ODE Constrained Mixture Modeling for Multivariate Data Using Moment Equations

  • Carolin Loos
Part of the BestMasters book series (BEST)


The focus of this chapter is to assess, improve and extend ODE constrained mixture modeling (ODE-MM) (Hasenauer et al., 2014b), a method for studying dynamics and structures of subpopulations. In Section 3.1, we introduce the underlying method and formulate the problems that are subsequently addressed in the following sections. In Section 3.2, we apply ODE-MMs to novel single-cell snapshot data for NGF-induced Erk signaling.


Mixture Modeling Multivariate Data Moment Equation Mixture Distribution Multivariate Normal Distribution 
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Copyright information

© Springer Fachmedien Wiesbaden 2016

Authors and Affiliations

  1. 1.Helmholtz Zentrum MünchenInstitute of Computational BiologyMünchenGermany

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