Paper 2: Expression levels of the microRNA maturing microprocessor complex component DGCR8 and the RNA-induced silencing complex (RISC) components argonaute-1, argonaute-2, PACT, TARBP1 and TARBP2 in epithelial skin cancer

  • Michael Sand


microRNAs (miRNAs) are thought to play an important role in the posttranscriptional gene regulation of up to 30% of all human genes [1]. The updated version (V.17) of the miRNA database miRBase currently distinguishes 1424 different human miRNA sequences [2]. miRNAs are capable of regulating gene expression both by promoting mRNA degradation and by inhibiting mRNA translation [3]. The maturation of miRNAs occurs in the nucleus and the cytoplasm. The process begins in the nucleus, where the intranuclear enzyme Drosha, an RNase III endonuclease, cleaves pri-miRNAs (consisting of a hairpin stem, a terminal loop, and 5` and 3` single-stranded RNA extensions) to premiRNAs (60-70 nucleotide stem-loop structures).


Basal Cell Carcinoma Actinic Keratose Healthy Subject Cervical Squamous Cell Carcinoma Cervical Squamous Cell Carcinoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Fachmedien Wiesbaden 2016

Authors and Affiliations

  • Michael Sand
    • 1
  1. 1.BochumGermany

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