Abstract
By definition carbonyl moieties display electrophilic character at the carbonyl carbon and nucleophilic character at the α-position. Through deprotonation aldehydes, ketones, esters, amides and nitriles form enolates which react with electrophiles to yield α-functionalized products. Examples of such electrophiles include aldehydes, ketones or esters themselves.
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© 2020 The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Fachmedien Wiesbaden GmbH, part of Springer Nature
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Lemmerer, M. (2020). Introduction. In: Chemoselective Nucleophilic α-Amination of Amides. BestMasters. Springer Spektrum, Wiesbaden. https://doi.org/10.1007/978-3-658-30020-3_1
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DOI: https://doi.org/10.1007/978-3-658-30020-3_1
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Publisher Name: Springer Spektrum, Wiesbaden
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Online ISBN: 978-3-658-30020-3
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