Paper 9: microRNA in non-melanoma skin cancer
MicroRNAs (miRNAs) are 17- to 23-nucleotide (nt), short, non-coding RNA molecules that are capable of regulating gene expression at a posttranscriptional level. Encoded within both exons and introns, they play a pivotal role in a variety of physiologic cellular functions and diseases, including cancer. Approximately 30%–60% of all human genes are affected by miRNA regulation, and our understanding of their role as both tumor suppressors and oncogenes in a variety of different cancers is gradually evolving. In this mini-review, we summarize the current knowledge on the role of miRNAs in non-melanoma skin cancer (NMSC). All the differentially expressed miRNAs in NMSC have been compiled in table 12-1.
KeywordsBasal Cell Carcinoma Lung Squamous Cell Carcinoma Cutaneous Squamous Cell Carcinoma Nonmelanoma Skin Cancer Cervical Squamous Cell Carcinoma
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