Paper 2: Expression levels of the microRNA maturing microprocessor complex component DGCR8 and the RNA-induced silencing complex (RISC) components argonaute-1, argonaute-2, PACT, TARBP1 and TARBP2 in epithelial skin cancer
microRNAs (miRNAs) are thought to play an important role in the posttranscriptional gene regulation of up to 30% of all human genes . The updated version (V.17) of the miRNA database miRBase currently distinguishes 1424 different human miRNA sequences . miRNAs are capable of regulating gene expression both by promoting mRNA degradation and by inhibiting mRNA translation . The maturation of miRNAs occurs in the nucleus and the cytoplasm. The process begins in the nucleus, where the intranuclear enzyme Drosha, an RNase III endonuclease, cleaves pri-miRNAs (consisting of a hairpin stem, a terminal loop, and 5` and 3` single-stranded RNA extensions) to premiRNAs (60-70 nucleotide stem-loop structures).
KeywordsAdenosine Dermatol Keratosis
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