Google Scholar
  88. 88.
    Palmer, P. E. S.: The radiological changes of Kaposi’s sarcoma. In Acxerman, L. V., and J. Murray: Op. Cit. Ref. 87, p. 87–99.Google Scholar
  89. 89.
    Davies, A. G. M.: Bone changes in Kaposi’s sarcoma. An analysis of 15 cases occurring in Bantu Africans. J. Fac. Radiol. 8, 32–40 (1956).CrossRefGoogle Scholar
  90. 90.
    Davies, J. N. P., and F. Lothe: Kaposi’s sarcoma in African children. In Ackerman, L. V., and J. F. MURRAY: Op. Cit. Ref. 87, p. 81–86.Google Scholar
  91. 91.
    Durz, W., and A. P. Stout: Kaposi’s sarcoma in children. Cancer 13, 684–694 (1960).CrossRefGoogle Scholar
  92. 92.
    Mclaren, D. S.: Kaposi’s sarcoma of the eyelids of an African child. Arch. Ophthalmol. 63, 859–861 (1960).CrossRefGoogle Scholar
  93. 93.
    Tasque, P.: Journiac Dzeitheim. Maladie de kaposi chez un enfant camerounais de 3 ans 1/2 â aspect de macro-poly-adenopathies généralisée d’evolution mortelle en 14 mois. Semaine Hôp. (Paris) 31, 4077–4078 (1958).Google Scholar
  94. 94.
    Jelliffe, D. B., J. Coox, and J. N. P. Davies: Disseminated glandular Kaposi sarcoma in a Uganda child. J. Pediat. 61, 452–455 (1962).PubMedCrossRefGoogle Scholar
  95. 95.
    Oettlé, A. G.: Geographical and racial differences in the frequency of Kaposi’s sarcoma as evidence of environmental or genetic causes. In Ackerman, L. V., and J. F. Murray: Op. Cit. Ref. 87, p. 17–50.Google Scholar
  96. 96.
    Bodian, M., and B. G. Ockenden: Aspects of cancer in childhood. In GAIRDNER, D.: Recent advances in pediatrics. Boston: Little Brown 1965, pp. 266–293.Google Scholar
  97. 97.
    Besuschio, S. C.: Problèmes posés par la pathologie néoplastique enfantile en argentine. Ann. Chir. Infant. (Paris) 4, 313–320 (1963).Google Scholar
  98. 98.
    Marsden, A. T. H.: The cancers of infants and young children in Malaya. Med. J. Malaya 14, 158–161 (1960).PubMedGoogle Scholar
  99. 99.
    Allen, N. C., and E. J. A. Watson-Williams: Study of leukemia among Nigerians in Ibadan. Proc. 9th Congr. Europ. Soc. Haemat. Lisbon. Basel: Karger 1963, p. 906 to 915.Google Scholar
  100. 100.
    Cooray, C. H., and R. Perera: The pattern of neoplastic disease in Ceylonese infants and children. Brit. J. Cancer 20, 1–11 (1966).CrossRefPubMedCentralGoogle Scholar
  101. 101.
    Miller, R. W., J. F. Fraumeni, and M. D. Manning: Association of Wilms’ tumours with anidria, hemihypertrophy and other congenital malformations. New. Engl. Med. J. 270, 922–927 (1964).CrossRefGoogle Scholar
  102. 102.
    Steward, J. K.: Malignant disease. In Holzel, A., and J. P. M. Tizard (Eds.): Modern trends in pediatrics (second series). London: Butterworth 1958.Google Scholar
  103. 103.
    Dodge, O. G.: Bone tumours in Uganda Africans. Brit. J. Cancer 18, 627–633 (1964).PubMedCrossRefPubMedCentralGoogle Scholar
  104. 104.
    Willis, R. A.: The pathology of the tumours of children. Edinburgh: Oliver and Boyd 1962.Google Scholar
  105. 105.
    Jay, B.: Naeviand melanomata of the conjunctiva. Brit. J. Ophthalmol. 49, 1, 69–204 (1965).Google Scholar
  106. 106.
    Davies, J. N. P.: Sex hormone upset in Africans. Brit. med. J. 2, 676–679 (1949).CrossRefGoogle Scholar
  107. 107.
    Clifford, P.: Carcinoma of the nasopharynx in Kenya. E. Afr. med. J. 42, 373–396 (1965).Google Scholar
  108. 108.
    Bersohn, I., and P. J. Oelefsee: A comparison of urinary oestrogen levels in normal male South African Bantu and European subjects. S. Afr. med. J. 31, 1172–1174 (1957).PubMedGoogle Scholar
  109. 109.
    Winship, T., and R. U. RosvoLL: Childhood thyroid carcinoma. Cancer 14, 734–743 (1961).PubMedCrossRefGoogle Scholar
  110. 110.
    Steward, J. K.: Need for a “team approach” to clinical and research problems of children’s tumours. Brit. med. J. 1, 767–770 (1966).PubMedCrossRefPubMedCentralGoogle Scholar
  111. 111.
    Oetrlé, A. G.: Cancer in Africa, especially in regions south of the Sahara. J. nat. Cancer Inst. 33, 383–439 (1964).Google Scholar

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  • J. N. P. Davies

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